Inhalable DNase I@Au hybrid nanoparticles for radiation sensitization and metastasis inhibition by elimination of neutrophil extracellular traps.

High-dose radiation therapy is a widely used clinical strategy to inhibit tumor growth. However, the rapid generation of excessive reactive oxygen species (ROS) triggers the formation of neutrophil extracellular traps (NETs), which capture free tumor cells in the bloodstream, promoting metastasis. In this study, we developed a hybrid nanoparticle composed of DNase I and gold (DNase I@Au) to enhance radiotherapy efficacy while mitigating metastasis by precisely eliminating NETs.

Exploiting Lattice Carbon-Induced Modulation Effect in Nickel towards Efficient Alkaline Hydrogen Oxidation.

Doping with non-metallic heteroatom is an effective approach to tailor the electronic structure of Ni for enhancing its alkaline hydrogen oxidation reaction (HOR) catalytic performance. However, the modulation of HOR activity of Ni by lattice carbon (LC) atoms has rarely been reported, especially to reveal the rule between the doping effect and activity caused by the content of LC atoms. Here, hydrogen is proposed as a scavenger for LC atoms in the pyrolytic reduction process to finely control the content of LC atoms in Ni.

[Mycology, chemical components, bioactivities, and fermentation process regulation of Sanghuang: a review].

Sanghuang, a famous ethnomedicine widely used in China, Japan, Korea and other countries for a long history, is produced from the dried fruiting bodies of the medical fungi belonging to Sanghuangporus. With abundant bioactive natural chemicals including polysaccharides, flavonoids, triterpenoids, and polyphenols, Sanghuang exhibits anticancer, antioxidant, blood glucose-and lipid-lowering, liver protecting, anti-inflammatory, antimicrobial, and gout symptom-relieving effects, thus demonstrating broad application and development prospects in the pharmaceutical and food fields. However, the sustainable development of Sanghuang resources is limited by the scarce stock of wild resources, the diverse original fungi of cultivated Sanghuang, the inconsistency of local standards of Sanghuang materials or products, and the lagging application of Sanghuangporus mycelia.

Baseline characteristics of patients in the Chinese Bronchiectasis Registry (BE-China): a multicentre prospective cohort study.

Background: Bronchiectasis is a disease with a global impact, but most published data come from high-income countries. We aimed to describe the clinical characteristics of patients with bronchiectasis in China.

Methods: The Chinese Bronchiectasis Registry (BE-China) is a prospective, observational cohort enrolling patients from 111 hospitals in China.

Analysis of the Distribution Pattern and Prophage Types in Asiaticus 'Cuimi' Kumquat.

The 'Cuimi' kumquat is a unique citrus cultivar known for its thin, crisp pulp and sweet, aromatic flavor. In addition to its use in fresh consumption and processing, this variety exhibits certain medicinal properties. This study aims to investigate the genetic diversity of the Huanglongbing (HLB) bacterium across different tissues of the 'Cuimi' kumquat, offering a theoretical basis for understanding the HLB epidemic in Dechang County, Sichuan.

Characterization of Key Lipid Components in the Cell Membrane of Freeze-Drying Resistant Strains Using Nontargeted Lipidomics.

Lactic acid bacteria (LAB) are usually freeze-dried into powder for transportation and storage, with the bacterial membrane playing a crucial role in this process. However, different strains exhibit different levels of freeze-drying resistance in their cell membranes. In this study, () strains 1F20, K56, and J5, demonstrating survival rates of 59.

Insights into the Molecular Mechanisms of Purine Compounds Synergistically Inducing Larval Settlement in Using Multi-Group Comparative Transcriptomic Analysis.

Most benthic marine invertebrates exhibit a characteristic biphasic life cycle, consisting of a planktonic larval stage followed by a benthic adult stage [...

sp. nov., a Al-tolerant bacterium with the ability to inhibit f. sp. isolated from rhizosphere soil of muskmelon.

A bacterial strain, designated as A6, was isolated from the rhizosphere soil of a healthy muskmelon in Wenchang, Hainan Province, China. The cells of strain A6 were Gram-negative, aerobic, short rod and motile with a single polar flagellum. Strain A6 could tolerate up to 55.

Lower limb joint reaction forces during sit-to-stand and stand-to-sit movements in stroke patients with spastic hemiplegia.

Objective: We investigated the characteristics of hip, knee, and ankle joint reaction forces (JRFs) in stroke patients with spastic hemiplegia during sit-to-stand (Si-St) and stand-to-sit (St-Si) movements and explored the relationship between JRFs and joint moments.

Methods: Thirteen stroke patients with spastic hemiplegia and thirteen age-matched healthy subjects were recruited in this study. Three-dimensional motion capture system and force plates were employed to collect kinematic data and ground reaction forces during Si-St and St-Si tasks.

Limnobacter olei sp. nov., a Novel Diesel-Degrading Bacterium Isolated from Oil-Contaminated Soil.

A bacterial strain P1, capable of degrading diesel and converting thiosulfate to sulfate was isolated from an oil-contaminated soil sample. The cells were Gram-stain-negative, slightly curved rods and motile with a single polar flagellum. Growth of the strain was observed at 4-45 °C (optimum at 28 °C), at pH 4.

Machine Learning Approaches in High Myopia: Systematic Review and Meta-Analysis.

Background: In recent years, with the rapid development of machine learning (ML), it has gained widespread attention from researchers in clinical practice. ML models appear to demonstrate promising accuracy in the diagnosis of complex diseases, as well as in predicting disease progression and prognosis. Some studies have applied it to ophthalmology, primarily for the diagnosis of pathologic myopia and high myopia-associated glaucoma, as well as for predicting the progression of high myopia.

Fabrication of emulsion microparticles to improve the physicochemical stability of vitamin A acetate.

Vitamin A is an essential micronutrient crucial for human health, but it is susceptible to degradation when exposed to light, oxygen, and heat, reducing its effectiveness in food production. This study aims to develop vitamin A acetate (VA) emulsion microparticles under an acidic condition using electrostatic complexation and the viscosifying effect to enhance VA physicochemical stability. The stability, encapsulation efficiency (EE), microstructure, and rheological properties of VA emulsion microparticles at different sodium alginate concentrations were investigated.

Phycocyanin-based multifunctional microspheres for treatment of infected radiation-induced skin injury.

Radiation therapy is a primary modality for cancer treatment; however, it often leads to various degrees of skin injuries, ranging from mild rashes to severe ulcerations, for which no effective treatments are currently available. In this study, a multifunctional microsphere (PC@CuS-ALG) was synthesized by encapsulating phycocyanin-templated copper sulfide nanoparticles (PC@CuS) within alginate (ALG) using microfluidic technology. Phycocyanin, a natural protein derived from microalgae, shows abilities to scavenge reactive oxygen species, repair radiation-induced damage to skin cells, and ameliorate macrophage-related inflammatory responses.

Advancing precision medicine in esophageal squamous cell carcinoma using patient-derived organoids.

Background: Patient-derived organoids (PDOs) represent a promising approach for replicating the characteristics of original tumors and facilitating drug testing for personalized treatments across diverse cancer types. However, clinical evidence regarding their application to esophageal cancer remains limited. This study aims to evaluate the efficacy of implementing PDOs in clinical practice to benefit patients with esophageal squamous cell carcinoma (ESCC).

From the microspheres to scaffolds: advances in polymer microsphere scaffolds for bone regeneration applications.

The treatment and repair of bone tissue damage and loss due to infection, tumours, and trauma are major challenges in clinical practice. Artificial bone scaffolds offer a safer, simpler, and more feasible alternative to bone transplantation, serving to fill bone defects and promote bone tissue regeneration. Ideally, these scaffolds should possess osteoconductive, osteoinductive, and osseointegrative properties.

[Mechanism of WAVE1 regulation of lipopolysaccharide-induced mitochondrial metabolic abnormalities and inflammatory responses in macrophages].

Objectives: To explore the mechanism by which Wiskott-Aldrich syndrome protein family verprolin-homologous protein 1 (WAVE1) regulates lipopolysaccharide (LPS)-induced mitochondrial metabolic abnormalities and inflammatory responses in macrophages.

Methods: Macrophage cell lines with overexpressed WAVE1 (mouse BMDM and human THP1 cells) were prepared. The macrophages were treated with LPS (500 ng/mL) to simulate sepsis-induced inflammatory responses.

Mechanism of improved cellulase production by Trichoderma reesei in water-supply solid-state fermentation.

High production cost of cellulases limits its commercial application on lignocellulose. Solid-state fermentation (SSF) has special advantages of water and energy conservation, however, the lack of free water and water loss during fermentation limits its application. In this paper, a constructed water-supply SSF was used to improve carboxymethyl cellulose activity and filter paper activity of 1.

Chitosan-based dihydromyricetin composite hydrogel demonstrating sustained release and exceptional antibacterial activity.

Plant-derived antibacterial agents are increasingly pivotal in mitigating the escalating threat posed by pathogenic microorganisms. Dihydromyricetin (DMY), a plant bioactive compound prevalent in Ampelopsis grossedentata, exhibits remarkable antibacterial properties. However, its poor solubility in water significantly hinders its application in antibacterial therapies, necessitating the exploration of suitable carriers for the loading and sustained release of DMY.

Impact of ground-glass component on prognosis in early-stage lung cancer treated with stereotactic body radiotherapy via Helical Tomotherapy.

Purpose: This study aims to investigate the prognostic impact of ground-glass opacity (GGO)-component in early-stage lung cancer patients treated with stereotactic body radiotherapy (SBRT).

Methods: From January 2013 to December 2022, 239 early-stage lung cancer patients (T1-2N0M0) underwent SBRT. They were categorized into two groups based on the presence of GGO-component: 65 patients in the subsolid group with a consolidation tumor ratio (CTR) between 0.

Continuous renal replacement therapy with adsorbing filter oXiris in the treatment of sepsis associated acute kidney injury: a single-center retrospective observational study.

Background And Objective: Critical bedside ultrasound is widely used in clinical practice, and it can monitor renal perfusion. The reduction of renal perfusion and inflammatory injury are two contributing factors to sepsis-associated acute kidney injury (SA-AKI).The aim of this study was to examine whether the oXiris filter was useful in the continuous renal replacement therapy(CRRT) treatment of SA-AKI patients.

A multimodal deep-learning model based on multichannel CT radiomics for predicting pathological grade of bladder cancer.

Objective: To construct a predictive model using deep-learning radiomics and clinical risk factors for assessing the preoperative histopathological grade of bladder cancer according to computed tomography (CT) images.

Methods: A retrospective analysis was conducted involving 201 bladder cancer patients with definite pathological grading results after surgical excision at the organization between January 2019 and June 2023. The cohort was classified into a test set of 81 cases and a training set of 120 cases.

Novel insights into non-coding RNAs and their role in hydrocephalus.

A large body of evidence has highlighted the role of non-coding RNAs in neurodevelopment and neuroinflammation. This evidence has led to increasing speculation that non-coding RNAs may be involved in the pathophysiological mechanisms underlying hydrocephalus, one of the most common neurological conditions worldwide. In this review, we first outline the basic concepts and incidence of hydrocephalus along with the limitations of existing treatments for this condition.

Subanesthetic propofol alleviates chronic stress-induced anxiety by enhancing VTADA neurons' activity.

Anxiety, a common mental disorder, imposes significant clinical and economic burdens. Previous studies indicate that propofol has anxiolytic effects at anesthetic doses. However, the risks associated with general anesthesia limit its application in anxiety treatment.