Publications by authors named "Hazem Ghaith"
Background: The discontinuation and non-publication of clinical studies in various medical fields undermine research efforts and may bias the medical evidence base. This study investigates the prevalence and factors associated with these issues in endovascular stroke studies.
Methods: Clinical Trials.
Background: Chronic subdural hematoma (cSDH) is increasingly prevalent in the elderly and traditionally treated with surgical interventions. Middle meningeal artery embolization (MMAE) has emerged as an adjunctive therapy to reduce recurrence rates. Transfemoral access (TFA) is the conventional route for neuroendovascular procedures, but transradial access (TRA) offers potential advantages, including reduced access-site complications, earlier ambulation, and shorter hospital stays.
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- Preventing rebleeding in aneurysmal subarachnoid hemorrhage (SAH) is important, and lowering systolic blood pressure (SBP) may help, although evidence is not clear-cut.
- A systematic review analyzed ten studies, finding that higher SBP is linked to a greater chance of rebleeding, while maintaining SBP ≤160 mmHg reduced this risk significantly.
- The results should be approached cautiously due to variability in study designs, highlighting the need for more standardized future research to better understand blood pressure's role in rebleeding risk.
Article Synopsis
- Recent research suggests that endovascular therapy (EVT) may be a viable alternative to traditional anticoagulation treatments for cerebral sinus venous thrombosis (CSVT).
- A systematic review of 38 studies involving 682 patients showed high rates of favorable outcomes, with 82.6% achieving a modified Rankin Scale score of 0-2 and a 60.9% rate of complete recanalization.
- The study also highlighted a relatively low mortality rate of 6.7% and minimal new hematoma formation, indicating that EVT has a promising safety profile, but further studies are needed for conclusive results.
Background & Objectives: Rigid ring and Flexible band are techniques used to repair tricuspid valve regurgitation. The comparison between both techniques' effectiveness is controversial in the literature. We conducted this systematic review and meta-analysis to compare the safety and efficacy of rigid ring versus flexible band for tricuspid valve repair in patients with tricuspid valve regurgitation.
View Article and Find Full Text PDFInsomnia, as a difficulty in initiating and maintaining sleep, coupled with cardiovascular diseases (CVDs) increase the risk of aggravate daytime symptoms, mortality, and morbidity. Cognitive behavioral therapy (CBT) is thought to have a significant impact on insomnia treatment, but in patients with CVDs, there is a paucity of data. To provide a comprehensive appraisal on the impact of CBT on the treatment of insomnia in patients with CVDs.
View Article and Find Full Text PDFBackground: Recent studies indicate endovascular thrombectomy (EVT) as a safe, effective treatment for acute ischemic stroke (AIS) with large ischemic regions. Our study updates an ongoing living systematic review and meta-analysis of randomized controlled trials (RCTs) comparing outcomes of EVT to medical management only.
Methods: We searched MEDLINE, EMBASE, and the Cochrane Library for RCTs comparing EVT to medical management in AIS patients with large ischemic areas.
Background: Aneurysmal subdural hematoma (aSDH) is a rare complication of aneurysm rupture, affecting between 0.5 and 7.9% of patients with aneurysmal subarachnoid hemorrhage (aSAH).
View Article and Find Full Text PDFBackground: Invasive revascularization is recommended for cohorts of patients with ST-elevation myocardial infarction (STEMI) and non-ST-elevation acute coronary syndrome (NSTE-ACS). However, the optimal timing of invasive revascularization is still controversial and no defined consensus is established. We aim to give a comprehensive appraisal on the optimal timing of invasive strategy in the heterogenous population of ACS.
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- Interventional cardiologists often struggle with chronic total occlusion (CTO) lesions, and this meta-analysis compares the effectiveness of rotational atherectomy (RA) to conventional percutaneous coronary intervention (PCI).
- A review of seven studies with over 5,400 patients found that RA and PCI had similar rates of major adverse cardiovascular events (MACE) and other clinical outcomes over an average follow-up of 43 months.
- The results suggest that RA is as effective as conventional PCI for CTO lesions, providing cardiologists with more options for treating calcified lesions.
Background: Drug-coated balloons (DCBs) are an established strategy for coronary artery disease. However, the new generation drug-eluting stent (DES) is recommended for patients with Acute myocardial infarction (AMI) for coronary artery revascularization. Our aim is to provide a comprehensive appraisal of the efficacy of DCBs in patients with AMI undergoing PCI.
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- Alzheimer's disease (AD) is a widespread type of dementia marked by neurodegeneration and memory problems, primarily caused by the buildup of misfolded proteins like amyloid plaques and tau tangles.
- The disease can occur as early-onset or late-onset AD, each linked to different genetic factors, with the RIN3 gene being significant in both types.
- RIN3 contributes to AD by causing endosomal dysfunction, influencing the transport of substances across the blood-brain barrier, and affecting immune responses through the PTK2B gene.
Article Synopsis
- This study aimed to assess how cerebral microbleeds (CMBs) affect outcomes for stroke patients undergoing endovascular thrombectomy (EVT), focusing on functional independence and safety.
- Using a systematic review approach, researchers analyzed four studies with 1,514 patients and found that the presence of CMBs significantly reduced the chances of achieving positive functional outcomes after EVT.
- However, CMBs had no effect on successful revascularization rates, mortality, or the occurrence of various hemorrhagic complications, indicating a specific impact of CMBs on functional recovery rather than overall safety.
The use of percutaneous coronary intervention (PCI) in patients with chronic total occlusion (CTO) is still a subject of debate, with conflicting outcomes reported in different studies when compared to non-CTO lesions. This meta-analysis aims to clarify the clinical outcomes of PCI in CTO cases compared to non-CTO lesions, both in the short and long-term. PubMed, Scopus, Web of Science, Ovid, and Cochrane Central were searched until March 2023 for relevant studies addressing short- and long-term outcomes of PCI in CTO vs non-CTO lesions.
View Article and Find Full Text PDFBackground And Purpose: New studies have shown that endovascular thrombectomy (EVT) is safe and effective for acute ischemic stroke (AIS) patients with large ischemic areas. The aim of our study is to conduct a living systematic review and meta-analysis of randomized trials comparing EVT versus medical management only.
Methods: We searched MEDLINE, Embase, and the Cochrane Library to identify randomized controlled trials (RCTs) comparing EVT versus medical management alone in AIS patients with large ischemic regions.
Article Synopsis
- Endovascular thrombectomy (EVT) is the primary treatment for acute ischemic stroke due to large vessel occlusion, but only about one-third of patients achieve good outcomes, partly due to the "no-reflow" phenomenon affecting blood circulation.
- A meta-analysis was conducted to evaluate the effectiveness of combining EVT with intra-arterial (IA) tissue plasminogen activator (tPA) in improving patient outcomes.
- The analysis revealed no significant differences in successful recanalization, functional independence, or risk of symptomatic intracranial hemorrhage between the EVT alone and the EVT plus IA tPA groups, indicating the need for further randomized controlled trials.
Article Synopsis
- Atrial fibrillation (AF) is a common complication after heart surgery, often linked to fluid buildup in the pericardium (the heart's outer layer).
- This study investigated whether performing a posterior pericardiotomy (PP) during surgery could reduce the incidence of postoperative AF compared to not performing it.
- Results from 25 clinical trials showed that patients who had PP experienced significantly lower rates of AF and related complications, leading to shorter hospital stays and suggesting that PP is both effective and cost-efficient.
Purpose: To assess the impact of the COVID-19 pandemic on the outcomes of the patients who underwent trauma surgery during the peak of the pandemic.
Methods: The UKCoTS collected the postoperative outcomes of consecutive patients who underwent trauma surgery across 50 centres during the peak of the pandemic (April 2020) and during April 2019.
Results: Patients who were operated on during 2020 were less likely to be followed up within a 30-day postoperative period (57.
Background And Aim: COVID-19 has shown how crucial awareness of the need to protect public health is to global security. Antibiotic resistance due to antibiotic misuse is seen as a worldwide health issue. Antibiotic use was significant during the COVID-19 epidemic, according to several nations.
View Article and Find Full Text PDFAcute kidney injury (AKI) is a prevalent medical condition accompanied by mutual affection of other organs, including the liver resulting in complicated multiorgan malfunction. Macrophages play a vital role during tissue injury and healing; they are categorized into "classically activated macrophages" (M1) and "alternatively activated macrophages" (M2). The present study investigated and compared the conventional fluid therapy Dipeptidyl peptidase 4 inhibitor (DPP-4i) vildagliptin on the liver injury induced by AKI and evaluated the possible molecular mechanisms.
View Article and Find Full Text PDFBackground: Dementia is a neurological disorder that commonly affects the elderly. Cerebral microbleeds (CMBs) are small, tiny lesions of the cerebral blood vessels and have been suggested as a possible risk factor for dementia. However, data about the association between CMBs and dementia risk are inconsistent and inconclusive.
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