Publications by authors named "Hazel O'Neill"
Background: Demand for inpatient MRI outstrips capacity which results in long waiting lists. The hospital commenced a routine weekend MRI service in January 2023.
Aim: The aim of this study was to investigate the effect of a limited routine weekend MRI service on MRI turnaround times.
Air Embolism Complicating Percutaneous Biopsy of a Cystic Lung Mass.
J Vasc Interv Radiol
February 2024
Introduction: Acute abdominal pain accounts for 5% of all presentations to the emergency department (Stoker et al., 2009). Two of the most common causes are acute appendicitis and acute cholecystitis (Ferris et al.
View Article and Find Full Text PDFA twisted tale-radiological imaging features of COVID-19 on F-FDG PET/CT.
Eur J Hybrid Imaging
July 2020
The COVID-19 pandemic has had a major impact on health care systems across the globe in a short period of time. There is a growing body of evidence surrounding the findings on hybrid imaging with FDG-PET/CT, and this case highlights the importance of molecular imaging in better understanding of the biomarkers of the disease which ultimately determine the success in building a model to predict the disease severity and monitoring the response to treatment.
View Article and Find Full Text PDFCharacterizing caspase-1 involvement during esophageal disease progression.
Cancer Immunol Immunother
December 2020
Article Synopsis
- Barrett's esophagus (BE) is an inflammatory condition that can lead to esophageal adenocarcinoma (EAC) and is linked to caspase-1 signaling, which is important for inflammatory responses.
- This study investigated how caspase-1 expression changes during the progression from normal esophageal tissue to BE and eventually to EAC using three models: a human cell line, a mouse model, and patient tissue samples.
- The results showed that caspase-1 activity is significantly higher in BE tissues, and inhibiting caspase-1 reduced the secretion of inflammatory markers, suggesting that targeting this protein could help manage inflammation and disease progression in BE patients.
Targeting hallmarks of cancer to enhance radiosensitivity in gastrointestinal cancers.
Nat Rev Gastroenterol Hepatol
May 2020
Radiotherapy is used in the treatment of approximately 50% of all malignancies including gastrointestinal cancers. Radiation can be given prior to surgery (neoadjuvant radiotherapy) to shrink the tumour or after surgery to kill any remaining cancer cells. Radiotherapy aims to maximize damage to cancer cells, while minimizing damage to healthy cells.
View Article and Find Full Text PDFPositron Emission Tomography (PET) is a functional imaging modality widely used in clinical oncology. Over the years the sensitivity and specificity of PET has improved with the advent of specific radiotracers, increased technical accuracy of PET scanners and incremental experience of Radiologists. However, significant limitations exist-most notably false positives and false negatives.
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