Regeneration following tissue necrosis is mediated by non-apoptotic caspase activity.

Tissue necrosis is a devastating complication for many human diseases and injuries. Unfortunately, our understanding of necrosis and how it impacts surrounding healthy tissue - an essential consideration when developing effective methods to treat such injuries - has been limited by a lack of robust genetically tractable models. Our lab previously established a method to study necrosis-induced regeneration in the wing imaginal disc, which revealed a unique phenomenon whereby cells at a distance from the injury upregulate caspase activity in a process called Necrosis-induced Apoptosis (NiA) that is vital for regeneration.

Assessment of a Peer Support Group Intervention for Undocumented Latinx Immigrants With Kidney Failure.

Importance: Most undocumented immigrants with kidney failure rely on emergency dialysis (defined as dialysis after a patient presents as critically ill) and experience significant depression and anxiety and high mortality. Culturally and language-concordant peer support group interventions may be associated with reduced depression and anxiety and may provide emotional support.

Objective: To investigate the feasibility and acceptability of a single-group peer support group intervention.

Perspectives of Latinx Individuals Who Were Unvaccinated And Hospitalized for COVID-19: A Qualitative Study.

Importance: Latinx individuals in the United States have lower COVID-19 vaccination rates and higher rates of COVID-19 infections, hospitalizations, and deaths than non-Latinx White individuals. Little is known about the perspectives of Latinx adults who had not received the COVID-19 vaccination and were hospitalized for COVID-19.

Objective: To describe the perspectives of Latinx individuals who were unvaccinated and subsequently hospitalized for COVID-19.

Systematic review of cost-effectiveness analysis of behavior change communication apps: Assessment of key methods.

Objective: Evidence backing the effectiveness of mobile health technology is growing, and behavior change communication applications (apps) are fast becoming a useful platform for behavioral health programs. However, data to support the cost-effectiveness of these interventions are limited. Suggestions for overcoming the low output of economic data include addressing the methodological challenges for conducting cost-effectiveness analysis of behavior change app programs.

Thriving with Down syndrome: A qualitative multiple case study.

Background: Down syndrome (DS) is the most common genetic cause of intellectual disability. Prior research has primarily focused on associated medical problems and skill deficits. This study takes a novel positive psychology approach by examining critical individual characteristics and environmental factors that facilitate exceptional quality of life for people with DS.

Predicting visual outcomes in patients treated with aflibercept for neovascular age-related macular degeneration: Data from a real-world clinical setting.

Background/objectives: There is a significant variation in the way neovascular age-related macular degeneration patients respond to anti-vascular endothelial growth factor treatment. Both the financial and time cost of treatment are significant. As such, being able to predict patient response to treatment is valuable.

Results of a Dutch national and subsequent international expert meeting on interconception care.

The potential value of preconception care and interconception care is increasingly acknowledged, but delivery is generally uncommon. Reaching women for interconception care is potentially easier than for preconception care, however the concept is still unfamiliar. Expert consensus could facilitate guidelines, policies and subsequent implementation.

Race, Exclusionary Discipline, and Connectedness to Adults in Secondary Schools.

This study examines racial differences in students' connectedness to school adults and considers the possibility that disparities in exclusionary discipline practices may reduce all students' sense of connection to educators, not just those who have been disciplined or are from racial groups overrepresented in out-of-school suspensions. Data sources include a self-report survey of secondary school students (n = 29,148) linked to administrative data (n = 107 schools) from a large urban district. Multilevel modeling techniques were used to estimate the relationships between students' racial background, youths' connection to school adults, and school-level racial discipline gaps.

Mapping the use of research to support strategies tackling maternal and child health inequities: evidence from six countries in Africa and Latin America.

Background: Striving to foster collaboration among countries suffering from maternal and child health (MCH) inequities, the MASCOT project mapped and analyzed the use of research in strategies tackling them in 11 low- and middle-income countries. This article aims to present the way in which research influenced MCH policies and programs in six of these countries - three in Africa and three in Latin America.

Methods: Qualitative research using a thematic synthesis narrative process was used to identify and describe who is producing what kind of research, how research is funded, how inequities are approached by research and policies, the countries' research capacities, and the type of evidence base that MCH policies and programs use.

South Asian diabetic macular oedema treated with ranibizumab (ADMOR)-real-life experience.

PURPOSE Diabetic macular oedema (DMO) is a leading cause for visual impairment in the working age population in the UK. Ranibizumab has been shown to be effective in treatment of DMO in studies based on mainly Caucasian populations. This study reports the 12-month outcome in a cohort of South Asian subjects with DMO treated with ranibizumab.

Evidence of convergent and discriminant validity of the Student School Engagement Measure.

The purpose of this study was to investigate the convergent and discriminant validity of the Student School Engagement Measure (SSEM) with 3 other measures of student well-being: (a) the School Engagement Scale, (b) the Student Engagement Instrument, and (c) the Student Life Satisfaction Survey. The data were analyzed from 370 8th-grade students from 3 middle schools in an urban school district. As hypothesized, strong and significant positive correlations (.

Registered nurse perceptions after implementation of a nurse residency program.

Nurse residency programs (NRPs) are an effective mechanism for transitioning newly licensed registered nurses (NLRNs) to practice. No studies have investigated how experienced nurses view NLRN performance after NRPs. The purpose of this quality initiative was to identify experienced nurses' satisfaction with NLRN proficiency before and after implementation of an NRP using the Nursing Practice Readiness Tool.

Distribution of Fusarium mycotoxins in UK wheat mill fractions.

The EU has set maximum limits for the Fusarium mycotoxins, deoxynivalenol (DON) and zearalenone (ZON). The maximum permitted level decreases from unprocessed wheat, through intermediary products, e.g.

New multiple-herbicide crop resistance and formulation technology to augment the utility of glyphosate.

Glyphosate has performed long and well, but now some weed communities are shifting to populations that survive glyphosate, and growers need new weed management technologies to augment glyphosate performance in glyphosate-resistant crops. Unfortunately, most companies are not developing any new selective herbicides with new modes of action to fill this need. Fortunately, companies are developing new herbicide-resistant crop technologies to combine with glyphosate resistance and expand the utility of existing herbicides.

Static accommodative responses following adaptation to differential levels of blur.

Purpose: To investigate the effects of two levels of blur adaptation on visual resolution and steady-state accommodation responses in emmetropes and myopes.

Methods: Eleven emmetropes (mean refractive error +0.01 +/- 0.

Retaining and recruiting mature experienced nurses: a multicomponent organizational strategy.

The aging and impending retirement of the nursing work force will worsen the nursing shortage. Because nurses retire for a variety of reasons, retaining older nurses or delaying their retirement requires a multifactorial method. The authors describe one medical center's multifaceted approach and subsequent strategies to create a work environment conducive to retaining the mature, experienced nurse.

Influence of processing on trichothecene levels.

Trichothecene mycotoxins frequently occur in cereal grains that are intended for food production. The process of converting grains into food and drinks for consumers has significant effects on the levels of toxins in the final food. Surveillance of retail food and drinks of cereal origin demonstrates that trichothecenes do survive the production processes employed.

The usefulness of Vistech and FACT contrast sensitivity charts for cataract and refractive surgery outcomes research.

Aim: To investigate the repeatability and sensitivity of two commonly used sine wave patch charts for contrast sensitivity (CS) measurement in cataract and refractive surgery outcomes.

Methods: The Vistech CS chart and its descendant, the Functional Acuity Contrast Test (FACT), were administered in three experiments: (1) Post-LASIK and age matched normal subjects; (2) Preoperative cataract surgery and age matched normal subjects; (3) Test-retest repeatability data in normal subjects.

Results: Contrast sensitivity was similar between post-LASIK and control groups and between the Vistech and FACT charts.

Open- and closed-loop regressions compared in myopic and emmetropic subjects.

Post-near task accommodation regressions have been measured in a number of studies to investigate the association between myopia and nearwork. The slow nature of the regression found when measuring both open- and closed-loop regressions in some subjects has been hypothesised to be associated with myopia development and progression. However, it is not known whether the speed and characteristics of the regression for an individual is the same under open- and closed-loop conditions.

Wavefront aberration and its relationship to the accommodative stimulus-response function in myopic subjects.

Background: Autorefractors are increasingly used in myopia research because they are convenient tools to investigate aspects of the accommodation response. The degree to which the autorefractor measures are affected by ocular aberrations has been highlighted by studies that have shown changes in aberration levels through different parts of the pupil and with accommodation. We have compared accommodative accuracy as measured with a Shin-Nippon SRW 5000 autorefractor with wavefront error as measured with a Hartmann-Shack wavefront sensor to investigate how factors such as accommodation demand, ocular aberrations, and pupil size can influence autorefractor measures.

The dependency of logMAR visual acuity measurements on chart design and scoring rule.

Background: Visual acuity, increasingly measured using a logarithm of the minimum angle of resolution (logMAR) chart, is the "gold standard" by which the outcomes of the vast majority of clinical trials or interventions are judged. To allow comparison of results across studies, it is important that different charts provide equivalent results.

Methods: In a first experiment, we compared corrected visual acuity measurements from four different logMAR charts (Bailey-Lovie, ETDRS, Regan, and Waterloo).

Visual function and subjective quality of life compared in subjects with acquired macular disease.

Purpose: To determine the objective measures of visual function that are most relevant to subjective quality of vision and perceived reading ability in patients with acquired macular disease.

Methods: Twenty-eight patients with macular disease underwent a comprehensive assessment of visual function. The patients also completed a vision-related quality-of-life questionnaire that included a section of general questions about perceived visual performance and a section with specific questions on reading.

Reading with eccentric fixation is faster in inferior visual field than in left visual field.

Purpose: People with central field loss tend to fixate so that information falls in the inferior or left visual field. Studies of reading from a page of text suggest that using inferior field is advantageous relative to using left visual field. In this study, we investigated whether reading without eye movements in normal peripheral vision is better when text is presented in inferior or left visual field.