Tissue-resident memory T cells in epicardial adipose tissue comprise transcriptionally distinct subsets that are modulated in atrial fibrillation.

Atrial fibrillation (AF) is the most common sustained arrhythmia and carries an increased risk of stroke and heart failure. Here we investigated how the immune infiltrate of human epicardial adipose tissue (EAT), which directly overlies the myocardium, contributes to AF. Flow cytometry analysis revealed an enrichment of tissue-resident memory T (T) cells in patients with AF.

Carotid body dysregulation contributes to Long COVID symptoms.

Background: The symptoms of long COVID, which include fatigue, breathlessness, dysregulated breathing, and exercise intolerance, have unknown mechanisms. These symptoms are also observed in heart failure and are partially driven by increased sensitivity of the carotid chemoreflex. As the carotid body has an abundance of ACE2 (the cell entry mechanism for SARS-CoV-2), we investigated whether carotid chemoreflex sensitivity was elevated in participants with long COVID.

Aging in females is associated with changes in respiratory modulation of sympathetic nerve activity and blood pressure.

Sympathetic nerve activity (SNA) is tightly coupled with the respiratory cycle. In healthy human males, respiratory modulation of SNA does not change with age. However, it is unclear how this modulation is affected by age in females.

Pro-inflammatory role of Wnt/β-catenin signaling in endothelial dysfunction.

Background: Endothelial dysfunction is a critical component of both atherosclerotic plaque formation and saphenous vein graft failure. Crosstalk between the pro-inflammatory TNF-α-NFκB signaling axis and the canonical Wnt/β-catenin signaling pathway potentially plays an important role in regulating endothelial dysfunction, though the exact nature of this is not defined.

Results: In this study, cultured endothelial cells were challenged with TNF-α and the potential of a Wnt/β-catenin signaling inhibitor, iCRT-14, in reversing the adverse effects of TNF-α on endothelial physiology was evaluated.

Phonological parafoveal pre-processing in children reading English sentences.

Although previous research has shown that, in English, both adult and teenage readers parafoveally pre-process phonological information during silent reading, to date, no research has been conducted to investigate such processing in children. Here we used the boundary paradigm during silent sentence reading, to ascertain whether typically developing English children, like adults, parafoveally process words phonologically. Participants' eye movements (adults: n = 48; children: n = 48) were recorded as they read sentences which contained, in preview, correctly spelled words (e.

The importance of the first letter in children's parafoveal preprocessing in English: Is it phonologically or orthographically driven?

For both adult and child readers of English, the first letter of a word plays an important role in lexical identification. Using the boundary paradigm during silent sentence reading, we examined whether the first-letter bias in parafoveal preprocessing is phonologically or orthographically driven and whether this differs between skilled adult and beginner child readers. Participants read sentences that contained either a correctly spelled word in preview (identity; e.

Obesity and diabetes are major risk factors for epicardial adipose tissue inflammation.

BACKGROUNDEpicardial adipose tissue (EAT) directly overlies the myocardium, with changes in its morphology and volume associated with myriad cardiovascular and metabolic diseases. However, EAT's immune structure and cellular characterization remain incompletely described. We aimed to define the immune phenotype of EAT in humans and compare such profiles across lean, obese, and diabetic patients.

Aneurysm severity is suppressed by deletion of CCN4.

Patients with abdominal aortic aneurysms are frequently treated with high-risk surgery. A pharmaceutical treatment to reverse aneurysm progression could prevent the need for surgery and save both lives and healthcare resources. Since CCN4 regulates cell migration, proliferation and apoptosis, processes involved in aneurysm progression, it is a potential regulator of aneurysm progression.

Eye-movement control during learning and scanning of English pseudoword stimuli: Exposure frequency effects and spacing effects in a visual search task.

Wang et al. (Attention, Perception, and Psychophysics, in press, 2021) reported a Landolt-C learning and scanning experiment. In a learning session, they simulated exposure frequency effects successfully by training participants to learn target Landolt-C clusters with different exposures.

Eye-movement control during learning and scanning of Landolt-C stimuli: Exposure frequency effects and spacing effects in a visual search task.

We examined whether typical frequency effects observed in normal reading would also occur in a target search task using non-linguistic Landolt-C stimuli. In an initial learning session, we simulated development of frequency effects by controlling exposures participants received of Landolt-C clusters during learning. In a subsequent scanning session, we manipulated the cluster demarcation form of linear strings of Landolt-C clusters (i.

The influence of children's reading ability on initial letter position encoding during a reading-like task.

Previous studies exploring the cost of reading sentences with words that have two transposed letters in adults showed that initial letter transpositions caused the most disruption to reading, indicating the important role that initial letters play in lexical identification (e.g., Rayner et al.

HIF1α activation in dendritic cells under sterile conditions promotes an anti-inflammatory phenotype through accumulation of intracellular lipids.

Obesity is among the leading causes of elevated cardiovascular disease mortality and morbidity. Adipose tissue dysfunction, insulin resistance and inflammation are recognized as important risk factors for the development of cardiovascular disorders in obesity. Hypoxia appears to be a key factor in adipose tissue dysfunction affecting not only adipocytes but also immune cell function.

Parafoveal pre-processing in children reading English: The importance of external letters.

Although previous research has demonstrated that for adults external letters of words are more important than internal letters for lexical processing during reading, no comparable research has been conducted with children. This experiment explored, using the boundary paradigm during silent sentence reading, whether parafoveal pre-processing in English is more affected by the manipulation of external letters or internal letters, and whether this differs between skilled adult and beginner child readers. Six previews were generated: identity (e.

The role of phonology in lexical access in teenagers with a history of dyslexia.

We examined phonological recoding during silent sentence reading in teenagers with a history of dyslexia and their typically developing peers. Two experiments are reported in which participants' eye movements were recorded as they read sentences containing correctly spelled words (e.g.

The Changing Role of Phonology in Reading Development.

Processing of both a word's orthography (its printed form) and phonology (its associated speech sounds) are critical for lexical identification during reading, both in beginning and skilled readers. Theories of learning to read typically posit a developmental change, from early readers' reliance on phonology to more skilled readers' development of direct orthographic-semantic links. Specifically, in becoming a skilled reader, the extent to which an individual processes phonology during lexical identification is thought to decrease.

Reading sentences of words with rotated letters: An eye movement study.

Participants' eye movements were measured as they read sentences in which individual letters within words were rotated. Both the consistency of direction and the magnitude of rotation were manipulated (letters rotated all in the same direction, or alternately clockwise and anti-clockwise, by 30° or 60°). Each sentence included a target word that was manipulated for frequency of occurrence.

Comments on: "What Is Developmental Dyslexia?" Brain Sci. 2018, 8, 26. The Relationship between Eye Movements and Reading Difficulties.

We are writing in response to the review article: Stein. J. (2018).

Binocular advantages for parafoveal processing in reading.

During reading, binocular visual input results in superior performance and is particularly important in the pre-processing of parafoveal text prior to direct fixation. It is not yet clear whether binocular vision in the parafovea is necessary for accurate saccadic targeting, or for efficient pre-processing of upcoming text, prior to direct fixation. In the present sentence reading experiment, we used a dichoptic gaze-contingent moving window paradigm in order to establish 1) how much parafoveal binocular input is necessary for fluent reading and 2) which aspect of parafoveal processing is more reliant on binocular vision.

Phonological processing during silent reading in teenagers who are deaf/hard of hearing: an eye movement investigation.

There has been considerable variability within the literature concerning the extent to which deaf/hard of hearing individuals are able to process phonological codes during reading. Two experiments are reported in which participants' eye movements were recorded as they read sentences containing correctly spelled words (e.g.

The role of character positional frequency on Chinese word learning during natural reading.

Readers' eye movements were recorded to examine the role of character positional frequency on Chinese lexical acquisition during reading and its possible modulation by word spacing. In Experiment 1, three types of pseudowords were constructed based on each character's positional frequency, providing congruent, incongruent, and no positional word segmentation information. Each pseudoword was embedded into two sets of sentences, for the learning and the test phases.

Using a dichoptic moving window presentation technique to investigate binocular advantages during reading.

Reading comes with a clear binocular advantage, expressed in shorter fixation times and fewer regressions in binocular relative to monocular visual presentations. Little is known, however, about whether the cost associated with monocular viewing derives primarily from the encoding of foveal information or in obtaining a preview benefit from upcoming parafoveal text. In the present sentence reading eye tracking experiment, the authors used a novel dichoptic binocular gaze-contingent moving window technique to selectively manipulate the amount of text made available to the reader both binocularly and monocularly in the fovea and parafovea on a fixation-by-fixation basis.

Parafoveal preprocessing of word initial trigrams during reading in adults and children.

Although previous research has shown that letter position information for the first letter of a parafoveal word is encoded less flexibly than internal word beginning letters (Johnson, Perea & Rayner, 2007; White et al., 2008), it is not clear how positional encoding operates over the initial trigram in English. This experiment explored the preprocessing of letter identity and position information of a parafoveal word's initial trigram by adults and children using the boundary paradigm during normal sentence reading.

An inhibitory influence of transposed-letter neighbors on eye movements during reading.

Previous research has shown that prior exposure to a word's substitution neighbor earlier in the same sentence can disrupt processing of that word, indicating that interword lexical priming occurs naturally during reading, due to the competition between lexical candidates during word identification. Through the present research, we extended these findings by investigating the effects of prior exposure to a word's transposed-letter neighbor (TLN) earlier in a sentence. TLNs are constituted from the same letters, but in different orders.

Beyond decoding: phonological processing during silent reading in beginning readers.

In this experiment, the extent to which beginning readers process phonology during lexical identification in silent sentence reading was investigated. The eye movements of children aged seven to nine years and adults were recorded as they read sentences containing either a correctly spelled target word (e.g.