Synthesis of π-Extended Imidazo[1,2-]quinolines via Carboxylic Acid-Assisted Ru(II)-Catalyzed Dual C-H Activation and Alkyne Annulation.

Ru(II)-catalyzed, carboxylic acid-assisted oxidative annulation of -aryl azoles with alkynes via double C-H activation to produce highly functionalized π-extended imidazo[1,2-]quinolines is reported. The reaction features a broad substrate generality and tolerates various biologically relevant scaffolds. Interestingly, annulated products showed strong fluorescence properties and an AgIE effect and exhibited a selective fluorescent response toward the Cu ion.

Analyzing the clinical efficacy and safety of levocetirizine based on its receptor occupancy, intraclass comparison and role in the treatment of CSU: an AROG consensus statement.

Introduction: Chronic spontaneous urticaria (CSU) is characterized by urticaria persisting for more than 6 weeks. Antihistamines, notably sgAH (second generation antihistamines) are the first line of treatment for CSU.

Areas Covered: This consensus aimed to review the existing research on receptor occupancy of antihistamines, including levocetirizine, and translate its implications in the treatment of CSU.

Hypothalamus-pituitary-adrenal axis (HPA axis) suppression with inappropriate use of steroids in recalcitrant dermatophytosis - A cross-sectional study.

Background: Improper use of over-the-counter (OTC) steroid medication has been linked to recalcitrant dermatophytosis. There is proven evidence of HPA axis suppression by the use of long-term oral steroids. This study aims to determine the prevalence and pattern of inappropriate OTC steroid use and its effects on the hypothalamus-pituitary-adrenal (HPA) axis in adults with recalcitrant dermatophytosis.

Ru/O-Catalyzed Oxidative C-H Activation/Alkyne Annulation Using Quinoline-Functionalized NHC as a Directing and Functionalizable Group.

The ruthenium/O-catalyzed oxidative annulation reaction of imidazo[1,5-]quinolin-2-ium salts with alkynes -heterocyclic carbene-directed C-H activation to obtain π-conjugated fused imidazo[1,5-]quinolin-2-ium derivatives is reported. Molecular oxygen has been explored as an economic and clean oxidant and an alternative to metal oxidants. The current protocol exhibits a wide range of substrate scope including bioactive (±)-α-tocopherol derivatives.

Ruthenium(II)-Catalyzed Oxidative Annulation of Imidazo[1,5-a]quinolin-2-iums Salts and Internal Alkynes via C-H Bond Activation.

Ruthenium(II)-catalyzed synthesis of π-conjugated fused imidazo[1,5-a]quinolin-2-ium derivatives have been achieved via C-H activation of quinoline-functionalized NHC (NHC=N-heterocyclic carbene) and oxidative coupling with internal alkynes. The reaction occurred with high efficiency, broad substrate scope, tolerates a wide range of functional groups and utilized into a gram-scale. Synthetic applications of the coupled product have been exemplified in the late-stage derivatization of various highly functionalized scaffolds.

Quality of Life in Psoriasis: A Cross-Sectional Study from North India.

Background: Psoriasis is a chronic inflammatory papulo-squamous disease characterized by multiple remissions and relapses. This study aimed to assess the impact of psoriasis on the quality of life of patients.

Materials And Methods: A hospital-based, cross-sectional study was conducted enrolling 198 adult patients of psoriasis.

Oral isotretinoin with desloratadine compared with oral isotretinoin alone in the treatment of moderate to severe acne: a randomized, assessor-blinded study.

Background: Our aim was to measure the effectiveness of oral isotretinoin with desloratadine compared with oral isotretinoin alone in treating moderate to severe acne at a tertiary care teaching hospital in North India. In this study, 90 patients with moderate to severe acne were enrolled to participate based on their fulfilling the inclusion criteria.

Methods: A randomized, assessor-blinded, parallel-arm study was conducted.

Exploring Climate Change Adaptation Practices and Agricultural Livelihoods among Rice Farmers of the Brahmaputra Valley in Northeast India.

Global climate change has seriously threatened agriculture and connected sectors, especially in developing countries like India. The Brahmaputra Valley in Assam, Northeast India, is vulnerable to climate change due to its agrarian economy, fragile geo-ecological setting, recurrent floods and droughts, and poor socioeconomic conditions of the farmers. The climate-induced hindrances faced by the rice farming community of this region and the local adaptation practices they employ have not been adequately studied.

A review on the surface modification of materials for 3D-printed diagnostic devices.

Three-dimensional (3D) printing in tissue engineering and biosensing of analytes by using biocompatible materials or modifying surface structures is an upcoming area of study. This review discusses three common surface modification techniques, alkaline hydrolysis, UV light photografting, and plasma treatment. Alkaline hydrolysis involves the reaction of an alkaline solution with the surface of a material, causing the surface to develop carboxyl and hydroxyl groups.

Chromium-Catalyzed Cross-Coupling of Methyl Ketones with Cyclic Ketones toward the Selective Synthesis of β-Branched β,γ-Unsaturated Ketones.

Chromium-catalyzed cross-coupling of methyl ketones with cyclic ketones to β-branched β,γ-unsaturated ketones are reported. Interestingly, single-crossed aldol condensation products are formed, even in reactions in which a mixture of products is possible. The reaction is highly chemoselective and regioselective.

Mucocutaneous Findings in Hematolymphoid Neoplasms: An Observational Study.

Background: Cutaneous manifestations of hematological neoplasms can be divided into three broad categories - direct infiltration, paraneoplastic conditions, and those due to the treatment of hematological cancers.

Objectives: To study the frequency and patterns of mucocutaneous manifestations in patients with hematolymphoid neoplasms and those due to chemotherapy.

Materials And Methods: This was an observational study done with 172 patients.

Systemic treatments in Parthenium dermatitis: A systematic review and meta-analysis.

Parthenium dermatitis is the commonest form of plant dermatitis in India, caused by the plant Parthenium hysterophorus. Systemic immunosuppressives are commonly employed in its treatment. However, there is a relative lack of comparative head-to-head trials.

Rescue treatment with intravenous immunoglobulin and amniotic membrane dressing in refractory paediatric pemphigus vulgaris with sepsis.

We report a case of refractory paediatric pemphigus vulgaris with sepsis, treated successfully with intravenous immunoglobulin (IVIG) and amniotic membrane dressing. The patient was initially started on oral prednisolone (1 mg/kg/day) and dapsone 50 mg once daily. Azathioprine 50 mg orally was then used in place of dapsone due to rapid disease progression with extensive skin involvement.

Heavy Load of Intestinal Fluke in a Four-Year-Old Child with Severe Acute Malnutrition: A Case Report.

Fasciolopsiasis, a food-borne intestinal parasitosis, occurs focally, and remains a significant public health problem in endemic areas. However, due to the wide spectrum of clinical presentation and unclear diagnosis or even misdiagnosis, it often goes unreported. The correlation between trematode infection and malnutrition is also often debated.

Steroid abuse, quality of life, and various risk factors in dermatophytosis: a cross-sectional observational study from a tertiary care center in northern India.

Introduction: Dermatophytosis is a superficial cutaneous mycosis and is steadily progressing to epidemic proportions in India. Various factors such as steroid overuse and misuse are currently making its treatment challenging. The study examines various sociodemographic characteristics, clinical factors, and steroid abuse in patients with dermatophytosis and also assess their quality of life (QOL).