Effect of intravenous nitroglycerin therapy on erythrocyte antioxidant enzymes.

Intravenous nitroglycerin (GTN) has been used as an anti-ischemic agent for the therapy of unstable and post-infarction angina. Nitric oxide (NO) and S-nitrosothiols constitute the biologically active species formed via nitroglycerin bioactivation. Increased levels of reactive oxygen species can diminish the therapeutic action of organic nitrates by scavenging donated NO and oxidizing tissue thiols important in nitrate biotransformation.

[Peptic ulcer perforation: an analysis of risk factors].

Background: Despite decreasing incidence of peptic ulcer disease, peptic ulcer perforation remains a source of mortality. This retrospective study was performed to find riskfactors for mortality and to construct a score that predict outcome for patients with peptic ulcer perforation.

Methods: A review of94 patients operated (primer ciosure and omentoplasty) for perforated peptic ulcer in Iast ten years was undertaken to study.