Association between Genetic Polymorphisms and Bleeding in Patients on Direct Oral Anticoagulants.

: The purpose of our study is to investigate the effects of apolipoprotein B () and gene polymorphisms on bleeding complications in patients receiving direct oral anticoagulants (DOACs). : A total of 16 single nucleotide polymorphisms (SNPs) in 468 patients were genotyped. Six SNPs of (rs3842, rs1045642, rs2032582, rs1128503, rs3213619, and rs3747802), one SNP of (rs776746), seven SNPs of (rs1042034, rs2163204, rs693, rs679899, rs13306194, rs13306198, and rs1367117), and two SNPs of (rs429358 and rs7412) were analyzed by a TaqMan genotyping assay.

Effect of ITPA Polymorphism on Adverse Drug Reactions of 6-Mercaptopurine in Pediatric Patients with Acute Lymphoblastic Leukemia: A Systematic Review and Meta-Analysis.

6-Mercaptopurine (6-MP) is a cornerstone of the maintenance regimen for pediatric acute lymphoblastic leukemia (ALL). Inosine triphosphate pyrophosphatase (ITPA) is considered a candidate pharmacogenetic marker that may affect metabolism and 6-MP-induced toxicities; however, the findings are inconsistent. Therefore, we attempted to evaluate the effect of ITPA 94C>A polymorphism on 6-MP-induced hematological toxicity and hepatotoxicity through a systematic review and meta-analysis.

The Association between ABCG2 421C>A (rs2231142) Polymorphism and Rosuvastatin Pharmacokinetics: A Systematic Review and Meta-Analysis.

Although several studies have revealed the association between rosuvastatin pharmacokinetics and the ABCG2 421C>A (rs2231142) polymorphism, most studies were conducted with small sample sizes, making it challenging to apply the findings clinically. Therefore, the purpose of this study is to perform a meta-analysis of the relationship between the ABCG2 421C>A polymorphism and rosuvastatin pharmacokinetics. We searched three electronic databases, EMBASE, PubMed, and Web of Science, using search terms related to ABCG2 gene polymorphisms and rosuvastatin.

Association of P450 Oxidoreductase Gene Polymorphism with Tacrolimus Pharmacokinetics in Renal Transplant Recipients: A Systematic Review and Meta-Analysis.

There are conflicting results regarding the effect of the P450 oxidoreductase () genotype on the tacrolimus (TAC) pharmacokinetics (PKs) during the early post-transplantation period in adult renal transplant recipients. Thus, we characterized the impact of on TAC PKs. We conducted a systematic review on the association between and PKs of TAC in adult renal transplant recipients.

Genetic Factors of Renin-Angiotensin System Associated with Major Bleeding for Patients Treated with Direct Oral Anticoagulants.

The purpose of this study was to identify the renin-angiotensin system (RAS)-related genetic factors associated with bleeding and develop the bleeding risk scoring system in patients receiving direct oral anticoagulants (DOACs). This study was a retrospective analysis of prospectively collected samples from June 2018 to May 2020. To investigate the associations between RAS-related genetic factors and major bleeding, we selected 16 single nucleotide polymorphisms (SNPs) from five genes (namely, , , , , and ).

Effects of Ephedrine-Containing Products on Weight Loss and Lipid Profiles: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Ephedrine, the main active ingredient of mahuang, may lead to weight loss; however, it can also induce cardiovascular side effects. As ephedrine use remains controversial, this study aimed to systematically review previous studies on ephedrine-containing products and perform meta-analysis of the existing evidence on weight, blood pressure (BP), heart rate, and lipid change effects of ephedrine-containing products. We searched for placebo-controlled randomized studies in PubMed, Web of Science, and EMBASE until July 2021 using the following search terms: (ephedr* OR mahuang) AND ("weight loss" OR obes* OR overweight).

Association between Gene Polymorphisms and Ritodrine Treatment Outcomes in Patients with Preterm Labor.

The purpose of this study was to investigate the genetic effects of on ritodrine responses in patients with preterm labor. Five single nucleotide polymorphisms (SNPs) of the gene in 163 patients in preterm labor were genotyped: rs879619, rs2601796, rs2531988, rs2531995, and rs2230739. Additionally, rs598961 of the gene and rs1042719 of the gene were included for analysis.

Association between Gene Polymorphisms and Plasma Lipid Concentration: A Systematic Review and Meta-Analysis.

Background: Although gene polymorphisms may be associated with the plasma lipid concentration, the literature has not shown a consistent pattern. In this study, we attempted to elucidate the association between the 69C>T, 825V>I, and 230R>C polymorphisms and the plasma lipid concentration through a systematic review and meta-analysis.

Methods: We selected studies published up to October 2020 in the PubMed, Web of Science, and Embase databases according to inclusion and exclusion criteria.

Association between Polymorphism and Statin-Induced Adverse Events: A Systemic Review and Meta-Analysis.

Cytochrome P450 (CYP) is involved in the metabolism of statins; CYP3A5 is the main enzyme responsible for lipophilic statin metabolism. However, the evidence of the association between polymorphism and the risk of statin-induced adverse events remains unclear. Therefore, this study aimed to perform a systematic review and meta-analysis to investigate the relationship between the polymorphism and the risk of statin-induced adverse events.

Influence of Genetic Polymorphisms on the Pharmacokinetics of Losartan and Its Active Metabolite E-3174: A Systematic Review and Meta-Analysis.

This study aimed to investigate the influence of genetic polymorphisms on the pharmacokinetics of losartan and its active metabolite, E-3174, through a systematic review and meta-analysis. Eight studies published before March 2021 were included in this study. We used PubMed, the Cochrane Library, EMBASE, and Web of Science, based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.

Self-assembly of fluorescent and magnetic Fe3O4@coordination polymer nanochains.

Fluorescent and magnetic Fe3O4@coordination polymer (Fe3O4@CP) nanochains are synthesized via a simple one-pot solvothermal reaction of magnetite (Fe3O4) and coordination polymer precursors in the presence of an external magnetic field. The shell thickness within Fe3O4@CPs was easily regulated by varying the amounts of coordination polymer precursors used during the reaction.

Synthesis, microstructure, and magnetic properties of monosized MnxZnyFe3 - x - yO4 ferrite nanocrystals.

We report the synthesis and characterization of ferrite nanocrystals which exhibit high crystallinity and narrow size distributions. The three types of samples including Zn ferrite, Mn ferrite, and Mn-Zn ferrite were prepared via a non-aqueous nanoemulsion method. The structural, chemical, and magnetic properties of the nanocrystals are analyzed by transmission electron microscopy, X-ray diffraction, X-ray fluorescence, and physical property measurement system.

A new function of Skp1 in the mitotic exit of budding yeast Saccharomyces cerevisiae.

We previously reported that Skp1, a component of the Skp1-Cullin-F-box protein (SCF) complex essential for the timely degradation of cell cycle proteins by ubiquitination, physically interacts with Bfa1, which is a key negative regulator of the mitotic exit network (MEN) in response to diverse checkpoint-activating stresses in budding yeast. In this study, we initially investigated whether the interaction of Skp1 and Bfa1 is involved in the regulation of the Bfa1 protein level during the cell cycle, especially by mediating its degradation. However, the profile of the Bfa1 protein did not change during the cell cycle in skp1-11, which is a SKP1 mutant allele in which the function of Skp1 as a part of SCF is completely impaired, thus indicating that Skp1 does not affect the degradation of Bfa1.