Prostaglandins are implicated in the labor process, yet the precise role and regulation of the prostaglandin pathway remains to be elucidated. The first step in the pathway is cleavage of membrane phospholipids by phospholipase A (PLA). Previous work demonstrated upregulation of secretory PLA (sPLA)-IIA with labor in human myometrium, and recent evidence shows that there are numerous PLA isoforms.
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