Publications by authors named "Hayley Moulding"
Background: Caring for children with pathogenic neurodevelopmental Copy Number Variants (CNVs) (ie, deletions and duplications of genetic material) can place a considerable burden on parents and their quality of life. Our study is the first to examine the frequency of psychiatric diagnoses in mothers of children with CNVs compared with the frequency of psychiatric problems in age-matched mothers from a large community study.
Methods: Case-control study.
Article Synopsis
- Young people with 22q11.2 Deletion Syndrome (22q11.2DS) are at a higher risk for various mental health conditions, including schizophrenia and ADHD, and also experience sleep problems, prompting this study to explore how sleep might reflect neural disruptions linked to these conditions.
- The research involved analyzing sleep patterns and brain activity through high-density EEG in 28 individuals with 22q11.2DS and 17 unaffected siblings, revealing significant differences in sleep architecture and EEG characteristics between the two groups.
- Findings indicated that altered sleep EEG in 22q11.2DS was associated with psychiatric symptoms and may indicate disrupted neurodevelopment, suggesting that these sleep patterns could serve as indicators for understanding underlying neurobiological
The repair of DNA double strand breaks is essential for cell survival and several conserved pathways have evolved to ensure their rapid and efficient repair. The non-homologous end joining pathway is initiated when Ku binds to the DNA break site. Ku is an abundant nuclear heterodimer of Ku70 and Ku80 with a toroidal structure that allows the protein to slide over the broken DNA end and bind with high affinity.
View Article and Find Full Text PDFIn dementia with Lewy bodies (DLB), blood flow tends to be reduced in the occipital cortex. We previously showed elevated activity of the endothelin and angiotensin pathways in Alzheimer's disease (AD). We have measured endothelin-1 (ET-1) level and angiotensin-converting enzyme (ACE) activity in the occipital cortex in DLB and control brains.
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