Right upper quadrant (RUQ) abdominal pain and discomfort is a common presenting complaint often associated with abdominal pathology. We report a rare presentation of structural intracranial pathology in a patient initially presenting with RUQ abdominal discomfort. While initial investigations concentrating on abdominal causes revealed no likely culprit, progression of symptoms to involve right lower limb weakness eventually prompted the patient's re-presentation and eventual definitive diagnosis.
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