Approaches for Targeting Using Nanoparticles and Artificial Peptides.

is a free-living amoeba which causes primary amoebic meningoencephalitis (PAM). Although PAM is rare, the fatality rate is staggering at over 97%. So, the importance of finding an effective treatment and cure for PAM caused by is a crucial area of research.

High-Throughput Screen of Microbial Metabolites Identifies FF ATP Synthase Inhibitors as New Leads for Infection.

Primary amebic meningoencephalitis (PAM), a brain infection caused by a free-living ameba , leads to an extensive inflammation of the brain and death within 1-18 (median 5) days after symptoms begin. Although natural products have played a significant role in the development of drugs for over a century, research focusing on identifying new natural product-based anti- agents is limited. We undertook a large-scale ATP bioluminescence-based screen of about 10,000 unique marine microbial metabolite mixtures against the trophozoites of .