Cross-species evidence for a developmental origin of adult hypersomnia with loss of synaptic adhesion molecules .

Idiopathic hypersomnia (IH) is a poorly-understood sleep disorder characterized by excessive daytime sleepiness despite normal nighttime sleep. Combining human genomics with behavioral and mechanistic studies in fish and flies, we uncover a role for , synaptic adhesion molecules of the immunoglobulin superfamily, in excessive sleepiness. Neuronal knockdown of Drosophila results in sleepy flies and loss of the vertebrate ortholog of , , results in sleepy fish.