Publications by authors named "Hayford M Howard"
Article Synopsis
- The study examined the safety and effectiveness of moxidectin versus ivermectin in treating Onchocerca volvulus infections, particularly focusing on microfilariae levels and ocular adverse reactions in patients with high microfilarial counts.
- Data were collected from 1,463 participants, and results showed that both treatments had similar impacts on ocular microfilariae levels (mfAC) and resulted in Mazzotti reactions in about 10-12% of participants, with factors like gender and pre-treatment mfAC influencing the severity of reactions.
- The findings suggest that while both treatments are effective, women and those with higher mfAC levels may be at increased risk for more severe ocular reactions post
Background: Our study in CDTI-naïve areas in Nord Kivu and Ituri (Democratic Republic of the Congo, DRC), Lofa County (Liberia) and Nkwanta district (Ghana) showed that a single 8 mg moxidectin dose reduced skin microfilariae density (microfilariae/mg skin, SmfD) better and for longer than a single 150μg/kg ivermectin dose. We now analysed efficacy by study area and pre-treatment SmfD (intensity of infection, IoI).
Methodology/principal Findings: Four and three IoI categories were defined for across-study and by-study area analyses, respectively.