Climbing the Hydrogen Evolution Volcano with a NiTi Shape Memory Alloy.

Alkaline water electrolysis is a sustainable way to produce green hydrogen using renewable electricity. Even though the rates of the cathodic hydrogen evolution reaction (HER) are 2-3 orders of magnitude less under alkaline conditions than under acidic conditions, the possibility of using non-precious metal catalysts makes alkaline HER appealing. We identify a novel and facile route for substantially improving HER performance via the use of commercially available NiTi shape memory alloys, which upon heating undergo a phase transformation from the monoclinic martensite to the cubic austenite structure.

An Innovative Approach to Calcaneal Decubitus Ulcerations Through Calcaneal Decorticalization with Use of Localized Bone Marrow and Negative-Pressure Wound Therapy: A Case Study.

Heel decubitus ulcerations are relatively common occurrences that can be limb threatening. There are many options to treat these ulcerations, ranging from conservative wound care to serial debridement with flap reconstruction. However, not all patients are good candidates for major reconstructive surgery.

Exploring Mental Health and Illness in the UK Sports Coaching Workforce.

There is growing international concern about the mental health of those who work in sport, including coaches. However, we currently know little about the prevalence of mental illness and the experience of mental health among coaches, and their perceptions and use of workplace mental health support services. Little is also known about coaches' disclosure of mental illness to, and seeking help from, work colleagues.

Arthroscopy-assisted retrograde drilling of osteochondral lesions of the talar dome.

Traumatic ankle conditions can lead to long-term sequelae if a pathologic process is misdiagnosed. The clinical presentation of an osteochondral lesion of the talar dome requires the clinician to have a high index of suspicion, and advanced imaging is often necessary to make the final diagnosis. Treatment should be initiated once the lesion is appropriately staged by radiologic or magnetic resonance imaging.

Flexible flatfoot treatment with arthroereisis: radiographic improvement and child health survey analysis.

This study was designed to ascertain if there was a statistically significant correction in the foot and to determine the overall health of a child after an arthroereisis procedure. Thirty-seven patients (67 feet) who had undergone Maxwell-Brancheau arthroereisis were retrospectively reviewed at an average of 18.4 months after surgery.

Coleridge's choleras: cholera morbus, Asiatic cholera, and dysentery in early nineteenth-century England.

Samuel Taylor Coleridge suffered from a variety of bowel disorders throughout his life; though a large part of his ailment was caused by his famous opium habit, he continuously sought an organic origin, and on at least two separate occasions, in 1804 and 1831-32, he ascribed his disorders to attacks of "cholera." With Asiatic cholera apparently first reaching England in late 1831, there was considerable argument among both physicians and the general public as to whether it was a distinctly new disease, or merely a severer variation of traditional English cholera, known as "cholera morbus." Coleridge took a particular interest in these discussions.

Mesoscopic quantum coherence in an optical lattice.

We observe the quantum coherent dynamics of atomic spinor wave packets in the double-well potentials of a far-off-resonance optical lattice. With appropriate initial conditions the system Rabi oscillates between the left and right localized states of the ground doublet, and at certain times the wave packet corresponds to a coherent superposition of these mesoscopically distinct quantum states. The atom/optical double-well potential is a flexible and powerful system for further study of quantum coherence, quantum control, and the quantum/classical transition.

Rapid MRI and velocimetry of cylindrical Couette flow.

A narrow-gap, temperature-controlled Couette flow rheometer has been developed to study fluid velocities within the annular gap between two concentric cylinders by nuclear magnetic resonance (NMR) imaging and velocimetry. Alternative pulsed-field-gradient-based nuclear magnetic resonance imaging strategies which may be used for measurement of velocity within the Couette flow device have been evaluated. These include two-dimensional (2-D) imaging techniques with acquisition times of several minutes and a one-dimensional (1-D) projection method which exploits the symmetry of the device to reduce overall measurement time to less than 1 min.

Strategies for Rapid NMR Rheometry by Magnetic Resonance Imaging Velocimetry.

Strategies for NMR-based rheometry are discussed with particular attention given to ease of implementation, robustness, and measurement speed. The techniques are based on NMR velocimetry of Poiseuille flow, and together with measurements of the pressure drop, the velocimetric data may be processed to yield measures of the shear viscosity over the range of shear rates present in the Poiseuille flow field of the test fluid. Methods for NMR velocimetry are briefly reviewed, and three methods all based on the pulsed-field-gradient technique are compared experimentally; they involve (1) direct two-dimensional imaging of the tube cross section, (2) one-dimensional imaging of a Cartesian projection of the tube cross section followed by Abel inversion to obtain radial profiles, and (3) measurement of the bulk velocity spectrum of the tube cross section and conversion to the radial velocity profile.

WIN 64821, a novel neurokinin antagonist produced by an Aspergillus sp. II. Biological activity.

WIN 64821, a secondary metabolite produced by Aspergillus sp. (ATCC 74177) was found to inhibit radiolabeled substance P (SP) binding in a variety of tissues, including those of human origin. This compound inhibited, in a competitive manner, the binding of SP with Ki values ranging from 0.

Aminoalkylindole binding in rat cerebellum: selective displacement by natural and synthetic cannabinoids.

A binding assay for WIN 55212-2, an aminoalkylindole (AAI) with antinociceptive activity in rodents, is described. [3H]WIN 55212-2 bound to rat cerebellar membranes with a Kd of 2 nM and a maximum binding of 1.2 pmol/mg of protein.

Characterization of bradykinin B2 receptors on human IMR-90 lung fibroblasts: stimulation of 45Ca2+ efflux by D-Phe substituted bradykinin analogues.

[3H]Bradykinin binds to intact human IMR-90 fetal lung fibroblasts in a time and dose-dependent manner. Binding equilibrium was attained by 120 minutes at 4 degrees C. [3H]Bradykinin binding was saturable; Scatchard analysis of saturation binding data demonstrated a single binding site having a KD = 1.

Distribution of cannabinoid receptors in rat brain determined with aminoalkylindoles.

Extensive mapping of the cannabinoid receptor in rat brain has been reported recently using synthetic cannabinoids. Another class of compounds, the aminoalkylindoles (AAIs), does not resemble the cannabinoids structurally. Ligand binding data on isolated membranes, however, indicate that AAIs bind to the cannabinoid receptor.

Conformationally restrained analogues of pravadoline: nanomolar potent, enantioselective, (aminoalkyl)indole agonists of the cannabinoid receptor.

Pravadoline (1) is an (aminoalkyl)indole analgesic agent which is an inhibitor of cyclooxygenase and, in contrast to other NSAIDs, inhibits neuronally stimulated contractions in mouse vas deferens (MVD) preparations (IC50 = 0.45 microM). A number of conformationally restrained heterocyclic analogues of pravadoline were synthesized in which the morpholinoethyl side chain was tethered to the indole nucleus.

Tyrosine hydroxylase in rat brain dopaminergic nerve terminals. Multiple-site phosphorylation in vivo and in synaptosomes.

Tyrosine hydroxylase, which catalyzes the initial step in catecholamine biosynthesis, is phosphorylated at serines 8, 19, 31, and 40 in intact pheochromocytoma (PC12) cells (Haycock, J.W. (1990) J.

A comparison of the new topical antibiotic mupirocin ('Bactroban') with oral antibiotics in the treatment of skin infections in general practice.

A trial was carried out in general practice in 200 patients presenting with skin infections to compare topical antibiotic treatment with mupirocin ointment with orally administered flucloxacillin or erythromycin. Patients were assigned at random to receive 4 to 10 days' treatment with either mupirocin applied 3-times daily or one of the oral antibiotics in the dosage normally used by the general practitioner for skin infections. The majority of infections were impetigo and infected wounds/lacerations; the main organisms isolated initially from 127 of the patients were either Staphylococcus aureus or beta-haemolytic Group A streptococci.