Publications by authors named "Hayato Aoki"
Background: The presence of medial tibial osteophytes on knee radiographs suggests cartilage wear, but may be associated with medial meniscus extrusion (MME). The joint space width of the medial compartment consists anatomically of cartilage and the medial meniscus, but which is most responsible for joint space narrowing remains unclear. Magnetic resonance imaging (MRI) reveals MME and cartilage thickness.
View Article and Find Full Text PDFObjectives: Radiographs are the most widespread imaging tool for diagnosing osteoarthritis (OA) of the knee. Our purpose was to determine which of the two factors, medial meniscus extrusion (MME) or cartilage thickness, had a greater effect on the difference in the minimum joint space width (mJSW) at the medial compartment between the extension anteroposterior view (extension view) and the 45° flexion posteroanterior view (Rosenberg view).
Methods: The subjects were 546 participants (more than 50 females and 50 males in their 30 s, 40 s, 50 s, 60 s, and 70 s) in the Kanagawa Knee Study.
Background: We developed a fully automatic three-dimensional knee MRI analysis software that can quantify meniscus extrusion and cartilage measurements, including the projected cartilage area ratio (PCAR), which represents the ratio of the subject's actual cartilage area to their ideal cartilage area. We also collected 3D MRI knee data from 561 volunteers (aged 30-79 years) from the "Kanagawa Knee Study." Our purposes were to verify the accuracy of the software for automatic cartilage and meniscus segmentation using knee MRI and to examine the relationship between medial meniscus extrusion measurements and cartilage measurements from Kanagawa Knee Study data.
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- Researchers analyzed a library of dipeptides for their effects on ghrelin, a hormone that regulates hunger, using a specific cell line.
- Most dipeptides were found to suppress ghrelin secretion, but some, particularly those containing serine at the N-terminal, stimulated it, with Leu-Ile (LI) and Ser-Val (SV) showing the most significant effects.
- When administered to mice, LI decreased plasma ghrelin levels and food intake, while SV increased them, highlighting their potential roles in appetite regulation.
Ghrelin, an endogenous peptide isolated from the stomach, is known to stimulate food intake after peripheral administration. We found that the enzymatic digest of β-lactoglobulin decreases ghrelin secretion from the ghrelin-producing cell line MGN3-1. The peptides present in the digest were comprehensively analyzed using the nanoLC-OrbitrapMS.
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- Recent studies highlight the potential benefits of preoperative endoscopic ultrasonography-guided fiducial tattooing (EUS-tattooing) for pancreas tumor marking, though procedural challenges remain unresolved.
- This study analyzed six patients who underwent EUS-tattooing using a new injector to deliver a very small amount (0.02 mL) of a marking solution, a mix of sodium hyaluronate and India ink.
- Results showed that the tattoo mark could be successfully detected in five out of six patients during surgery, with no significant adverse events reported, indicating that EUS-tattooing may be safe and effective, but further research is needed.
We investigated exogenous secretagogues of ghrelin, which is an orexigenic hormone isolated from the stomach. We found that the tryptic digest of soy β-conglycinin stimulated ghrelin secretion by the ghrelin-producing cell line, MGN3-1. We then identified a 22-amino acid peptide corresponding to the β-conglycinin α-subunit(192-213) [βCGα(192-213)] from an active fraction separated by HPLC.
View Article and Find Full Text PDFA Rare Cause of Hematochezia With Unique Findings on Colonoscopy.
Clin Gastroenterol Hepatol
October 2016