Laser Upcycling of Hemoglobin Protein Biowaste into Engineered Graphene Aerogel Architectures for 3D Supercapacitors.

Graphene aerogels (GAs) with engineered architectures are a promising material for applications ranging from filtration to energy storage/conversion. However, current preparation approaches involve the combination of multiple intrinsically-different methodologies to achieve graphene-synthesis and architecture-engineering, complicating the entire procedure. Here, a novel approach to prepare GAs with engineered architectures based on the laser-upcycling of protein biowaste, hemoglobin, is introduced.

High levels of REV7 expression are associated with poor prognosis and chemoresistance in gastric adenocarcinoma.

REV7 is a multifunctional protein essential for promoting cellular tolerance to DNA damage. REV7 expression is associated with disease progression and prognosis in several human malignant tumors. This study aimed to evaluate the clinical and biological significance of REV7 in gastric adenocarcinoma (GAD).

Potential role of electroencephalographic monitoring for diagnosis and treatment of local anesthetic systemic toxicity during general anesthesia: a case report.

Background: Local anesthetic systemic toxicity (LAST) is a rare but potentially life-threatening complication. Under general anesthesia, neurological signs are often masked, delaying diagnosis and increasing the risk of sudden cardiovascular collapse. Therefore, early detection methods are critically needed.

Cyclosporine A Causes Gingival Overgrowth by Promoting Entry into the S Phase at the G1/S Cell Cycle Checkpoint in Gingival Fibroblasts Exposed to Lipopolysaccharide.

Objectives: Cyclosporine A promotes gingival fibrosis by enhancing the proliferation of gingival fibroblasts, leading to gingival overgrowth. The population of gingival fibroblasts is regulated by cell cycle machinery, which balances cell growth and inhibition. Cells that detect DNA damage pause at the G1/S checkpoint to repair the damage instead of progressing to the S phase.

Elevated expression of REV7 correlates with poor prognosis in lung adenocarcinoma and its inactivation in carcinoma cells enhances chemosensitivity.

REV7 is a multifunctional protein involved in the DNA damage response, cell cycle regulation, gene expression, or primordial germ cell maintenance. REV7 expression in tumor cells is associated with clinical aggressive features and chemoresistance in several human malignancies, however, the clinicopathological significance of REV7 in lung adenocarcinoma (LUAD) has not been studied yet. In this study, we investigated the significance of REV7 expression in LUAD using clinical materials and cell lines.

Impact of femoral stem alignment on periprosthetic bone density in THA: a study of the Avenir Complete stem.

Introduction: Thigh pain, aseptic loosening, and failure after total hip arthroplasty has been reported. Therefore, this study examines the impact of femoral stem alignment on periprosthetic bone mineral density (BMD) in THA using the Avenir Complete cementless stem, focusing on the role of precise stem alignment in maintaining proximal femoral BMD.

Materials And Methods: Consecutive patients who received the Avenir Complete stem via mini anterolateral approach in the supine position between March 2019 and March 2022 were included.

is a potential therapeutic target for osteosarcoma: and evaluations using generated artificial osteosarcoma cancer stem cell‑like cells.

Cancer stem cells (CSCs) have been implicated as critical mediators in the progression, chemoresistance and metastatic capabilities of diverse malignancies, including osteosarcoma (OS). The authors have succeeded in generating CSC‑like cells (MG‑OKS) from the OS cell line MG‑63 by transducing defined factors. A significant increase in small proline‑rich protein 1A (SPRR1A) expression, a cross‑linked envelope protein in keratinocytes, was observed in MG‑OKS cells.

[Association between health checkups, vaccination, and social isolation among people on public assistance: The case of Izumi Public Health and Welfare Center, Sendai City].

Objective　The healthcare management support program for public assistance recipients has been mandated at all welfare centers since 2021 because the importance of healthcare support for them has recently been recognized in Japan. However, the factors that hinder preventive healthcare service utilization have not been empirically investigated. This survey aimed to identify the relationship between health checkups, vaccination services, and social isolation among people on public assistance.

Delayed development of the inferior mesenteric vein in human fetuses.

Background: The superior mesenteric vein appears as a fusion between irregularly-shaped slits of the midgut mesentery tissue at 5-6 weeks. In contrast, there might be no report when and how the inferior mesenteric vein (IMV) develops. We aimed to find the human initial IMV.

Simultaneous bilateral total hip arthroplasty results in smaller Leg length discrepancy than staged bilateral procedures.

Introduction: The purpose of this study was to compare leg length discrepancies (LLD) between simultaneous and staged bilateral total hip arthroplasty (BTHA).

Materials And Methods: This retrospective cohort study included 150 consecutive patients who underwent BTHA (60 simultaneous and 90 staged BTHA). To adjust for preoperative patient characteristics between groups, 1:1 propensity score matching was performed based on age, sex, body mass index, American Society of Anesthesiologists Physical Status, Tönnis classification, Crowe classification, preoperative range of motion (flexion and abduction), LLD, and Harris Hip Score (HHS).

Identification of C-mannosylation in a receptor tyrosine kinase AXL.

C-mannosylation is a unique type of glycosylation in which a mannose is added to tryptophan in a protein. However, the biological function of C-mannosylation is still largely unknown. AXL is a receptor tyrosine kinase, and its overexpression contributes to tumor malignancy.

Ligand-Functionalized Organometallic Polyoxometalate as an Efficient Catalyst Precursor for Amide Hydrogenation.

Amide hydrogenation is an important process for producing amines, with the development of efficient heterogeneous catalysts relying on the creation of bimetallic active sites where the two components interact synergistically. In this study, we develop a method for preparing catalysts using ligand-functionalized organometallic polyoxometalates by synthesizing a Rh-Mo organometallic polyoxometalate, [(RhCp)MoO] (Cp = C(CH)(COOCH)), with Rh-O-Mo interfacial structures and ethoxycarbonyl-functionalized ligands as a catalyst precursor. The activity of supported Rh-Mo catalysts for amide hydrogenation depend on the precursor used, with [(RhCp)MoO] showing the highest activity, followed by [(RhCp*)MoO] (Cp* = C(CH)), and then RhCl combined with (NH)[MoO]·4HO.

Usefulness of Apple Watch Electrocardiograms for Identifying the Origin of Premature Ventricular Contractions.

Background: The Apple Watch (AW) can record single-lead electrocardiograms (ECGs) and has been investigated for arrhythmia detection. In this study we evaluated its accuracy in identifying the origin of premature ventricular contractions (PVCs) vs. standard 12-lead ECGs.

Indigenous gut microbiota constitutively drive release of ciliary neurotrophic factor from mucosal enteric glia to maintain the homeostasis of enteric neural circuits.

It has recently become clear that the gut microbiota influence intestinal motility, intestinal barrier function, and mucosal immune function; therefore, the gut microbiota are deeply involved in the maintenance of intestinal homeostasis. The effects of the gut microbiota on the enteric nervous system (ENS) in the adult intestine, however, remain poorly understood. In the current study, we investigated the effects of the gut microbiota on the ENS.

Preferential Neurogenesis of Nitrergic Neurons in the Myenteric Plexus of the DSS-induced Colitis Mouse Colon Causes Colonic Dysmotility in Colitis.

Unlabelled: The enteric nervous system (ENS) continues to be exposed to various disturbances throughout life, which causes apoptosis in the ENS. Therefore, it is assumed that neurogenesis is induced to maintain the neuronal network in the adult ENS. However, these underlying mechanisms are largely unknown.

A comprehensive data network for data-driven study of battery materials.

Data-driven material research for property prediction and material design using machine learning methods requires a large quantity, wide variety, and high-quality materials data. For battery materials, which are commonly polycrystalline, ceramics, and composites, multiscale data on substances, materials, and batteries are required. In this work, we develop a data network composed of three interlinked databases, from which we can obtain comprehensive data on substances such as crystal structures and electronic structures, data on materials such as chemical composition, structure, and properties, and data on batteries such as battery composition, operation conditions, and capacity.

Mutations in Mig6 reduce inhibition of the epidermal growth factor receptor.

Mitogen-inducible gene 6 (Mig6) is a cellular inhibitor of epidermal growth factor receptor (EGFR) that binds directly to the EGFR kinase domain and interferes with signaling. Reduced Mig6 expression is correlated with increased EGFR activity in multiple cancer models. Here, we investigated whether disease-associated point mutations could reduce the inhibitory potency of Mig6.

Closure of gastric mucosal defects using the reopenable-clip over the line method to decrease the risk of bleeding after endoscopic submucosal dissection: a multicenter propensity score-matched case-control study (with video).

Background And Aims: Endoscopic submucosal dissection (ESD) is a minimally invasive treatment for early gastric cancer. However, post-ESD bleeding presents significant risks. Closing mucosal defects following ESD may reduce the incidence of post-ESD bleeding.

Classification of life satisfaction by occupational gaps and its characteristics among older adults with care needs.

Objective: Occupational therapy aims at enhancing people's life satisfaction, it is important to focus on the occupational gap between "what they want to do" and "what they actually do." This study aimed to describe the characteristics of occupational gap of older adults with care needs who are residing at home, and clarify how the occupational gap patterns classify their life satisfaction.

Method: The Occupational Gap Questionnaire was used to assess the occupational gaps of 209 older adults with care needs (80.

Limited uptake of [C]Gardenia Blue administered orally in male and female rats and mice.

Gardenia blue (GB), a widely used plant-derived food color is prepared by reaction of genipin, the aglycone of geniposide, with protein hydrolysate. Recent animal studies investigating GB toxicity have indicated blue coloration in the gastrointestinal tract, kidneys and mesenteric lymph nodes in rodents following dietary administration. This study investigated the uptake and disposition of [C]GB in male and female rats and mice administered 100 or 1000 mg/kg by gavage.

Pleural recurrence 21 years after complete resection of thymic mucoepidermoid carcinoma: a case report.

Background: Thymic mucoepidermoid carcinomas (MECs) are extremely rare malignant neoplasms. We describe a rare case of a MEC with a high histological grade in a patient who survived for more than 20 years after the initial surgery, focusing on the clinical course and recurrence pattern.

Case Presentation: A woman underwent surgical resection of a high-grade thymic MEC at another hospital 21 years ago.