Predictive utility of nomogram based on serum glucose-regulated protein 78 and kidney function for long-term kidney graft survival.

The estimated glomerular filtration rate (eGFR) at 1 year post-transplantation is a well-established predictor of long-term graft survival; however, its predictive accuracy needs improvement. We retrospectively analyzed data from 51 kidney transplant recipients at Kanazawa Medical University Hospital (January 2001-February 2015). Cox regression was used to identify risk factors for death-censored graft loss and create a nomogram to predict graft survival at 15 years post-transplantation.

Autopsy findings in a rare case of pleomorphic carcinoma in a patient on dialysis.

Pleomorphic lung cancer is a very rare type of cancer and very few cases have been reported in the literature. We present a case of pleomorphic lung cancer in a patient with history of IgA nephropathy on hemodialysis.

Nephrotic syndrome with rectus sheath hematoma: a case report.

Background: Rectus sheath hematoma is a rare presentation often associated with abdominal trauma and anticoagulant therapy. Here, we present a patient with severe rectus sheath hematoma accompanied by nephrotic syndrome who achieved significant clinical improvement without the need for invasive treatment.

Case Presentation: A 72-year-old Japanese woman was referred to our hospital for the treatment of nephrotic syndrome.

A Case of Spontaneous Remission of Membranous Nephropathy After the Removal of Nerve Epidermal Growth Factor-Like 1 Positive Sigmoid Colon Carcinoma.

Recently, the association between membranous nephropathy (MN) and malignancy has been recognized in about 30% of epidermal growth factor-like 1 (NELL-1) positive cases. However, the mechanism of association with MN and malignancy remains under search. In this report, we present a unique case of MN with positive staining for both thrombospondin type-1 domain-containing 7A (THSD7A) and NELL-1.

Case report of systemic sclerosis: Uncommon manifestation of nephrotic syndrome post-renal crisis.

Kidney involvement in systemic sclerosis occurs in about 20% of cases, with scleroderma renal crisis as a significant complication. However, cases of glomerular disease with massive proteinuria are rare. We present a unique case of systemic sclerosis with the development of nephrotic syndrome.

Early, Noninvasive Clinical Indicators of Kidney Prognosis in Primary Nephrotic Syndrome: A Retrospective Exploratory Study.

This retrospective exploratory study aimed to identify early clinical indicators of kidney prognosis in primary nephrotic syndrome (NS). Univariate Cox proportional hazards regression analysis identified clinical parameters in the 2-month period after initiating immunosuppressive therapy (IST); it predicted 40% reduction in the estimated glomerular filtration rate (eGFR) in 36 patients with primary NS. Time-dependent receiver operating characteristic curve analysis was used to evaluate the performance of the predictors for the cumulative incidence of 40% reduction in the eGFR up to 8 years after initiating IST.

Molecular Characterization of Membranous Nephropathy.

Background: Molecular characterization of nephropathies may facilitate pathophysiologic insight, development of targeted therapeutics, and transcriptome-based disease classification. Although membranous nephropathy (MN) is a common cause of adult-onset nephrotic syndrome, the molecular pathways of kidney damage in MN require further definition.

Methods: We applied a machine-learning framework to predict diagnosis on the basis of gene expression from the microdissected kidney tissue of participants in the Nephrotic Syndrome Study Network (NEPTUNE) cohort.

Association between anti-complement factor H antibodies and renal outcome in primary membranous nephropathy.

Aims: The complement factor H (CFH) is a regulator for the alternative complement pathway. The prevalence and roles of anti-CFH antibodies in the clinical outcome of primary membranous nephropathy (MN) patients remain unclear.

Materials And Methods: A total of 106 biopsy-proven kidney disease patients and 18 healthy controls were retrospectively investigated in this study.

Steroid-sensitive recurrent mesangial proliferative glomerulonephritis with monoclonal IgG deposits.

Proliferative glomerulonephritis with monoclonal immunoglobulin G (IgG) deposits (PGNMID) is a rare kidney disease. The predominant pathological finding of PGNMID is the presence of monoclonal Ig deposits on the glomerular basement membrane (GBM). However, there is some variation in deposition pattern in this kidney disease.

Moore's law for membranous nephropathy.

The identification of target antigens in membranous nephropathy has accelerated since the report of M-type phospholipase A2 receptor 1 (PLA2R1). One could say that technological advances have allowed for the demonstration of Moore's law (a doubling every 2 years in the number of transistors that can be fit onto a computer chip) in the field of membranous nephropathy, and that even more antigens can be expected in the near future. In this issue of Kidney International, Sethi et al.

Circulating CTRP9 correlates with the prevention of aortic calcification in renal allograft recipients.

Background: Cardiovascular disease (CVD) due to atherosclerosis is a major cause of death in renal allograft recipients. Recently, C1q/TNF-α related protein-9 (CTRP9), which is a paralog of adiponectin (ADPN), has been suggested to be related to the prevention of atherosclerosis and the occurrence of CVD, but this relationship has not been confirmed in renal allograft recipients.

Subjects And Methods: The relationships among the serum CTRP9 concentration, serum ADPN concentration, and vascular calcification were investigated in 50 kidney transplantation recipients at our hospital.

Changes in double-strand DNA breaks predict delayed graft function (DGF) in Japanese renal allograft recipients.

Background: Although delayed graft function (DGF) is a serious complication following kidney transplantation, a reliable and early diagnostic test is lacking to identify the grade of DGF.

Methods: We investigated changes in double-strand DNA breaks (DSBs), and factors related to DGF, such as ischemic times at transplantation and serum creatinine (sCr) levels. DSBs were detected by phospho-histone H2A.

High molecular weight adiponectin inhibits vascular calcification in renal allograft recipients.

Background: Adiponectin (ADPN) prevents the development/recurrence of cardiovascular events via its anti-atherogenic effects. However, few long-term studies have examined the changes in serum ADPN levels and arterial calcification seen in renal allograft recipients.

Subjects And Methods: The effects of the serum ADPN level on arterial calcification were examined in 51 Japanese renal allograft recipients.

Glomerular mannose-binding lectin deposition in intrinsic antigen-related membranous nephropathy.

Background: The M-type phospholipase A2 receptor (PLA2R) and thrombospondin type-1 domain-containing 7A (THSD7A) were identified as intrinsic antigens in primary membranous nephropathy (MN). Complement activation via the lectin pathway in intrinsic antigen-related MN is still unclear.

Methods: We retrospectively enrolled 60 primary Japanese MN patients and detected activated complement pathways by staining complement proteins in glomerular deposition.

Circulating and renal expression of HLA-G prevented chronic renal allograft dysfunction in Japanese recipients.

Background: Although the risk of acute rejection has been studied in renal transplanted patients, there is little data about the long-term renal survival effects of non-classical human leukocyte antigen class I (HLA-G) in Japanese patients.

Method: We investigated the changes in the estimated glomerular filtration rate (eGFR) for Japanese, and factors affecting the eGFR in 141 adult Japanese subjects whose allografts had survived for at least 1 year. Clinical background data, gender, HLA matching status, the total ischemic time, ABO incompatibility, immunosuppressive therapy, and the serum soluble(s) HLA-G5 level were examined.

The long-term outcomes of hepatitis C virus core antigen-positive Japanese renal allograft recipients.

Background: The impact of hepatitis C virus (HCV) infections on patient long-term survival after renal transplants is unclear.

Method: To clarify the long-term outcomes of Japanese renal allograft recipients with HCV infections, we studied the cases of 187 patients (118 males and 69 females; 155 living donor cases, and 32 deceased donor cases; median follow-up period: 250 months) who underwent an initial renal transplant at Kanazawa Medical University from 1974 onwards.

Result: In this cohort, 35 patients (18.

Adiponectin Fractions Influence the Development of Posttransplant Diabetes Mellitus and Cardiovascular Disease in Japanese Renal Transplant Recipients.

Background: A few studies have investigated the role of adiponectin fraction for cardiovascular disease (CVD) in RTx recipients.

Subjects And Methods: We studied 57 adult subjects (39 males, 18 females; 10 cadaveric donors) with at least three years of allograft survival (median 251 months). We examined clinical backgrounds such as treated drugs, blood pressure (BP, mmHg), body mass index (BMI), and blood chemistry including cholesterol (total, LDL-C, HDL-C), glucose, glycated hemoglobin (HbA1c), and serum high and low-molecular-weight (HMW/LMW) ADPN fractions with regard to the associations of the visceral and subcutaneous fat areas on CT scan.

DNA double-strand breaks induced intractable glomerular fibrosis in renal allografts.

Backgrounds: The relationship between DNA damage and glomerular fibrosis in renal allografts remains unclear.

Methods: We examined renal allograft specimens from 35 patients in which DNA double-strand breaks (DSBs) and glomerular fibrosis were detected by phospho-histone H2A.X (γ-H2AX) expression and collagen (COL) types III, IV, and VI accumulation.

Adult-onset renal failure in a family with Alagille syndrome with proteinuria and a novel JAG1 mutation.

Alagille syndrome (AGS) is an autosomal-dominant multi-organ disorder involving the liver, heart, eyes, face and skeleton. In addition, various renal abnormalities have also been reported in several cases. We describe a patient with a novel frameshift mutation in exon 12 of the JAG1 gene who presented with chronic renal failure.

Relationship between the color of carious dentin with varying lesion activity, and bacterial detection.

Objectives: To investigate the relationship between the color of carious dentin with varying lesion activity, and bacterial detection in the lesions.

Methods: In 26 extracted human molars with coronal dentin caries and four extracted sound human molars, dentin was removed by a round bur every 150 microm from the dentin surface, in the direction of the pulp chamber. Before and after removal, images of nine-color samples and the dentin surface stained with a caries detector dye (1% acid red in propylene glycol) were taken simultaneously by a charge-coupled device (CCD), and dentinal tissue samples were taken with a new round bur.

Evaluating the objectivity of caries removal with a caries detector dye using color evaluation and PCR.

Objectives: This laboratory study evaluated the objectivity of caries removal with a caries detector dye by color and bacterial evaluations.

Methods: In 41 cases of dentin caries (32 extracted human molars), carious tissues were removed using a caries detector dye. Images of dentin surfaces with color-matching stickers were acquired using a CCD camera, and dentinal tissue samples were collected with new round burs.