Lipoxin-Induced Phenotypic Changes in CD115LY6C Monocytes TAM Precursors Inhibits Tumor Development.

During tumor development, the spleen acts as an extra-medullar reservoir of LY6C inflammatory monocytes, which can migrate toward tumor to differentiate into tumor-associated macrophage (TAMs), renewing the TAM population. In the tumor microenvironment, pro-inflammatory macrophages (M1) acquire anti-inflammatory and pro-tumor (M2) characteristics favoring tumor development. We previously demonstrated that lipoxins, a family of pro-resolving lipid mediators, restored the cytotoxic M1-like properties of TAMs.