Publications by authors named "Hayami Yoshizawa"
Article Synopsis
- Chemerin, an adipocytokine linked to metabolic issues like coronary artery disease (CAD), was studied alongside its receptor ChemR23 to understand their roles in atherosclerosis.* -
- In human vascular cells, chemerin and its analog chemerin-9 were shown to reduce inflammation and the formation of foam cells, which are key components of atherogenesis.* -
- In mouse models, infusion of chemerin-9 notably decreased the size of atherosclerotic lesions, suggesting that chemerin-9 could be a promising treatment for atherosclerotic diseases.*
Background: Kisspeptin-10 (KP-10), a potent vasoconstrictor and inhibitor of angiogenesis, and its receptor, GPR54, have currently received much attention in relation to pre-eclampsia. However, it still remains unknown whether KP-10 could affect atherogenesis.
Methods And Results: We evaluated the effects of KP-10 on human umbilical vein endothelial cells, human monocyte-derived macrophages, human aortic smooth muscle cells in vitro, and atherosclerotic lesions in apolipoprotein E-deficient (ApoE) mice in vivo.