Publications by authors named "Hayami Kudo"
In patients undergoing haematopoietic stem-cell transplantation (HSCT), the intestinal microbiota plays an important role in prognosis, transplant outcome, and complications such as graft-versus-host disease (GVHD). Our prior research revealed that patients undergoing HSCT substantially differed from healthy controls. In this retrospective study, we showed that administering Clostridium butyricum MIYAIRI 588 (CBM588) as a live biotherapeutic agent is associated with maintaining intestinal microbiota in the early post-HSCT period.
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- Antifungal treatments often fail to effectively resolve or prevent vulvovaginal candidiasis (VVC), a common condition caused by Candida overgrowth, despite the protective role of lactobacilli in the vaginal microbiota.
- Researchers evaluated the effects of lactobacilli metabolites on various Candida strains, discovering that these metabolites significantly inhibited fungal biofilm formation and growth to varying degrees.
- The study suggests that enhancing the healthy vaginal flora and its metabolites could lead to new, more effective antifungal therapies for managing VVC.
Tetracyclines (TCs) are widely used for livestock, and the high prevalence of TC-resistant Escherichia coli in livestock has become a serious concern worldwide. In Japan, the National Action Plan on Antimicrobial Resistance in 2016 aimed to reduce the TC resistance rate in E. coli derived from livestock.
View Article and Find Full Text PDFEndometritis has a major impact on fertility in postpartum dairy cows. Since previous studies showed an association between reproductive microbiota and perinatal disease, we monitored both bovine uterine and vaginal microbiota in primiparous cows to elucidate the effect of early postpartum microbiota on endometritis. Uterine and vaginal samples were collected at time points from pre-calving to 35 days postpartum (DPP), and analyzed by 16S rRNA sequencing, combined with ancillary bacterial culture.
View Article and Find Full Text PDFShiga toxin-producing Escherichia coli (STEC) can cause severe gastrointestinal disease and colonization among food handlers. In Japan, STEC infection is a notifiable disease, and food handlers are required to undergo routine stool examination for STEC. However, the molecular epidemiology of STEC is not entirely known.
View Article and Find Full Text PDFFlavophospholipol (FPL) is an antimicrobial feed additive that has been approved for use in livestock animals and has the potential to decrease horizontal dissemination of antimicrobial resistance genes. Since previous studies showed that FPL has an inhibitory effect on plasmid transfer, in vitro experiments have proven the efficacy of FPL in reducing the conjugative transfer of plasmids encoding the extended-spectrum β-lactamase (ESBL) and vanA genes. These are among the most important antimicrobial resistance loci known.
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- Clostridium butyricum MIYAIRI 588 (CBM 588) is a probiotic used in Japan to treat diarrhea, but its effects on gut microbiomes during antimicrobial use are not well understood.
- An in vivo study with mice involved administering different treatments, including CBM 588 alone, clindamycin alone, a combination of both, or a control solution, followed by fecal sample analysis for microbial content and metabolic activity.
- Results showed that CBM 588 did not change C. butyricum levels compared to combination therapy; however, it positively affected gut bacteria composition and increased lactic acid production, whereas clindamycin led to negative digestive tissue changes.