Publications by authors named "Hayam A Alrasheed"
Background/objectives: The prevalence of type 2 diabetes and smoking is increasing in developing countries and is associated with deteriorated health outcomes. Also, addiction to smartphone use is an alarming behavior that can be associated with clinical factors. This study aimed to determine the prevalence and clinical correlates of smartphone addiction in smokers with T2DM in Jordan, with a particular focus on the role of medications.
View Article and Find Full Text PDFBackground: Tuberculosis (TB) remains a significant health concern in India, especially among households with children and young adolescents aged 6-17 years. Despite ongoing research, there is a knowledge gap regarding specific risk factors for TB within this demographic. This study aims to bridge this gap by examining the association between TB and various socio-demographic factors, including socioeconomic status, nutritional status, and environmental conditions.
View Article and Find Full Text PDFArticle Synopsis
- The COVID-19 pandemic has had serious effects on maternal and neonatal health, prompting a systematic review to assess how it influences respiratory distress syndrome (RDS) in newborns from infected mothers.
- The review analyzed 22 studies and found that 11.5% of newborns from COVID-19-positive mothers experienced RDS, with a risk ratio of 2.69 indicating a significantly higher risk compared to newborns from non-infected mothers.
- The findings stress the importance of closely monitoring and managing pregnant women with COVID-19 to reduce potential health issues in their newborns.
Background: Malaria continues to be a critical public health concern in India, predominantly driven by complex interplays of ecological, climatic, and socioeconomic factors.
Methods: This study aimed to assess the association between climatic variables (temperature and precipitation) and malaria incidence across India from 2010 to 2019, utilizing data from the Global Historical Weather and Climate Data for climate metrics and the Global Burden of Disease Study for malaria incidence rates. Generalized Linear Mixed Models (GLMMs) with a Poisson distribution were employed to analyze the data, adjusting for socio-economic status, as indexed by the Human Development Index (HDI).
Dengue virus (DENV) remains one of the most common arboviral infections threatening humans. This study was conducted to systematically review the available literature and provide an updated overview of the overall prevalence of DENV infection in Saudi Arabia. The prevalence data was pooled from 21,891 participants recruited in 17 studies.
View Article and Find Full Text PDFDengue fever, caused by the dengue virus and transmitted through Aedes mosquitoes, is a growing public health concern, particularly in tropical and subtropical regions. Traditionally associated with febrile and hemorrhagic symptoms, recent research suggests a potential link between dengue and cognitive impairments. This systematic review assessed existing research to understand the association between dengue virus infection and cognitive impairments, including dementia, Alzheimer disease, memory loss, and confusion.
View Article and Find Full Text PDFBackground: Crohn's disease is a chronic, relapsing form of inflammatory bowel disease marked by severe gastrointestinal inflammation and a broad range of debilitating symptoms. Despite advances in medical treatments, achieving sustained remission remains challenging for many patients. This umbrella review aims to consolidate evidence from various systematic reviews to evaluate the efficacy and safety of stem cell therapies in treating Crohn's disease.
View Article and Find Full Text PDFBackground: Mpox is a severe viral zoonosis that has emerged as a public health concern due to its potential for human-to-human transmission and severe illness. Understanding its clinical manifestations is crucial for effective management and control. Several systematic reviews have assessed various manifestations of Mpox.
View Article and Find Full Text PDFBackground: Malaria in pregnancy is a critical public health issue that can lead to severe adverse outcomes for both mother and fetus. This systematic review and meta-analysis evaluated the prevalence of adverse birth outcomes in malaria-infected pregnancies and examines their association with the condition.
Method: We searched databases up to January 30, 2024, for observational studies on pregnant women with malaria.
Corrigendum: Effect of a high dose atorvastatin as added-on therapy on symptoms and serum AMPK/NLRP3 inflammasome and IL-6/STAT3 axes in patients with major depressive disorder: randomized controlled clinical study.
Front Pharmacol
August 2024
Article Synopsis
- The text discusses a correction to a previously published article in the journal Pharmacology.
- The correction specifically addresses errors in the original study, ensuring accurate representation of the research findings.
- This update is important for maintaining the integrity of scientific literature and providing clear information to readers.
Article Synopsis
- Multisystem Inflammatory Syndrome in Children (MIS-C) linked to COVID-19 can cause serious heart issues, and Anakinra might help by reducing inflammation and improving heart function.
- A systematic review analyzed studies on Anakinra's effects on cardiac outcomes in MIS-C patients, finding significant improvements in heart metrics and inflammation in several studies, although some results were mixed.
- Despite promising findings on Anakinra's potential benefits, the data mainly come from observational studies, highlighting the need for more rigorous randomized controlled trials to confirm its effectiveness and refine treatment strategies.
Article Synopsis
- Cervical cancer in India is largely caused by HPV and has high morbidity and mortality rates, emphasizing the need for understanding regional HPV prevalence for effective public health strategies.
- A systematic review and meta-analysis examined 17 studies with 2,529 cervical cancer cases, finding a pooled HPV prevalence of 85%, but noted substantial regional variations across different parts of India.
- Results indicate the importance of further research due to the complex epidemiology of HPV, as significant differences in prevalence were observed in various geographic zones within the country.
Article Synopsis
- Researchers are exploring drug discovery strategies to fight the human monkeypox virus (MPXV) due to the lack of effective treatments.
- A network-based approach identified 160 proteins involved with MPXV, revealing 39 key proteins for potential drug targets, including 15 existing medications.
- Four specific drugs (Baricitinib, Infliximab, Adalimumab, and Etanercept) and a new molecule (ZINC22060520) show promise for repurposing to treat MPXV infection.
Effect of a high dose atorvastatin as added-on therapy on symptoms and serum AMPK/NLRP3 inflammasome and IL-6/STAT3 axes in patients with major depressive disorder: randomized controlled clinical study.
Front Pharmacol
May 2024
Article Synopsis
- - The study explored how high doses of atorvastatin, a cholesterol-lowering drug known for its anti-inflammatory properties, can affect major depressive disorders (MDD) by analyzing various biological markers in patients.
- - In a trial with 60 MDD patients, those taking atorvastatin (80 mg) along with fluoxetine showed significantly greater improvements in depressive symptoms compared to those taking fluoxetine and a placebo, including better responses and higher remission rates.
- - The results suggest that atorvastatin might serve as an effective additional treatment for MDD by influencing specific inflammatory pathways, presenting a potential new avenue for depression therapy.
Purpose: In the wake of the COVID-19 pandemic, vaccines have been pivotal in curbing disease spread and severity. However, concerns over post-vaccination adverse events, including uveitis, an inflammatory ocular condition, have been noted. This systematic review and meta-analysis aimed to evaluate the incidence and association of uveitis following COVID-19 vaccination.
View Article and Find Full Text PDFBackground: The unprecedented emergence of the COVID-19 pandemic necessitated the development and global distribution of vaccines, making the understanding of global vaccine acceptance and hesitancy crucial to overcoming barriers to vaccination and achieving widespread immunization.
Objective: This umbrella review synthesizes findings from systematic reviews and meta-analyses to provide insights into global perceptions on COVID-19 vaccine acceptance and hesitancy across diverse populations and regions.
Methods: We conducted a literature search across major databases to identify systematic reviews and meta-analysis that reported COVID-19 vaccine acceptance and hesitancy.
Wild birds could be a reservoir of medically relevant microorganisms, particularly multidrug-resistant Enterococcus spp. Resistant bacteria's epidemiology and transmission between animals and humans has grown, and their zoonotic potential cannot be ignored. This is the first study to evaluate the status of vancomycin resistant enterococci (VRE) in various wild bird species using meta-analysis and a systematic review.
View Article and Find Full Text PDFBackground: Cardiovascular disease (CVD) and dengue are both significant global health concerns, and their intersection presents a growing clinical challenge. Emerging evidence suggests that individuals with pre-existing CVD may face an elevated risk of severe dengue outcomes. The present study aims to perform a systematic review to assess the relationship between CVD and the severity of dengue.
View Article and Find Full Text PDFAn updated review on pathogenic coronaviruses (CoVs) amid the emergence of SARS-CoV-2 variants: A look into the repercussions and possible solutions.
J Infect Public Health
November 2023
SARS-CoV-2, responsible for COVID-19, shares 79% and 50% of its identity with SARS-CoV-1 and MERS-CoV, respectively. It uses the same main cell attachment and entry receptor as SARS-CoV-1, which is the ACE-2 receptor. However, key residues in the receptor-binding domain of its S-protein seem to give it a stronger affinity for the receptor and a better ability to hide from the host immune system.
View Article and Find Full Text PDFDespite the effectiveness of current vaccines in reducing the spread and severity of SARS-CoV-2 infections, many people, including migrants, refugees, and foreign workers, are hesitant to be vaccinated. This systematic review and meta-analysis (SRMA) was conducted to determine the pooled prevalence estimate of the acceptance and hesitancy rates of the COVID-19 vaccine among these populations. A comprehensive search of the peer-reviewed literature indexed in PubMed, Scopus, Science Direct, and Web of Science databases was conducted.
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