Local endoscopic removal of duodenal carcinoid tumors.

A swift and aggressive diagnostic and therapeutic approach is advisable when managing submucosal or polypoid lesions in the duodenum, since it is not possible to distinguish small, benign, and unremarkable duodenal growths macroscopically from malignant tumors such as carcinoids. This paper presents a systematic review of the published literature listed in Medline, focusing on the results after endoscopic treatment of duodenal carcinoids during the last 15 years; on the biological behavior of duodenal carcinoids; and on the endoscopic appearance of duodenal carcinoids. Endoscopic ultrasonography (EUS) is extremely useful in the diagnostic and preoperative work-up.

Parasympathetic non-adrenergic, non-cholinergic-induced protein synthesis and mitogenic activity in rat parotid glands.

Electrical stimulation of the parasympathetic auriculo-temporal nerve (40 Hz, 30 min), in the anaesthetized rat under - and -adrenoceptor blockade, increased [3H]thymidine and [3H]leucine uptake into the parotid glands by 80 and 263 %, respectively. The increase in response to parasympathetic stimulation was almost the same ([3H]thymidine 82 % and [3H]leucine 283 %) when atropine (2 mg kg-1 I.P.

Adipose tissue distribution in postmenopausal women with adenomatous hyperplasia of the endometrium.

Objective: To investigate body fat distribution in postmenopausal women with adenomatous and atypical hyperplasia of the endometrium.

Methods: A prospective population-based case control study was performed in a health care county in Sweden. General obesity, as reflected by body mass index (BMI), and adipose tissue distribution, expressed as waist to hip circumference ratio (WHR), were evaluated in a cohort of 367 postmenopausal women who underwent dilatation and curettage because of uterine bleeding.

Vascular protein leakage in the rat parotid gland elicited by reflex stimulation, parasympathetic nerve stimulation and administration of neuropeptides.

Evans blue accumulated in parotid glands of conscious rats in response to feeding (over 60 min), in the absence of atropine and adrenoceptor antagonists and in their presence, and after pretreatment with the sensory neurotoxin capsaicin. Stimulation of the auriculo-temporal nerve (40 Hz, 10 or 20 min), without and with the blockers, caused Evans blue to accumulate. A periglandular oedema also contained the dye.

Benign epithelioid schwannoma.

Benign schwannoma (neurilemoma) has various morphologic patterns that may cause problems in differential diagnosis. Although an epithelioid variant of malignant schwannoma simulating carcinoma and melanoma is well recognized, a benign counterpart has not yet been defined. In the current study, we describe five cases of benign epithelioid schwannoma that were in the subcutis (four cases) and the neck of the urinary bladder (one case).

Molecular analysis of uterine leiomyomas using the probes D7S13(7q) and HSPA2(14q).

Human uterine leiomyomas, mostly cytogenetically characterized, were analyzed by Southern blotting. The region 7q22.3-q31.

Cytogenetics of parametrial leiomyoma.

The cytogenetical findings from a parametrial leiomyoma are presented. The results, together with those of five previously presented cases, show obvious differences when compared to the chromosomal findings in uterine myomas. Ontogenic factors are proposed to be causative for the cytogenetical differences.

Histopathological findings in women with postmenopausal bleeding.

Objective: To investigate endometrial histopathology in a geographically defined population of women presenting with postmenopausal bleeding.

Design: Prospective study with collection of data during an 18-month period.

Setting: The health care county of Skaraborg, Sweden.

A study on the oncogenes gli, fos, jun and met in human uterine leiomyomas.

122 human uterine leiomyomas, representing the main chromosomal aberrations seen in these tumours, were analyzed by Southern blotting. Probes for the four oncogenes, gli, fos, jun, and met, all localized in or close to the chromosomal breakpoints in leiomyomas, were used. In only one single leiomyoma, with a 7p+q- marker, was there evidence of rearrangement of one of the oncogenes, namely met.

Cytogenetical observations and hormone receptor expression in five extra-uterine leiomyomas.

The chromosomes were studied by an in vitro technique in four parametrial and one gastric leiomyomas. The findings in parametrial myomas (the present four cases and one published earlier) differed from the observations in uterine cases by the absence of normal stemlines and the absence of 1p,6p and 7q changes. As has been shown earlier for intraocular melanomas, the location within an organ or organ system could be the explanation for the chromosomal differences.

Aggressive angiomyxoma of the vulva: an unusual, deceptive and recurrence-prone tumour with evidence of estrogen receptor expression. Case report.

Positive staining for estrogen receptors is reported in a new case of aggressive angiomyxoma of the vulva. Clinical, light- and electron microscopic features as well as immunohistochemical reactions in this case are compared with the 28 earlier published cases, and the main differential diagnosis, angiomyofibroblastoma of the vulva, is discussed.

Benign parotid oncocytoma with the chromosomal abnormality trisomy 7.

This report concerns the first cytogenetical study of a benign salivary gland oncocytoma. The cultured tumor was studied in five consecutive preparations. The first three were dominated by cells with a normal karyotype.

Cytogenetics of multiple uterine leiomyomas, parametrial leiomyoma and disseminated peritoneal leiomyomatosis.

Using banding techniques the chromosomes were studied in 15 leiomyomas. The material comprised nine uterine myomas from one patient, one parametrial leiomyoma from a second patient and five tumors from a third patient with disseminated peritoneal leiomyomatosis. The results were considered together with pooled data from the literature.

Chromosomal patterns in human benign uterine leiomyomas.

Chromosomal observations by banding technique in 18 short-term cultured human uterine leiomyomas are reported. Half of the tumors had a primary or secondary abnormal stemline. They were usually characterized only by structural changes, in particular reciprocal translocations or insertions.

Ependymoma of the ovary. A clinico-pathologic, ultrastructural and immunohistochemical investigation. A case report.

A case of primary malignant ovarian ependymoma is described. The course of the tumor disease was extremely prolonged with a 50 year history. The diagnosis is supported by immunohistochemical and ultrastructural evidence of ependymal differentiation.

Similar chromosomal evolution in a uterine stromomyosarcoma and in one of two leiomyomas from the same patient.

The chromosomes from three uterine tumours found in the same patient, two benign leiomyomas (L22 and L23) and a low-grade stroma cell sarcoma with leiomyomatous differentiation (L24), were studied by banding technique. L23 had an abnormal stemline distinguished by triosomy 12. The sarcoma showed a stemline with the same 7q-marker as L23 plus a marker del (12)(q13-24).

Cytogenetic observations in a human gastric leiomyosarcoma.

The chromosomes of a human gastric leiomyosarcoma were studied in preparations from short-term cultures. The tumor had a triploid-near-triploid modal population characterized by extensive numerical and structural changes. Of these deviations, del(1)(p12-13), monosomy 14, and underrepresentation of chromosomes 18 and 22 were abnormalities in common with two of the three previously studied leiomyosarcomas of the small bowel.

Cytogenetic relationship between uterine lipoleiomyomas and typical leiomyomas.

The chromosomes from two human uterine lipoleiomyomas, L25 and L26, from the same patient, were studied by a banding technique applied to preparations from short-term cultures. Both tumors displayed the same pseudodiploid stemline characterized by the reciprocal translocation t (5; 12) (q12; q24). These observations coincide with the previous finding that the largest subgroup of typical leiomyomas with an abnormal stemline are characterized by a long-arm change of one chromosome No.

Cytogenetical observations in human benign uterine leiomyomas.

Detailed observations by banding technique in 21 cultured human benign uterine leiomyomas are reported. More than half of the tumors (51%) had a primary or secondary abnormal stemline. The abnormal stemlines were usually characterized only by structural changes, in particular reciprocal translocations.