Applications of hyperpolarized agents in solutions.

This chapter provides an overview of pulse sequences adapted to hyperpolarized MR imaging. Applications of hyperpolarized agents in aqueous solution are reviewed. Vascular (e.

Hyperpolarized molecules in solution.

Hyperpolarization is a technique to enhance the nuclear polarization and thereby increase the available signal in magnetic resonance (MR). This chapter provides an introduction to the concept of hyperpolarization as well as an overview of dynamic nuclear polarization (DNP) and para-hydrogen induced polarization (PHIP), two methods used to generate hyperpolarized molecules in aqueous solution.

Trityl biradicals and 13C dynamic nuclear polarization.

The objective of this study is to investigate if trityl biradicals could lead to more efficient dynamic nuclear polarization (DNP) for low gamma nuclear spins at low temperature (approximately 1 K) than a trityl monoradical. Three novel trityl biradicals of different size are synthesized, characterized and employed for hyperpolarization of [1-(13)C]pyruvic acid at 3.35 T and 4.

Dynamic Nuclear Polarization of [1-13C]pyruvic acid at 4.6 tesla.

Dynamic Nuclear Polarization (DNP) of the (13)C nucleus has been investigated for [1-(13)C]pyruvic acid, doped with the trityl radical OX063Me, at 4.64 T and 1.15K.

Hyperpolarization of 13C through order transfer from parahydrogen: a new contrast agent for MRI.

The order within proton pairs in organic molecules, resulting from hydrogenation with parahydrogen, can be transferred in great part to nearby carbon 13 spins through adequate field manipulations. The molecules with hyperpolarized 13C thus obtained can be used as new contrast agents of high efficiency in MRI. After a brief presentation of the hydrogenation process and apparatus, in relatively low magnetic field, we describe the procedure of order transfer to the 13C spins through a sudden drop from the initial field to zero field followed by an adiabatic remagnetization.