Publications by authors named "Haugen I"
Enteroviruses can infect various human organs, causing diseases such as meningitis, the common cold, hand-foot-and-mouth disease, myocarditis, pancreatitis, hepatitis, poliomyelitis, sepsis, and type 1 diabetes. Currently, there are no approved treatments for enterovirus infections. In this study, we identified a synergistic combination of orally available, safe-in-man pleconaril, AG7404, and mindeudesivir, that at non-toxic concentrations effectively inhibited enterovirus replication in human cell and organoid cultures.
View Article and Find Full Text PDFPurpose: Being a young carer of a parent with dementia can be challenging, with many carers undertaking various practical and caring tasks. The weekend course Time to be young? gathers young carers, aiming to support them to cope with their challenges in everyday life. The aim of this study was to explore their role as a caregiver and the experienced impact of the course on their strategies of coping in their everyday life.
View Article and Find Full Text PDFObjective: Previous studies on the efficacy of methotrexate in people with hand osteoarthritis (OA) have shown conflicting results. The MERINO trial aims to investigate the efficacy and safety of methotrexate in people with painful inflammatory erosive hand OA.
Design: In total 163 participants with erosive hand OA, synovitis by ultrasound, and finger joint pain of 40-80 mm on a visual analogue scale (VAS) will be recruited from a rheumatology outpatient clinic.
Background: We aimed to update the 2018 systematic literature review on the efficacy and safety of treatments for hand osteoarthritis (OA), which was based on 126 studies.
Methods: We performed a systematic literature search on randomised controlled trials from June 2017 up to 31 December 2023. Risk of bias was assessed using the RoB2 tool.
Objective: We aimed to explore how specific cognitive processes, such as attention and executive functions, account for variance in decision-making measured by Iowa Gambling Task (IGT) performance among individuals with schizophrenia spectrum disorders.
Methods: Adults ( = 65, = 25.4) with schizophrenia spectrum disorders participating in a clinical trial (registered at clinicaltrials.
Background: Whether fibromyalgia burden is related to measures of sensitization, assessed by quantitative sensory testing (QST), is not clear. We examine the associations between sensitization and fibromyalgia disease burden as measured by the polysymptomatic sistress scale (PDS) and the fibromyalgia impact questionnaire (FIQ) (range 0-100).
Materials And Methods: Participants were recruited from referrals to a rheumatology outpatient clinic and the fibromyalgia diagnosis was verified by a rheumatologist.
Objective: Our primary objectives are to assess whether intraarticular corticosteroid injections are superior to saline injections with regards to thumb base pain after 4 weeks, and to compare the efficacy of steroid injections, saline injections, and an occupational therapy intervention on thumb base pain after 12 weeks in people with painful inflammatory osteoarthritis (OA) of the first carpometacarpal (CMC-1) joint.
Design: In this three-armed, double-blind, randomized multicenter trial, 354 participants with painful inflammatory CMC-1 OA from six Norwegian hospitals are recruited. Participants are randomized 1:1:1 to intraarticular steroid or saline injections in the CMC-1 joint or a multimodal occupational therapy intervention.
Longitudinal stability of molecular endotypes of knee osteoarthritis patients.
Osteoarthritis Cartilage
January 2025
Objective: To assess the longitudinal stability of biomarker-based molecular endotypes of knee osteoarthritis (KOA) participants from APPROACH and to evaluate the consistency of findings in an independent KOA population.
Methods: Nineteen biomarkers were measured longitudinally in 295 KOA participants from the APPROACH cohort. K-means clustering was used to identify the structural damage, inflammation, and low tissue turnover endotypes at the six-, 12-, and 24-month follow-ups.
Objective: To generate a list of candidate items potentially useful for discriminating individuals with Early-stage Symptomatic Knee Osteoarthritis (EsSKOA) from those with other conditions and from established osteoarthritis (OA), and to reduce this list based on expert consensus.
Design: We conducted a three-round online international modified Delphi exercise with OA clinicians and researchers ("OA experts"). In Round 1, participants reviewed 84 candidate items and nominated additional item(s) potentially useful for EsSKOA classification; those nominated by ≥3 participants were added.
Article Synopsis
- The study aimed to see if changes in MRI-defined bone marrow lesions (BMLs) and inflammatory markers are linked to cartilage loss in knees with osteoarthritis over 24 months.
- It analyzed data from 629 participants, finding that knees with no BMLs showed significantly less cartilage loss, while those with increasing BML size experienced more cartilage loss.
- The results suggest that preventing the growth of BMLs and worsening of Hoffa-synovitis could help reduce cartilage deterioration in osteoarthritis patients.
Article Synopsis
- The study looked at people with and without hand osteoarthritis to find out who has marginal erosions (MEs), which are small damage spots in the bones.
- It discovered that MEs are more common in older men who smoke and usually happen in joints that don’t have a lot of arthritis.
- Lastly, MEs could help predict how the condition might get worse over time, since they are linked to more changes in bone damage compared to joints without MEs.
Objective: To investigate whether structural hand OA or its progression is associated with structural knee OA progression after two years in a population with symptomatic knee OA.
Methods: We used baseline and two-year follow-up data from the IMI-APPROACH cohort. Symptomatic hand and knee OA were defined using ACR criteria.
Objectives: The objective of this study is to develop classification criteria for overall hand osteoarthritis (OA), interphalangeal OA and thumb base OA based on self-reported data and radiographic features.
Methods: The classification criteria sets were developed in three phases. In phase 1, we identified criteria that discriminated hand OA from controls.
Background: Diabetic retinopathy (DR) is the leading cause of adult blindness in the working age population worldwide, which can be prevented by early detection. Regular eye examinations are recommended and crucial for detecting sight-threatening DR. Use of artificial intelligence (AI) to lessen the burden on the healthcare system is needed.
View Article and Find Full Text PDFObjective: Hand osteoarthritis (OA) pain is characterized as heterogeneous and multifactorial. Differences in pain may be explained by underlying phenotypes, which have not been previously explored DESIGN: Latent class analysis determined classes of participants with hand OA from the Nor-Hand study baseline examination (2016-17) based on a biopsychosocial framework. Outcomes were hand and overall bodily pain intensity (Numeric Rating Scale, 0-10) at baseline and follow-up (2019-21), The relations of the classes to pain outcomes at baseline, follow-up, and change over time were analysed in separate models by linear regression, using the overall healthiest class as reference.
View Article and Find Full Text PDFArticle Synopsis
- The study introduces a deep learning framework using attention mechanisms to predict the progression of patellofemoral osteoarthritis (PFOA) over seven years, based on knee X-ray imaging.
- It involved 1,832 subjects and utilized an automated tool for analyzing knee images, comparing the deep learning model's performance against traditional risk factors like age and BMI.
- Results indicated that the deep learning model with attention outperformed other models, achieving an AUC of 0.856, and combining imaging and clinical data in an ensemble model provided slightly better predictions with an AUC of 0.865.
Objective: To determine the association between joint structure and gait in patients with knee osteoarthritis (OA).
Methods: IMI-APPROACH recruited 297 clinical knee OA patients. Gait data was collected (GaitSmart®) and OA-related joint measures determined from knee radiographs (KIDA) and MRIs (qMRI/MOAKS).
Persons with schizophrenia often show executive dysfunction assessed with both subjective (self-report) and objective (neuropsychological tests) measures. In a recent randomized controlled trial (RCT), subjective executive functioning in everyday life was improved following Goal Management Training (GMT). The aim of the current study is to investigate the potential of GMT to improve secondary well-being outcomes from that RCT, including self-esteem, self-efficacy, and quality of life in persons with schizophrenia spectrum disorders.
View Article and Find Full Text PDFArticle Synopsis
- The study aims to analyze cytokine levels in the tear fluid of patients undergoing multiple intravitreal injections (IVI) of anti-VEGF for treating neovascular age-related macular degeneration (nAMD).
- Researchers measured the levels of six cytokines in the tears of treated and untreated eyes of patients, using a specific assay technique, at least four weeks after receiving an injection.
- Results showed that levels of two pro-inflammatory cytokines, IFN-γ and TNF, were lower in the injected eyes compared to the untreated eyes, supporting the notion that serial IVI treatment correlates with reduced inflammation and improved tear film health.
Article Synopsis
- Erosive hand osteoarthritis (eHOA) is a specific type of hand osteoarthritis that occurs in fingers already affected by OA, characterized by inflammation, pain, disability, and joint erosions.
- The study used data from the Osteoarthritis Initiative, analyzing hand radiographs and serum biomarkers over 48 months to identify participants who developed incident radiographic eHOA.
- Results indicated that higher levels of interleukin-7, an inflammatory cytokine, are linked to the development of eHOA, suggesting it may contribute to inflammation and joint damage in affected individuals.
Background: Colchicine has been suggested for osteoarthritis treatment, but evidence is contradictory. We aimed to investigate colchicine's efficacy and safety compared with placebo in people with hand osteoarthritis.
Methods: In this single-centre, double-blind, randomised, placebo-controlled trial we recruited adults with symptomatic hand osteoarthritis and finger pain of at least 40 mm on a 100 mm visual analogue scale from an outpatient clinic in Denmark.
Objectives: There is no evidence linking specific osteoarthritis (OA) types, such as erosive hand OA (EHOA), with distant generalised changes in muscle composition (sarcopenia), which can potentially be modified. This study pioneers the exploration of the association between EHOA and sarcopenia, both of which are predominantly observed in the older adults.
Methods: Using the Osteoarthritis Initiative cohort, we selected hand OA (modified Kellgren and Lawrence (grade ≥2 in ≥1 hand joint) participants with radiographic central erosions in ≥1 joints (EHOA group) and propensity score-matched hand OA participants with no erosion (non-EHOA group).
Purpose: Advancing age is one of the strongest risk factors for osteoarthritis (OA). DNA methylation-based measures of epigenetic age acceleration may provide insights into mechanisms underlying OA.
Methods: We analyzed data from the Multicenter Osteoarthritis Study in a subset of 671 participants ages 45-69 years with no or mild radiographic knee OA.
Objective: As part of the first phase of the OARSI Early-stage Symptomatic Knee Osteoarthritis (EsSKOA) initiative, we explored the first symptoms and experiences recalled by individuals with knee osteoarthritis (OA).
Design: This qualitative study, informed by qualitative description, was a secondary analysis of focus groups (n = 17 groups) and one-on-one interviews (n = 3) conducted in 91 individuals living with knee OA as part of an international study to better understand the OA pain experience. In each focus group or interview, participants were asked to describe their first symptoms of knee OA.