Modulation of Fe-Fe distance and spin in diiron complexes using tetradentate ligands with different flanking donors.

Here we report the synthesis and characterization of diiron complexes containing triaryl N and NS ligands derived from -phenylenediamine. The complexes display significant differences in Fe-Fe distances and magnetic properties that depend on the identity of the flanking NMe and SMe donor groups.

The Effects of Lithium Chloride Exposure on the Reproduction of .

( are model organisms that share similar anatomical structures to humans. By exploring the effects of lithium chloride (LiCl) on we can collect crucial data regarding the compound's impact on patients taking psychiatric medications containing LiCl. Here we performed an egg retention assay on nematode populations to explore how LiCl can influence reproduction.

Liver Biopsy: To Do or Not to Do - A Single-Center Study.

Introduction: A variety of liver disorders are associated with characteristic histopathological findings that help in their diagnosis and treatment. However, percutaneous liver biopsy (PLB) is prone to limitations and complications. We evaluated all PLBs done in our hospital in a 13-year period, aiming to assess PLB's utility and complications.

Single Nucleotide Polymorphisms of Toll-like Receptor 4 in Hepatocellular Carcinoma-A Single-Center Study.

Hepatocellular carcinoma (HCC) is the most common primary liver tumor leading to significant morbidity and mortality; its exact genetic background is largely unrecognized. Toll-like receptor-4 (TLR4) reacts with lipopolysaccharides, molecules found in the outer membrane of Gram-negative bacteria. In damaged liver, TLR4 expression is upregulated, leading to hepatic inflammation and injury.

Redox chemistry and H-atom abstraction reactivity of a terminal zirconium(iv) oxo compound mediated by an appended cobalt(i) center.

The reactivity of the terminal zirconium(iv) oxo complex, O[triple bond, length as m-dash]Zr(MesNPPr)CoCN Bu (), is explored, revealing unique redox activity imparted by the pendent redox active cobalt(i) center. Oxo complex can be chemically reduced using Na/Hg or PhC to afford the Zr/Co complexes [(μ-Na)OZr(MesNPPr)CoCN Bu] () and PhCOZr(MesNPPr)CoCN Bu (), respectively. Based on the cyclic voltammogram of , Ph˙ should not be sufficiently reducing to achieve the chemical reduction of , but sufficient driving force for the reaction is provided by the nucleophilicity of the terminal oxo fragment and its affinity to bind PhC.

Metal-ligand cooperativity across two sites of a square planar iron(ii) complex ligated by a tetradentate PNNP ligand.

An iron(ii) complex with a square planar geometry and S = 1 ground state was synthesized using a rigid tetradentate bisphosphine-bisamide [PNNP]2- ligand. This complex was shown to bind an equivalent of PMe3 to produce a five-coordinate low spin complex, and to react with two equivalents of borane reagents via addition of two B-H bonds across the metal-amide bonds in a metal-ligand cooperative fashion.

Causative factors of liver fibrosis in HIV-infected patients. A single center study.

Background: Liver disease is a leading cause of morbidity and mortality among Human Immunodeficiency virus (HIV) infected patients; however no consensus exists on HIV-related risk factors for it. The aim of this study was to identify risk factors for liver fibrosis/cirrhosis in a cohort of Greek HIV-infected patients.

Methods: Patients attending the HIV outpatient clinic of Pathophysiology Department at «Laiko» General Hospital in Athens, Greece, between December 2014 and December 2017 were eligible for inclusion.

Liver Fibrosis Assessment in a Cohort of Greek HIV Mono-Infected Patients by Non-Invasive Biomarkers.

Background: Non-alcoholic Fatty Liver Disease (NAFLD) is common in HIV-infected individuals. Liver biopsy remains the gold-standard procedure for the diagnosis of liver fibrosis, but both Transient Elastography (TE) and Non-invasive Biomarkers (NIBMs) have emerged as alternatives.

Objectives: Our study's aim was to validate commonly used NIBMs for the assessment of liver fibrosis in a cohort of Greek HIV-mono-infected patients.

O Activation by a Heterobimetallic Zr/Co Complex.

Oxygen reduction is a critical half reaction in renewable fuel cell development and a key step in the development of aerobic oxidation reactions. Herein, we report rapid two-electron O reduction by a d Zr center with an appended redox-active Co site serving as an electron reservoir. The early/late heterobimetallic Zr/Co complex (THF)Zr(MesNP Pr)CoCN Bu (1) reacts readily with O and O atom transfer reagents to generate reactive oxygenated species including terminal peroxo and oxo complexes, (O)Zr(MesNP Pr)CoCN Bu (2) and O≡Zr(MesNP Pr)CoCN Bu (3).

Management of Patients with Heart Failure: Focus on New Pharmaceutical and Device Options.

Hospitalization rates and survival of patients with Heart Failure (HF) have improved. However, 5-year mortality rates remain high and the prevalence of the disease is rising likely due to aging of the population and advances in diagnosis and treatment of other acute and chronic cardiovascular diseases. Over the past three decades the therapeutic armamentarium of heart failure has improved substantially with development of medications targeting neuro-hormonal activation and devices preventing sudden cardiac death and improving cardiac synchrony.

Assessing the Metal-Metal Interactions in a Series of Heterobimetallic Nb/M Complexes (M = Fe, Co, Ni, Cu) and Their Effect on Multielectron Redox Properties.

A one-pot synthetic procedure for a series of bimetallic Nb/M complexes, Cl-Nb( PrNPPh)M-X (M = Fe (2), Ni (4), Cu (5)), is described. A similar procedure aimed at synthesizing a Nb/Co analogue instead affords PrN═Nb( PrNPPh)(μ-PPh)Co-I (3) through cleavage of one phosphinoamide P-N bond under reducing conditions. Complexes 4 and 5 are found to have short Nb-M distances, corresponding to unusual metal-metal bonds between Nb and these first row transition metals.

Clinical predictors of outcome in patients with inflammatory dilated cardiomyopathy.

Objectives: The study objectives were to identify predictors of outcome in patients with inflammatory dilated cardiomyopathy (DCMi).

Methods: From 2004 to 2008, 55 patients with biopsy-proven DCMi were identified and followed up for 58.2±19.

Circulating autoantibodies to endogenous erythropoietin are associated with chronic hepatitis C virus infection-related anemia.

Background: Chronic hepatitis C virus (HCV) infection is associated with autoimmune phenomena and is often complicated by anemia. Circulating autoantibodies to endogenous erythropoietin (anti-EPO) have been detected in patients with chronic viral infections and were correlated to anemia. The present study aimed to determine anti-EPO prevalence in patients with chronic HCV infection and investigate its possible association with anemia.

Decreased serum DNase1-activity in patients with autoimmune liver diseases.

Deoxyribonuclease1 (DNase1) is involved in chromatin degradation of apoptotic cells. Its deficiency results in accumulation of self-DNA, which in turn may induce inflammation and autoimmunity. We assessed for the first time serum DNase1-activity in a large consecutive cohort of treatment-naïve patients with autoimmune liver diseases (ALD).

Socioeconomic status and risk factors for cardiovascular disease: Impact of dietary mediators.

It is well known that cardiovascular disease is the leading cause of mortality in the western societies. A number of risk factors such as family history, diabetes, hypertension, obesity, diabetes, smoking and physical inactivity are responsible for a significant proportion of the overall cardiovascular risk. Interestingly, recent data suggest there is a gradient in the incidence, morbidity and mortality of cardiovascular disease across the spectrum of socioeconomic status, as this is defined by educational level, occupation or income.

Coronary Artery Atherosclerosis in Hypertensive Patients: The Role of Fibrinogen Genetic Variability.

Introduction And Objectives: We examined whether the rs180070 and rs2070011 polymorphisms of the fibrinogen gene could affect the risk of coronary artery disease in hypertensive patients by modifying the inflammatory process and coagulation.

Methods: A total of 744 participants underwent coronary angiography due to symptoms of stable angina, while hypertension was present in 332 patients.

Results: The presence of the A allele (rs180070) was associated with significantly high levels of fibrinogen in hypertensive patients (P=.

Association of antiviral therapy with reduced disease progression in chronic Hepatitis B patients: Results from a nation-wide cohort study.

Background And Aims: Although effective treatment in terms of inducing virological and biochemical response for chronic hepatitis B (CHB) is available, its effect on the clinical course of the disease has not yet been accurately estimated. Objective of this study was to evaluate the effect of antiviral therapy and its type [interferon +/- nucleos(t)ide analogs (NAs) vs. NAs] on the occurrence of a clinical event (liver decompensation, liver transplant, hepatocellular carcinoma and death from a liver-related cause) in CHB patients.

A case report of successful treatment of pyoderma gangrenosum in a patient with autoimmune hepatitis, and review of the literature.

Background: Pyoderma Gangrenosum (PG) is a cutaneous condition, its diagnosis suggested by the presence of a painful cutaneous ulcer showing rapid progression. Pyoderma gangrenosum is associated with a concomitant systemic disease in 50 to 70 % of cases, including inflammatory bowel disease (IBD), rheumatoid arthritis, and lymphoproliferative disorders. Although PG has also been reported with viral hepatitis, it is rarely associated with autoimmune hepatitis.

Atorvastatin treatment improves endothelial function through endothelial progenitor cells mobilization in ischemic heart failure patients.

Objective: Endothelial function is an independent predictor of prognosis in heart failure (HF) subjects. Statins, beyond their lipid lowering role, exert beneficial effect in patients with atherosclerosis. In the present study we examined the impact of low and intermediate dose atorvastatin treatment on endothelial function, bone marrow-derived endothelial progenitor cells (EPC) mobilization and inflammatory status according to HF patient status.

Inflammation and chronic heart failure: from biomarkers to novel anti-inflammatory therapeutic strategies.

Heart failure (HF) is a complex heterogeneous syndrome with immune, metabolic and neurohumoral mechanisms interacting and leading to gradual heart contractility impairment. From the first study-to correlate inflammation with HF, inflammation biomarkers have been the subject of intense inquiry in patients with various forms of HF. Chronic HF (CHF) is strongly associated with inflammation in terms of pathogenesis, progression, severity and prognosis.

Hepatocellular carcinoma risk in HBeAg-negative chronic hepatitis B patients with or without cirrhosis treated with entecavir: HepNet.Greece cohort.

Hepatocellular carcinoma (HCC) may still develop in chronic hepatitis B (CHB) patients treated with lamivudine. Whether HCC rates are comparable in patients treated with the current first-line antivirals remains uncertain. We estimated the incidence and evaluated predictors of HCC in a large nationwide prospective cohort (HepNet.