Fish oil omega-3 fatty acids reduce the severity of radiation-induced oxidative stress in the rat brain.

Purpose: To evaluate the modulator role of fish oil (FO) on some biochemical changes in the brain of gamma-irradiated rats (RAD).

Material And Methods: Male albino rats Sprague Dawley were divided into four groups (n = 10). (i)

Control: received vehicle via gavages during 28 days; (ii) FO: received fish oil (400 mg/kg/day) via gavages during 28 days; (iii) RAD: received vehicle for 7 days before whole body gamma-irradiation with 8 Gy given in four fractions each 7 days apart and continued during the irradiation period; and (iv) FO+ RAD: received FO for 7 days before exposure to the first dose of irradiation and FO treatment was continued during the irradiation period.