The determination of causality of drug induced liver injury in patients with COVID-19 clinical syndrome.

Background: Drug induced liver injury (DILI) is a rising morbidity amongst patients with COVID-19 clinical syndrome. The updated RUCAM causality assessment scale is validated for use in the general population, but its utility for causality determination in cohorts of patients with COVID-19 and DILI remains uncertain.

Methods: This retrospective study was comprised of COVID-19 patients presenting with suspected DILI to the emergency department of Weill Cornell medicine-affiliated Hamad General Hospital, Doha, Qatar.

Mindfulness and psychological distress among hemodialysis patients.

The current study identifies the unique role of trait mindfulness in improving the psychological health of patients under hemodialysis. A correlational research design was employed with a sample of 221 patients under hemodialysis. Participants completed a survey about the basic demographics, psychological distress, and mindfulness.

Left ventricular metastasis of osteosarcoma: A report of an unusual case.

Background: Secondary cardiac tumors are far more frequent than primary tumors. Cardiac metastasis of osteosarcoma is extremely rare.

Case Presentation: We report a 14-year-old child with left femur osteosarcoma that had metastasized to the left ventricle after 30 months of follow-up.

[Inferior myocardial infarction: first Moroccan study of 103 cases].

Myocardial infarction (MI) is a major cause of cardiovascular mortality. Inferior MI accounts for 30-50% of infarctions but it is associated with a favorable prognosis compared to anterior infarct. This study aimed to study the epidemiological, clinical, electrical, echocardiographic, angiographic features of inferior MI, as well as its complications and its therapeutic approaches.

[Perforated posterior mitral valve aneurysm: a rare complication of infective endocarditis: a case report].

Mitral valve aneurysm is a rare abnormality whose pathophysiology is poorly understood. It is defined as a bulge of the mitral valve leaflet toward the left atrium. Aneurysm in the posterior leaflet is exceptional.

Double talon cusps on supernumerary tooth fused to maxillary central incisor: Review of literature and report of case.

Human tooth development is a continuous process begin at the sixth weeks in utero and extends to about sixth months after birth for the primary dentition and from sixteenth week in utero to late adolescence for permanent dentition. There is no other organ of the human body which takes so long to attain its ultimate morphology as dentition. Several physiologic growth processes participate in the progressive development of the teeth including: initiation, proliferation, histodifferentiation, morphodifferentiation, apposition, calcification, and eruption.

Mesiodistal crown diameters and tooth size discrepancy of permanent dentition in thalassemic patients.

Objectives: To provide a description of mesiodistal crown diameters (MD) and tooth-size discrepancy (TSD) of the permanent dentition in patients with thalassemia major (TM) and to compare the results with those of unaffected control group.

Study Design: The sample consisted of 46 thalassemic patients, 25 males and 21 females aged 7.3 to 23.

Remineralisation of carious lesions and fluoride uptake by enamel exposed to various fluoride dentifrices in vitro.

Purpose: To evaluate the relative performance of fluoride (F) dentifrices to promote remineralisation and enamel F acquisition using an in vitro pH-cycling model. Enamel surface morphology was investigated.

Materials And Methods: Thirty-six white spot lesions and 36 sound enamel sections from extracted premolars and molars were randomly assigned to 8 experimental groups and a placebo group.

Patterns of physical growth and dental development in Jordanian children and adolescents with thalassemia major.

Dental development and physical growth are of particular interest in pediatric dentistry and orthodontics. This study evaluated these variables in patients with thalassemia major (TM). Physical growth was assessed in 54 patients (31 males and 23 females) aged 5.

Periodontal condition and orofacial changes in patients with thalassemia major: a clinical and radiographic overview.

Objective: To assess the prevalence of periodontal disease, orofacial changes and craniofacial abnormalities in patients with thalassemia major (TM). Dental management is discussed

Study Design: The sample consisted of 54 patients with TM, 31 males and 23 females aged 5.5 to 18.

Dental arch dimensions in subjects with beta-thalassemia major.

Aim: Thalassemia is a group of inherited hemoglobinopathies with thalassemia major representing the severe form of the disease characterized by craniofacial deformities. The aim of this study is to provide a detailed description of dental arch dimensions in subjects with thalassemia major.

Subjects And Methods: The sample consisted of 43 thalassemic subjects, 24 males and 19 females, aged 7.

Papillon-Lefèvre syndrome with albinism: a review of the literature and report of 2 brothers.

Background: Papillon-Lefèvre syndrome (PLS) is a very rare autosomal recessive disorder characterized by palmoplantar hyperkeratosis and severe early onset of destructive periodontitis leading to premature loss of both primary and permanent dentitions. The etiopathogenesis of the condition suggests that there is a genetic basis for susceptibility to specific virulent pathogens. Variation in the clinical presentation of PLS has recently been observed.

Coinheritance of two rare genodermatoses (Papillon-Lefèvre syndrome and oculocutaneous albinism type 1) in two families: a genetic study.

The co-occurrence of two rare recessive genetic conditions in apparently unrelated individuals or families is extremely rare. Two geographically distant and apparently unrelated families were identified in which individuals were simultaneously affected by two rare recessive mendelian syndromes, Papillon-Lefevre syndrome and type 1 oculocutaneous albinism. The families were tested for mutations in the causative genes, cathepsin C (CTSC) and tyrosinase (TYR), respectively, by direct sequencing.

The role of cathepsin C in Papillon-Lefèvre syndrome, prepubertal periodontitis, and aggressive periodontitis.

We have previously reported that loss-of-function mutations in the cathepsin C gene (CTSC) result in Papillon-Lefèvre syndrome, an autosomal recessive condition characterized by palmoplantar keratosis and early-onset, severe periodontitis. Others have also reported CTSC mutations in patients with severe prepubertal periodontitis, but without any skin manifestations. The possible role of CTSC variants in more common types of non-mendelian, early-onset, severe periodontitis ("aggressive periodontitis") has not been investigated.

Maxillary canine transpositions in two brothers and one sister: associated dental anomalies and genetic basis.

Transposition is an uncommon dental anomaly involving positional interchange of two teeth. The maxillary canine is the tooth more frequently transposed in man. Maxillary canine-first premolar appears to be the most common type of tooth transposition, followed by maxillary canine-lateral incisor transposition.

Cephalometric measurements and facial deformities in subjects with beta-thalassaemia major.

This study was performed to identify cephalometric and facial features of patients with beta-thalassaemia major. A total of 54 thalassaemic subjects were examined for craniofacial deformities, including 37 patients (24 males and 13 females, aged 5-16 years) who had lateral cephalometric radiographs. The thalassaemic groups were compared with a normal control group matched for sex and dental age, using a t-test.

Oral health status of workers exposed to acid fumes in phosphate and battery industries in Jordan.

Objectives: To investigate the prevalence and nature of oral health problems among workers exposed to acid fumes in two industries in Jordan.

Setting: Jordan's Phosphate Mining Company and a main private battery factory.

Design: Comparison of general and oral health conditions between workers exposed to acid fumes and control group from the same workplace.

An unusual case of talon cusp on geminated tooth.

A rare case of talon cusp on geminated permanent central incisor is described. These developmental anomalies cause clinical problems including unsightly dental appearance, occlusal interference, displacement of the affected tooth, attrition, periodontopathy, irritation of the tongue, loss of space and malocclusion. Clinical and radiographic characteristics of these anomalies and modes of treatment are presented.

Fluoride release from glass ionomer restorative materials and the effects of surface coating.

Objectives: This in vitro study on fluoride (F) release from conventional and metal-reinforced glass ionomer investigated the following: (1) the release of F in deionized water compared to artificial saliva, (2) the effect of various surface coatings on F release, (3) the uptake of released F by hydroxyapatite, (4) the expression of the release data in a mathematical model, (5) F content in the powders and set materials, and (6) surface morphology of varnished and resin-coated specimens.

Methods: Glass ionomer Ketac-Fil (KF), Fuji II (FJ), and Ketac-Silver (KS) were mixed according to the manufacturers' instructions, and prepared into specimens of 137.8 mm2 surface area.

Caries risk in patients with thalassaemia major.

Aim: The aim of this study was to assess the prevalence and distribution of dental caries in subjects with thalassaemia major.

Design: Clinical examination for dental caries, diagnosed according to the WHO criteria.

Participants: A total of 54 thalassaemic patients, 23 aged 6-9 (14 males and 9 females) and 31 aged 12-18 (17 males and 14 females) were examined.

Etiology and diagnosis of tooth wear: a literature review and presentation of selected cases.

Purpose: This article presents an overview of etiologies associated with tooth wear.

Materials And Methods: Specific types of wear based on clinical findings and patient history are described.

Results: The occurrence and pattern of tooth wear are related to cultural, dietary, occupational, and geographic factors.