Publications by authors named "Hatim Al-Maghraby"
Iron is an essential element for brain cells that is required for the transport of oxygen, energy generation, myelin synthesis, and production of neurotransmitters. Disturbances in the homeostatic mechanisms of iron metabolism may cause iron accumulation with subsequent oxidative stress and cellular damage. It is important to consider the possibility of both a genetic and acquired iron overload syndrome in patients with neurological symptoms and hyperferritinemia.
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- Focal segmental glomerular sclerosis (FSGS) often recurs after kidney transplants, leading to graft loss in about 50% of patients, with few effective treatment options currently available.
- A case study of a 24-year-old woman highlights her struggle with FSGS recurrence post-transplant, where multiple treatments were attempted, but only cyclophosphamide ultimately led to successful remission.
- This case emphasizes the need for further research into cyclophosphamide as a treatment option for FSGS recurrence in kidney transplant patients, especially after conventional therapies fail.
Lymphomas are a heterogeneous group of diseases that encompass malignant disorders of B-cells, T-cells, or natural killer cells. B-cell lymphomas represent approximately 80-85% of cases. Transformation of B-cell lymphomas from a low grade to a higher grade within the same lineage is a well-described phenomenon.
View Article and Find Full Text PDFLangerhans cell histiocytosis (LCH) is a rare neoplasm that is caused by an uncontrolled proliferation of Langerhans cells. The clinical presentation of LCH is heterogeneous and can manifest as single or multiple osteolytic lesions, skin ulcerations, and involvement of single or multiple systems. Central nervous system (CNS) involvement is reported in 3.
View Article and Find Full Text PDFEsophageal carcinoma metastasis to the brain is very rare with less than 300 cases published worldwide. The reported incidence rates of esophageal carcinoma metastases to the brain range from 0.3% to 13%.
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- Desmoid tumors are rare mesenchymal tumors in the mesentery that are often misdiagnosed, particularly in patients with a history of gastrointestinal stromal tumor (GIST) resection.
- This article presents a unique case of a Desmoid tumor in a patient with prior GIST, marking the first reported instance of such a development in Saudi Arabia.
- The discussion includes a comparison of Desmoid tumors and GIST, covering aspects like definitions, symptoms, histology, immunohistochemistry, and their relationship, while also contrasting this case with existing literature.
Anaplastic sarcoma of the kidney (ASK) is an extremely rare tumor, which usually presents as a large renal mass. Microscopically, the tumor is composed of pleomorphic mesenchymal spindle cells with marked atypia, associated with chondroid differentiation and focal round primitive mesenchymal cells. Herein, we present a case of anaplastic sarcoma of the kidney in a 3-year-old female, who presented with a large abdominal mass.
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