Exploring the Feasibility, Acceptability, and Potential Benefits of the Mom Movement Intervention (MOMmi).

Objective: To explore the feasibility, acceptability, and potential benefits associated with a mind-body intervention and varied delivery styles among women during the postpartum period.

Design: Mixed-methods feasibility study.

Setting: Fraser Valley, British Columbia, Canada.

Psychological and physiological effects of an acute bout of yoga before a simulated academic exam in university students.

Test anxiety is common among nursing students. Yoga is one form of physical activity which may be beneficial for pretest anxiety. Thirteen undergraduate students (85% nursing majors, 15% awaiting program entry, 20 ± 4.

Bivalent non-human gal-α1-3-gal glycan epitopes in the Fc region of a monoclonal antibody model can be recognized by anti-Gal-α1-3-Gal IgE antibodies.

Monoclonal antibody (mAb) production using non-human cells can introduce non-human glycan epitopes including terminal galactosyl-α1-3-galactose (α1-3-Gal) moieties. Cetuximab is a commercial mAb associated with causing anaphylaxis in some patients due to the binding of endogenous anti-α1-3-Gal IgE to the Fab (containing bi-α1-3-galactosylated glycans) but not to the Fc region (containing mono-α1-3-galactosylated glycans). Despite being low in abundance in typical commercial mAbs, the inherent sensitivity of cell culture conditions on glycosylation profiles, and the development of novel glycoengineering strategies, novel antibody-based modalities, and biosimilars by various manufacturers with varying procedures, necessitates a better understanding of the structural requirements for anti-α1-3-Gal IgE binding to the Fc region.

Moms on the move: A qualitative exploration of a postpartum group exercise program on physical activity behaviour at three distinct time points.

Purpose: Physical activity (PA) after the birth of a child is associated with improved physical and mental health benefits. The aim of the study was to explore new mothers' experiences of PA before and after participation in a group-based PA program for new mothers. The study has three research questions: how new mothers felt; 1) about PA after the birth of their child 2) about engaging in a group-based PA program and 3) after the program ended about ongoing PA engagement.

Specific location of galactosylation in an afucosylated antiviral monoclonal antibody affects its FcγRIIIA binding affinity.

Monoclonal antibodies (mAbs) comprise an essential type of biologic therapeutics and are used to treat diseases because of their anti-cancer and anti-inflammatory properties, and their ability to protect against respiratory infections. Its production involves post-translational glycosylation, a biosynthetic process that conjugates glycans to proteins, which plays crucial roles in mAb bioactivities including effector functions and pharmacokinetics. These glycans are heterogeneous and have diverse chemical structures whose composition is sensitive to manufacturing conditions, rendering the understanding of how specific glycan structures affect mAb bioactivity challenging.

Unusual β1-4-galactosidase activity of an α1-6-mannosidase from Xanthomonas manihotis in the processing of branched hybrid and complex glycans.

Mannosidases are a diverse group of glycoside hydrolases that play crucial roles in mannose trimming of oligomannose glycans, glycoconjugates, and glycoproteins involved in numerous cellular processes, such as glycan biosynthesis and metabolism, structure regulation, cellular recognition, and cell-pathogen interactions. Exomannosidases and endomannosidases cleave specific glycosidic bonds of mannoside linkages in glycans and can be used in enzyme-based methods for sequencing of isomeric glycan structures. α1-6-mannosidase from Xanthomonas manihotis is known as a highly specific exoglycosidase that removes unbranched α1-6 linked mannose residues from oligosaccharides.

Microbiome profiles are associated with cognitive functioning in 45-month-old children.

Prenatal, perinatal, and postnatal factors have been shown to shape neurobiological functioning and alter the risk for mental disorders later in life. The gut microbiome is established early in life, and interacts with the brain via the brain-immune-gut axis. However, little is known about how the microbiome relates to early-life cognitive functioning in children.

Association Between Knee Joint Muscle Activation and Knee Joint Moment Patterns During Walking in Moderate Medial Compartment Knee Osteoarthritis: Implications for Secondary Prevention.

Objective: To determine associations between knee moment features linked to osteoarthritis (OA) progression, gait muscle activation patterns, and strength.

Design: Cross-sectional secondary analysis.

Setting: Gait laboratory.

Does body size impact muscle recruitment during law enforcement physical control simulator use?

This study examined muscle activation during the 'push-pull' component of law enforcement physical abilities testing and assessed activation differences based on sex, height, and body mass index. Fifty participants (40 male) completed the 'push-pull' task while surface electromyograms were recorded from ten upper and lower extremity muscles, and six trunk muscles. Muscle activation was amplitude-normalized to maximum voluntary isometric contraction and compared between sexes and tertiles of height and body mass index (BMI).

The oropharyngeal microbiome is altered in individuals with schizophrenia and mania.

It is being increasingly recognized that human mucosal surfaces are not sterile but are colonized with microorganisms collectively known as the microbiome. The microbiome can alter brain functioning in humans and animals by way of a series of interactions operative in the brain-immune-gut interactome. We characterized the oropharyngeal microbiome in 316 individuals, including 121 with schizophrenia, 62 with mania, 48 with major depressive disorder, and 85 controls without a psychiatric disorder.

Baseline Gait Muscle Activation Patterns Differ for Osteoarthritis Patients Who Undergo Total Knee Arthroplasty Five to Eight Years Later From Those Who Do Not.

Objective: To determine if baseline quadriceps and hamstrings muscle activity patterns differed between those with medial-compartment knee osteoarthritis (OA) who advanced to total knee arthroplasty (TKA) and those who did not advance to TKA, and to examine associations between features extracted from principal component analysis (PCA) and discrete measures.

Methods: Surface electromyograms of the vastus lateralis and medialis, rectus femoris, and lateral and medial hamstrings during walking were collected from 54 individuals with knee OA. Amplitude and temporal characteristics from PCA, co-contraction indices (CCI) for lateral and medial muscle pairs, and root mean square (RMS) amplitudes for early, mid, late, and overall stance were calculated from electromyographic waveforms.

Is Pelvic Floor sEMG a Measure of Women's Sexual Response?

Introduction: Pelvic floor surface electromyography (sEMG) is often used in the assessment and treatment of individuals with pelvic floor abnormalities to measure muscle tone and neural control of the pelvic floor muscles (PFM); however, little is known about the role of the PFM in sexual arousal.

Aim: The aim of this pilot study was to examine whether changes in deep and superficial PFM activity-assessed with sEMG-can be observed during the presentation of sexual stimuli.

Methods: Deep PFM sEMG activity was assessed with a vaginal probe.

Ankle Joint and Rearfoot Biomechanics During Toe-In and Toe-Out Walking in People With Medial Compartment Knee Osteoarthritis.

Background: Toe-in and toe-out walking are 2 strategies that have been shown to be effective in reducing the knee adduction moment in people with knee osteoarthritis. However, despite a positive biomechanical impact on the knee, altering foot rotation may impart unintended forces or joint positions on the ankle that could impact joint health. The kinematic and kinetic changes at the ankle during toe-in or toe-out walking have yet to be examined.

Toe-in and toe-out walking require different lower limb neuromuscular patterns in people with knee osteoarthritis.

Toe-in and toe-out gait modification has received attention lately as a promising treatment for knee osteoarthritis due to its potential to improve knee joint loading and pain. However, the neuromuscular patterns associated with these walking styles are not well known, a factor that may influence knee joint load itself. Our aim was to conduct a thorough examination of the neuromuscular patterns associated with toe-in and toe-out walking in people with knee osteoarthritis.

Differentiating between Affine and Perspective-Based Models for the Geometry of Visual Space Based on Judgments of the Interior Angles of Squares.

This paper attempts to differentiate between two models of visual space. One model suggests that visual space is a simple affine transformation of physical space. The other proposes that it is a transformation of physical space via the laws of perspective.

Clinical and biomechanical changes following a 4-month toe-out gait modification program for people with medial knee osteoarthritis: a randomized controlled trial.

Objective: To compare changes in knee pain, function, and loading following a 4-month progressive walking program with or without toe-out gait modification in people with medial tibiofemoral knee osteoarthritis.

Design: Individuals with medial knee osteoarthritis were randomized to a 4-month program to increase walking activity with (toe-out) or without (progressive walking) concomitant toe-out gait modification. The walking program was similar between the two groups, except that the gait modification group was trained to walk with 15° more toe-out.

Contralateral limb foot rotation during unilateral toe-in or toe-out walking in people with knee osteoarthritis.

Background: Gait modification is a treatment approach often used for a variety of neuromuscular and musculoskeletal pathologies. Gait modification is commonly applied to a single limb, as is done with foot rotation (FR) in people with knee osteoarthritis (KOA). However, the extent to which gait changes observed in the trained limb are also exhibited in the untrained, contralateral limb during a training session is unknown.

Ankle and knee biomechanics during normal walking following ankle plantarflexor fatigue.

The purpose of this study was to investigate the immediate effects of unilateral ankle plantarflexor fatigue on bilateral knee and ankle biomechanics during gait. Lower leg kinematics, kinetics, and muscle activation were assessed before and after an ankle plantarflexor fatiguing protocol in 31 healthy individuals. Fatigue (defined as >10% reduction in maximal isometric ankle plantarflexor torque production and a downward shift in the median power frequency of both heads of the gastrocnemius muscle of the fatigued limb) was achieved in 18 individuals, and only their data were used for analysis purposes.

The Effects of a Heel Wedge on Hip, Pelvis and Trunk Biomechanics During Squatting in Resistance Trained Individuals.

Barbell back squats are a popular exercise for developing lower extremity strength and power. However, this exercise has potential injury risks, particularly to the lumbar spine, pelvis, and hip joint. Previous literature suggests heel wedges as a means of favorably adjusting trunk and pelvis kinematics with the intention of reducing such injury risks.

Lateral wedges with and without custom arch support for people with medial knee osteoarthritis and pronated feet: an exploratory randomized crossover study.

Background: Pronated foot posture is associated with many clinical and biomechanical outcomes unique to medial compartment knee osteoarthritis (OA). Though shoe-worn insole treatment, including lateral wedges, is commonly studied in this patient population, their effects on the specific subgroup of people with medial knee OA and concomitant pronated feet are unknown. The purpose of this study was to evaluate whether lateral wedge insoles with custom arch support are more beneficial than lateral wedge insoles alone for knee and foot symptoms in people with medial tibiofemoral knee osteoarthritis (OA) and pronated feet.

Trunk and lower limb biomechanics during stair climbing in people with and without symptomatic femoroacetabular impingement.

Background: Femoroacetabular impingement is a pathomechanical hip condition leading to pain and impaired physical function. It has been shown that those with femoroacetabular impingement exhibit altered gait characteristics during level walking and stair climbing, and decreased muscle force production during isometric muscle contractions. However, no studies to-date have looked at trunk kinematics or muscle activation during dynamic movements such as stair climbing in this patient population.

The Biomechanical Demands on the Hip During Progressive Stepping Tasks.

Hatfield, GL, Charlton, JM, Cochrane, CK, Hammond, CA, Napier, C, Takacs, J, Krowchuk, NM, and Hunt, MA. The biomechanical demands on the hip during progressive stepping tasks. J Strength Cond Res 31(12): 3444-3453, 2017-Functional hip strengthening exercises are important components of lower extremity (LE) rehabilitation and include single-leg squats (SLS), step-downs (SD), and step-ups (SU).

Knee and ankle biomechanics with lateral wedges with and without a custom arch support in those with medial knee osteoarthritis and flat feet.

Unlabelled: This study compared immediate changes in knee and ankle/subtalar biomechanics with lateral wedge orthotics with and without custom arch support in people with knee osteoarthritis and flat feet. Twenty-six participants with radiographic evidence of medial knee osteoarthritis (22 females; age 64.0 years [SD 8.

The Silent Sway of Splicing by Synonymous Substitutions.

Alternative splicing diversifies mRNA transcripts in human cells. This sequence-driven process can be influenced greatly by mutations, even those that do not change the protein coding potential of the transcript. Synonymous mutations have been shown to alter gene expression through modulation of splicing, mRNA stability, and translation.

Relationship between knee adduction moment patterns extracted using principal component analysis and discrete measures with different amplitude normalizations: Implications for knee osteoarthritis progression studies.

Background: Knee adduction moment discrete features (peaks and impulses) are commonly reported in knee osteoarthritis gait studies, but they do not necessarily capture loading patterns. Principal component analysis extracts dynamic patterns, but can be difficult to interpret. This methodological study determined relationships between external knee adduction moment discrete measures and principal component analysis features, and examined whether amplitude-normalization methods influenced differences in those with knee osteoarthritis who progressed to surgery versus those that did not.