Publications by authors named "Hasselbach H"

The amino acid L-methionine is an essential amino acid and is commonly used as a feed supplement in terrestrial animals. It is less suitable for marine organisms because it is readily excreted. It is also highly water soluble and this results in loss of the feed and eutrophication of the water.

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Article Synopsis
  • Primary myelofibrosis is a condition involving abnormal blood cell production, characterized by issues such as dysfunctional megakaryocytes and changes in bone marrow and spleen structure.
  • The study focuses on the role of CD9, a protein that impacts megakaryocyte formation and interactions with the bone marrow environment, finding that its deregulation is linked to the severity of the disease.
  • Results indicate that CD9 influences both the abnormal behaviors of megakaryocytes in primary myelofibrosis and their interactions with stromal cells, supporting a theory that poor cell interaction contributes to the disease's progression.
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Background: Histological findings of choroidal melanomas after proton beam irradiation have been reported for complicated cases after enucleation. We present specimens of a tumor after transretinal probe excision.

Patient And Methods: One year after irradiation, the biopsy was examined histologically.

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Aims: To evaluate the changes of morphological and functional characteristics of the retinal pigment epithelium (RPE)-choroid perfusion culture during cultivation.

Methods: PorcineRPE-choroid tissue was cultivated in a perfusion tissue culture system. After the indicated times, histology, immunolocalization of collagen IV and von Willebrand factor, RPE cell viability with calcein-AM, TUNEL assay and occludin immunolocalization of RPE cells were examined.

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Objective: The aim was to determine systemic risk factors for acute central retinal artery occlusion (CRAO) and central retinal vein occlusion (CRVO) and to evaluate the usefulness of systemic diagnostics in CRAO and CRVO.

Methods: The study consisted of a retrospective chart review including 80 patients (CRAO 38, CRVO 42). All patients underwent systemic diagnostics including blood pressure measurement, blood cholesterol level, carotid Doppler imaging, transthoracic echocardiography (TTE), intraocular pressure measurement, glaucoma history and presence of thrombophilic factors.

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Radial optic neurotomy (RON) has been proposed for alleviation of the "scleral outlet compartment syndrome" at the level of the lamina cribrosa, which is thought to play a pathoetiologic role in central retinal vein occlusion (CRVO). The aim of this study has been to analyze the ultrastructural alterations of the lamina cribrosa after RON to gain new insights in the underlying pathomechanical factors. Fifteen donor eyes underwent a standardized open-sky-vitrectomy and RON after removal of the anterior eye segment for keratoplasty.

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Background: Necrotising retinopathy in immunocompromised hosts is characterised by an unfavourable course often with unspecific clinical features. Therefore, differential diagnosis can be critical.

History And Signs: A case of an initially therapy-resistant, necrotizing retinopathy is presented in a 65-year-old immunocompromised male patient suffering from chronic B-cell leukemia.

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Background: To evaluate the potential role of radial optic neurotomy (RON), a new surgical technique has been recently proposed for treating central retinal vein occlusion (CRVO). It is hypothesized that CRVO constitutes a neurovascular compartment syndrome at the site of the lamina cribrosa, which can be alleviated by performing a radial incision at the nasal part of the optic nerve head, relaxing the cribriform plate and the adjacent sclera.

Methods: One hundred and seven patients were treated with RON for CRVO at five collaborating ophthalmologic centers.

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Small unilamellar phosphatidylcholine vesicles, formed by solubilizing phosphatidylcholine with sodium cholate and removing the detergent by gel filtration, have been studied in their interaction with phospholipid exchange protein. The exchange of phosphatidylcholine between the vesicles and erythrocyte ghosts was greatly stimulated by the phosphatidylcholine-specific exchange protein from bovine liver. It was found that 95% of the phosphatidylcholine was readily available for exchange within 3 h at 37 degrees C.

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