Stabilizing A Vascularized Autologous Matrix with Flexible Magnesium Scaffolds to Reconstruct Dysfunctional Left Ventricular Myocardium in a Large-Animal Feasibility Study.

The surgical reconstruction of dysfunctional myocardium is necessary for patients with severe heart failure. Autologous biomaterials, such as vascularized patch materials, have a regenerative potential due to in vivo remodeling. However, additional temporary mechanical stabilization of the biomaterials is required to prevent aneurysms or rupture.

Investigations into Flux-Free Plasma Brazing of Aluminum in a Local XHV-Atmosphere.

As a lightweight construction material, aluminum plays a key role in weight reduction and, thus, sustainability in the transport industry. The brazing of aluminum and its alloys is impeded by the natural passivating oxide layer, which interferes with the brazing process. The presented study investigates the possibility of using a thermal silane-doped argon plasma to reduce this oxide layer in situ and thus eliminating the need to use hazardous chemical fluxes to enable high-quality brazing.

Screening for Behavioral Health Patient Aggression in Emergency Departments to Reduce Workplace Violence.

Introduction: Patient violence in health care facilities occurs daily. Structured risk assessments, when regularly completed, have been effective in prompting interventions to reduce aggression in Behavioral Health (BH) settings.

Methods: This quasi-experimental study evaluated the effectiveness of the Dynamic Appraisal of Situational Aggression - Inpatient Version (DASA) validated screening tool to reduce aggressive outbursts in an emergency department (ED) setting with BH patients awaiting transfer to a psychiatric facility.

Induction Heating in Underwater Wet Welding-Thermal Input, Microstructure and Diffusible Hydrogen Content.

Hydrogen-assisted cracking is a major challenge in underwater wet welding of high-strength steels with a carbon equivalent larger than 0.4 wt%. In dry welding processes, post-weld heat treatment can reduce the hardness in the heat-affected zone while simultaneously lowering the diffusible hydrogen concentration in the weldment.

Pressure-compacted and spider silk-reinforced fibrin demonstrates sufficient biomechanical stability as cardiac patch in vitro.

Objective: The generation of bio-/hemocompatible cardiovascular patches with sufficient stability and regenerative potential remains an unmet goal. Thus, the aim of this study was the generation and biomechanical evaluation of a novel cardiovascular patch composed of pressure-compacted fibrin with embedded spider silk cocoons.

Methods: Fibrin-based patches were cast in a customized circular mold.

The Applicability of the Standard DIN EN ISO 3690 for the Analysis of Diffusible Hydrogen Content in Underwater Wet Welding.

The European standard ISO 3690 regulates the measurement of diffusible hydrogen in arc-welded metal. It was designed for different welding methods performed in dry atmosphere (20% humidity). Some details of the standard are not applicable for wet underwater welding.

Investigation of the Prediction Accuracy of a Finite Element Analysis Model for the Coating Thickness in Cross-Wedge Rolled Coaxial Hybrid Parts.

The Collaborative Research Centre 1153 (CRC 1153) "Process chain for the production of hybrid high-performance components through tailored forming" aims to develop new process chains for the production of hybrid bulk components using joined semi-finished workpieces. The subproject B1 investigates the formability of hybrid parts using cross-wedge rolling. This study investigates the reduction of the coating thickness of coaxially arranged semi-finished hybrid parts through cross-wedge rolling.

Evaluating policy responses to noncommunicable diseases in seven Caribbean countries: challenges to addressing unhealthy diets and physical inactivity.

Objective: To identify, assess, and compare existing policies on noncommunicable diseases (NCDs) in the Caribbean, gaps in policy responses, and the factors influencing successful policy development and implementation following the Port of Spain Declaration of 2007. Specifically, to examine policies that target the upstream determinants of two NCD risk factors-unhealthy diets and physical inactivity.

Methods: A total of 76 semi-structured interviews with 80 relevant stakeholders in government, the private sector, and civil society were complemented by policy document analysis.

Engineering of biodegradable magnesium alloy scaffolds to stabilize biological myocardial grafts.

Objective: Regenerative bioprostheses are being investigated for replacement of dysfunctional myocardium worldwide. The aim of this study was to develop a degradable magnesium structure to mechanically support the delicate biological grafts during the early remodeling phase.

Methods: Sheets of magnesium alloys (LA33, LA63 and AX30) were manufactured into scaffolds by abrasive water jet cutting.

Impact of intraprosthetic drilling on the strength of the femoral stem in periprosthetic fractures: A finite element investigation.

Treatment of periprosthetic femur fractures after total hip arthroplasty remains a major challenge in orthopedic surgery. Recently, a novel surgical technique using intraprosthetic screw fixation has been suggested. The purpose of this study was to evaluate the influence of drilling the femoral hip stem on integrity and strength of the implant.

In vitro and in vivo corrosion properties of new iron-manganese alloys designed for cardiovascular applications.

The principle of biodegradation for the production of temporary implant materials (e.g. stents) plays an important role in the treatment of congenital heart defects.

Geometric adaption of biodegradable magnesium alloy scaffolds to stabilise biological myocardial grafts. Part I.

Synthetic patch materials currently in use have major limitations, such as high susceptibility to infections and lack of contractility. Biological grafts are a novel approach to overcome these limitations, but do not always offer sufficient mechanical durability in early stages after implantation. Therefore, a stabilising structure based on resorbable magnesium alloys could support the biological graft until its physiologic remodelling.

Intraprosthetic screw fixation increases primary fixation stability in periprosthetic fractures of the femur - a biomechanical study.

Background: The purpose of this study was to develop a new fixation technique for the treatment of periprosthetic fractures using intraprosthetic screw fixation. The goal was to biomechanically evaluate the increase in primary fixation stability compared to unicortical locked-screw plating.

Methods: A Vancouver C periprosthetic fracture was simulated in femur prosthesis constructs.

In vivo degradation of magnesium alloy LA63 scaffolds for temporary stabilization of biological myocardial grafts in a swine model.

Synthetic or biological patch materials used for surgical myocardial reconstruction are often fragile. Therefore, a transient support by degradable magnesium scaffolds can reduce the risk of dilation or rupture of the patch until physiological remodeling has led to a sufficient mechanical durability. However, there is evidence that magnesium implants can influence the growth and physiological behavior of the host's cells and tissue.

Different thermal conductivity in drilling of cemented compared with cementless hip prostheses in the treatment of periprosthetic fractures of the proximal femur: an experimental biomechanical analysis.

Purpose: The purpose of this study was to evaluate the different temperature levels whilst drilling cemented and cementless hip prostheses implanted in bovine femora, and to evaluate the insulating function of the cement layer.

Methods: Standard hip prostheses were implanted in bovine donor diaphyses, with or without a cement layer. Drilling was then performed using high-performance-cutting drills with a reinforced core, a drilling diameter of 5.

Temperature control with internally applied cooling in solid material drilling: an experimental, biomechanical study.

Purpose: The purpose of this study was to evaluate the different temperature levels while drilling solid materials and to compare different cooling solutions for possible temperature control. An additional purpose was to develop an internal cooling device which can be connected to routinely used manual drilling devices in trauma surgery.

Methods: Drilling was performed on a straight hip stem implanted in bovine femora without cooling, with externally applied cooling and with a newly developed internal cooling device.

Intraprosthetic fixation techniques in the treatment of periprosthetic fractures-A biomechanical study.

Aim: To develop new fixation techniques for the treatment of periprosthetic fractures using intraprosthetic screw fixation with inserted threaded liners.

Methods: A Vancouver B1 periprosthetic fracture was simulated in femur prosthesis constructs using sawbones and cemented regular straight hip stems. Fixation was then performed with either unicortical locked-screw plating using the less invasive stabilization system-plate or with intraprosthetic screw fixation using inserted liners.

Biocompatibility of fluoride-coated magnesium-calcium alloys with optimized degradation kinetics in a subcutaneous mouse model.

The principle of biodegradation has been considered for many years in the development of cardiovascular stents, especially for patients with congenital heart defects. A variety of materials have been examined with regard to their suitability for cardiovascular devices. Iron- and magnesium-based stents were investigated intensively during the last years.

Novel Repair Concept for Composite Materials by Repetitive Geometrical Interlock Elements.

Material adapted repair technologies for fiber-reinforced polymers with thermosetting matrix systems are currently characterized by requiring major efforts for repair preparation and accomplishment in all industrial areas of application. In order to allow for a uniform distribution of material and geometrical parameters over the repair zone, a novel composite interlock repair concept is introduced, which is based on a repair zone with undercuts prepared by water-jet technology. The presented numerical and experimental sensitivity analyses make a contribution to the systematic development of the interlock repair technology with respect to material and geometrical factors of influence.

Low-temperature degradation of different zirconia ceramics for dental applications.

The aim of this investigation was to determine the influence of simulated ageing on the tetragonal-to-monoclinic phase transformation and on the flexural strength of a 3Y-TZP ceramic, compared to alumina toughened zirconia (ATZ) and ceria-stabilized zirconia (12Ce-TZP). Standardized disc specimens of each material were hydrothermally aged in steam at 134°C and 3bar for 0, 16, 32, 64 or 128h. The phase transformation was determined by X-ray diffraction (XRD) and atomic force microscopy.