Femtosecond laser assisted selective etching of microchannels in lithium niobate.

Here, we report on the fabrication of cm-long microchannels in LiNbO by selective etching of femtosecond laser inscribed tracks using hydrofluoric acid. We achieved a 1 cm long microchannel after 300 h of etching a single track inscribed into the volume along the optical axis of LiNbO. Furthermore, we investigated the dependence of the etching behavior on various writing parameters.

PLASMA CONCENTRATION AND PHARMACODYNAMICS OF INTRAMUSCULAR ADMINISTRATION OF ALFAXALONE IN INDIAN PEAFOWL ().

Alfaxalone, a neuroactive steroid with anesthetic properties, is considered safe when used alone or in combination with other drugs for anesthesia at recommended species doses, and its use has been studied in numerous species. The objective of this study was to assess the pharmacokinetics and pharmacodynamics of IM alfaxalone in Indian peafowl (; hereafter peafowl). Eight female peafowl from one zoological institution were used.

The influence of maternal psychological distress on the mode of birth and duration of labor: findings from the FinnBrain Birth Cohort Study.

Antepartum depression, general anxiety symptoms, and pregnancy-related anxiety have been recognized to affect pregnancy outcomes. Systematic reviews on these associations lack consistent findings, which is why further research is required. We examined the associations between psychological distress, mode of birth, epidural analgesia, and duration of labor.

FATAL IN A LESSER SPOT-NOSED GUENON ().

A 4-yr-old male intact lesser spot-nosed guenon (), housed at a North American zoological facility, presented with acute lethargy, inappetence, and mild neurologic signs. Physical examination revealed hemorrhagic pleural effusion in the right hemithorax. This guenon's condition improved over several days but then deteriorated, and the guenon presented with lethargy and weakness.

µJ-level multi-cycle terahertz generation in a periodically poled Rb:KTP crystal.

We demonstrate multi-cycle terahertz (MC-THz) generation in a 15.5 mm long periodically poled rubidium (Rb)-doped potassium titanyl phosphate (Rb:PPKTP) crystal with a poling period of 300 µm. By cryogenically cooling the crystal to 77 K, up to 0.

Use of Receiver Operating Curve Analysis and Machine Learning With an Independent Dose Calculation System Reduces the Number of Physical Dose Measurements Required for Patient-Specific Quality Assurance.

Purpose: Our purpose was to assess the use of machine learning methods and Mobius 3D (M3D) dose calculation software to reduce the number of physical ion chamber (IC) dose measurements required for patient-specific quality assurance during corona virus disease 2019.

Methods And Materials: In this study, 1464 inversely planned treatments using Pinnacle or Raystation treatment planning software (TPS) were delivered using Elekta Versa HD and Varian Truebeam and Truebeam STx linear accelerators between June 2018 and November 2019. For each plan, an independent dose calculation was performed using M3D, and an absolute dose measurement was taken using a Pinpoint IC inside the Mobius phantom.

MHz-repetition rate fs-laser-inscribed crystalline waveguide lasers inscribed at 100 mm/s: erratum.

We present an erratum concerning the repetition rate of the fs-laser system used for the inscription of the waveguides stated in our paper [Opt. Express 28, 12011-12019 (2020)]. The Fidelity HP High Energy laser supplied by Coherent Inc.

A quantitative analysis of biomechanical lung model consistency using 5DCT datasets.

Purpose: Lung biomechanical models are important for understanding and characterizing lung anatomy and physiology. A key parameter of biomechanical modeling is the underlying tissue elasticity distribution. While human lung elasticity estimations do not have ground truths, model consistency checks can and should be employed to gauge the stability of the estimation techniques.

An adversarial machine learning framework and biomechanical model-guided approach for computing 3D lung tissue elasticity from end-expiration 3DCT.

Purpose: Lung elastography aims at measuring the lung parenchymal tissue elasticity for applications ranging from diagnostic purposes to biomechanically guided deformations. Characterizing the lung tissue elasticity requires four-dimensional (4D) lung motion as an input, which is currently estimated by deformably registering 4D computed tomography (4DCT) datasets. Since 4DCT imaging is widely used only in a radiotherapy treatment setup, there is a need to predict the elasticity distribution in the absence of 4D imaging for applications within and outside of radiotherapy domain.

MHz-repetition rate fs-laser-inscribed crystalline waveguide lasers inscribed at 100 mm/s.

We report on fast direct laser inscription of waveguide laser structures in a crystal. For the first time, a 1 MHz-repetition rate fs-laser was utilized for this purpose. We inscribed and characterized more than 100 tracks with different inscription parameters in Yb:CALGO crystals.

SEDATIVE, CARDIORESPIRATORY, AND THERMOREGULATORY EFFECTS OF ALFAXALONE ON BUDGERIGARS ().

Alfaxalone is a neurosteroid anesthetic agent that has been extensively used in both human and veterinary medicine for more than 50 yr. Previous studies involving avian species demonstrated various dose ranges and multiple routes of administration. The aim of this study was to evaluate the short-term sedative, cardiorespiratory, and thermoregulatory effects of an intramuscular injection of alfaxalone on budgerigars ().

Systematic feasibility analysis of performing elastography using reduced dose CT lung image pairs.

Purpose: Elastography using computer tomography (CT) is a promising methodology that can provide patient-specific regional distributions of lung biomechanical properties. The purpose of this paper is to investigate the feasibility of performing elastography using simulated lower dose CT scans.

Methods: A cohort of eight patient CT image pairs were acquired with a tube current-time product of 40 mAs for estimating baseline lung elastography results.

Safety-oriented design of in-house software for new techniques: A case study using a model-based 4DCT protocol.

Purpose: In-house software is commonly employed to implement new imaging and therapy techniques before commercial solutions are available. Risk analysis methods, as detailed in the TG-100 report of the American Association of Physicists in Medicine, provide a framework for quality management of processes but offer little guidance on software design. In this work, we examine a novel model-based four-dimensional computed tomography (4DCT) protocol using the TG-100 approach and describe two additional methods for promoting safety of the associated in-house software.

Feasibility of deriving a novel imaging biomarker based on patient-specific lung elasticity for characterizing the degree of COPD in lung SBRT patients.

Objective:: Lung tissue elasticity is an effective spatial representation for Chronic Obstructive Pulmonary Disease phenotypes and pathophysiology. We investigated a novel imaging biomarker based on the voxel-by-voxel distribution of lung tissue elasticity. Our approach combines imaging and biomechanical modeling to characterize tissue elasticity.

Estimation and validation of patient-specific high-resolution lung elasticity derived from 4DCT.

Purpose: Lung diseases are commonly associated with changes in lung tissue's biomechanical properties. Functional imaging techniques, such as elastography, have shown great promise in measuring tissue's biomechanical properties, which could expand the utility and effectiveness of radiotherapy treatment planning. We present a novel methodology for characterizing a key biomechanical property, parenchymal elasticity, derived solely from 4DCT datasets.

Highly efficient Q-switched Yb:YAG channel waveguide laser with 5.6 W of average output power.

In this Letter, we present high-power continuous wave (CW) and Q-switched femtosecond laser-written Yb:YAG channel waveguide lasers. In Q-switched operation, obtained by a semiconductor saturable absorber mirror (SESAM), as well as in CW operation, the laser generates average output powers of more than 5.6 W and reaches slope efficiencies above 74%.

Systematic feasibility analysis of a quantitative elasticity estimation for breast anatomy using supine/prone patient postures.

Purpose: Breast elastography is a critical tool for improving the targeted radiotherapy treatment of breast tumors. Current breast radiotherapy imaging protocols only involve prone and supine CT scans. There is a lack of knowledge on the quantitative accuracy with which breast elasticity can be systematically measured using only prone and supine CT datasets.

The sweetest thing: the influence of angularity, symmetry, and the number of elements on shape-valence and shape-taste matches.

A within-participants experiment was conducted in two countries (the UK and Colombia) in order to investigate the matching of shapes to taste words. Comparing the two countries allowed us to explore some of the cultural differences that have been reported thus far solely in terms of people's visual preferences. In particular, we addressed the question of whether properties other than angularity influence shape-valence and shape-taste matching (crossmodal correspondences).

Efficient Yb³⁺:CaGdAlO₄ bulk and femtosecond-laser-written waveguide lasers.

We report on, to the best of our knowledge, the first fs-laser-written waveguide laser in Yb3+:CaGdAlO4 (Yb:CALGO). With Yb:CALGO crystals grown in our labs, we obtained a slope efficiency of 69% and up to 2.4 W of continuous wave (cw) output power in a waveguide-laser configuration.

Continuous-wave Pr³⁺:BaY₂F₈ and Pr³⁺:LiYF₄ lasers in the cyan-blue spectral region.

We report on the first, to the best of our knowledge, continuous-wave quasi three-level lasers emitting in the cyan-blue spectral range in praseodymium-doped crystalline materials. Applying Pr(3+):BaY2F8 as an active medium, up to 201 mW of output power at 495 nm could be obtained with a slope efficiency of 27% under pumping with an optically pumped semiconductor laser (2ω-OPSL) at 480 nm. In the same pumping scheme using Pr(3+):LiYF4, output powers up to 70 mW were realized at 491 and 500 nm, respectively.

[Clinical efficacy and safety of emergent percutaneous coronary intervention for vein-grafts in the patients with acute myocardial infarction: comparison between age groups].

Objective: To evaluate the efficacy and the safety of emergent primary percutaneous coronary intervention (PCI) in the saphenous vein bypass graft (SVBG) of acute myocardial infarction (AMI), and compare the results between aged -patients with non-aged patients.

Methods: Three hundred and nine consecutive AMI patients with culprit SVBG vessels, were analysed, including aged patients 213 cases(>or=70 years old), non-aged patients 96 cases(<70 years old), underwent the emergent primary PCI after confirmed below TIMI III perfusion(TIMI 0-TIMI II) in coronary angiographies. The immediate results and in-hospital outcomes were compared between two groups.

Variant amino acids in the extracellular loops of murine and human vasopressin V2 receptors account for differences in cell surface expression and ligand affinity.

Cloning and sequencing of the murine chromosomal region XB harboring the murine vasopressin V(2) receptor (mV(2)R) gene and comparison with the orthologous human Xq28 region harboring the human vasopressin V(2) receptor (hV(2)R) revealed conservation of the genomic organization and a high degree of sequence identity in the V(2)R coding regions. Despite an identity of 87% of the amino acid sequences, both receptors show marked functional differences upon stable expression in Chinese hamster ovary cells: the mV(2)R displayed a 5-fold higher affinity for [(3)H]AVP than the human ortholog; similar differences were found for the AVP-mediated activation of adenylyl cyclase. Saturation binding experiments with transiently transfected intact COS.