Publications by authors named "Hasse B"
Among 3127 episodes of suspected infective endocarditis, the 2023 Duke-International Society for Cardiovascular Infectious Diseases clinical criteria showed an accuracy of 90% for infective endocarditis diagnosis. A new heart murmur was present in 690 (22%) episodes. Excluding imaging and surgical findings decreased the accuracy to 73%, while using the physical examination criterion slightly improved the accuracy to 78%.
View Article and Find Full Text PDFArticle Synopsis
- - The study aimed to assess improvements in health-related quality of life, as measured by the Short Form-36 (SF-36) scores, for patients in a Swiss Outpatient Parenteral Antimicrobial Therapy (OPAT) program from before discharge to 7-14 days after discharge.
- - It involved a cohort of 33 patients from a public hospital in Switzerland, who completed a shortened version of the SF-36 questionnaire and additional questions on satisfaction at two different times.
- - Results indicated significant improvements in three out of four domains (emotional role, social functioning, emotional well-being) and a high patient satisfaction rate, suggesting OPAT programs positively impact patients' health-related quality of life.
Background: Mycobacterium chelonae is a rare cause of infective endocarditis that is difficult to diagnose and treat. After we found M chelonae in a series of patients, we aimed to investigate its role in cardiovascular prosthesis dysfunction and contamination of bioprostheses as a possible cause of infection.
Methods: In this collaborative microbiological study, we report on nine patients treated in three cardiovascular surgical departments in Germany, who were found to have M chelonae infection after receiving BioIntegral bioprostheses.
Article Synopsis
- The study examines the relationship between oral bacteria and infective endocarditis (IE), highlighting the shift in antibiotic prophylaxis (AP) guidelines in 2007/2008 that limited AP to high-risk patients only.
- Researchers analyzed data from University Hospital Zurich (2000-2022) to determine if oral streptococcal IE cases rose in moderate-risk patients following these guideline changes.
- Results showed that moderate-risk patients had a significantly higher risk of oral streptococcal IE after the guidelines were updated, suggesting that expanding AP to include certain moderate-risk groups, particularly those with congenital valve anomalies, may be necessary.*
Article Synopsis
- A study involving 302 cases of prosthetic valve endocarditis (PVE) showed a one-year mortality rate of 31%.
- Early-onset PVE (within 6 months of valve surgery) did not result in worse outcomes compared to late-onset PVE, with mortality rates of 21% versus 32% (p=0.126).
- Both early and late-onset categories required similar rates of redo valve surgeries.
Article Synopsis
- Diagnosing infective endocarditis (IE) is complex, and this study compared the effectiveness of the 2015 and 2023 Duke clinical criteria for diagnosing the condition.
- Conducted in two Swiss University Hospitals, researchers analyzed data from 3127 patients suspected of having IE, with 1177 confirmed cases, to assess the agreement between the clinical criteria and expert diagnoses.
- Results showed that the 2023 criteria had a higher sensitivity (69%) compared to the 2015 criteria (59%), although both versions categorized about one-third of episodes as possible IE.
Background: Bivalent messenger RNA (mRNA) vaccines, designed to combat emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants, incorporate ancestral strains and a new variant. Our study assessed the immune response in previously vaccinated individuals of the Swiss HIV Cohort Study (SHCS) and the Swiss Transplant Cohort Study (STCS) following bivalent mRNA vaccination.
Methods: Eligible SHCS and STCS participants received approved bivalent mRNA SARS-CoV-2 vaccines (mRNA-1273.
Background: To identify 18F-fluorodeoxyglucose (FDG) uptake patterns in positron emission tomography/computed tomography (PET/CT) caused by infection, inflammation, surgical material, and/or graft coating.
Methods And Results: Of 610 consecutive patients with thoracic aortic graft surgery, 60 patients with 187 PET/CT were retrospectively included. We quantified FDG uptake in all grafts using maximum standardized uptake value (SUVmax) alone and in relation to liver background (SUVratio) and determined the uptake pattern.
Article Synopsis
- The study focuses on the effectiveness of outpatient parenteral antimicrobial therapy (OPAT) and its role in antimicrobial stewardship (AMS) at the University Hospital of Zurich from November 2018 to September 2022.
- It analyzed 303 OPAT assignments, with 260 leading to effective treatment; significant cost savings of approximately 9.8 million CHF were achieved by reducing in-hospital stays, while maintaining patient safety and a 77% clinical cure rate.
- The findings suggest that integrating OPAT within AMS enhances patient care and hospital efficiency, with minimal adverse events and readmissions linked to the treatment.
Optimizing antibiotic therapy is imperative with rising bacterial resistance and high infection mortality. Extended infusion defined as a continuous infusion (COI) or prolonged infusion (PI) of beta-lactams and glycopeptides might improve efficacy and safety compared to their intermittent administration (IA). This study aimed to evaluate the efficacy and safety of extended infusion in pediatric patients.
View Article and Find Full Text PDFArticle Synopsis
- The study assessed the diagnostic effectiveness of the Duke-ISCVID 2023 criteria for infective endocarditis (IE) against earlier versions from 2000 and 2015.
- Conducted at two university hospitals between 2014 and 2022, it involved 2132 patients, 1101 of whom were confirmed to have IE.
- Results showed the new criteria improved sensitivity to 84% (up from 70%) but decreased specificity to 60% (down from 74%), suggesting a need for further refinements to balance these diagnostic metrics.
Article Synopsis
- The Duke criteria for diagnosing infective endocarditis were updated in 2023, and this study evaluates their diagnostic accuracy, particularly for patients with Staphylococcus aureus bacteremia (SAB).
- Analyzing data from 1344 SAB episodes, the revised 2023 criteria showed improved sensitivity (81% for Duke-ISCVID and 82% for Duke-ESC) compared to the 2015 version (75%), although specificity decreased from 99% to 96%.
- The study highlights that while spondylodiscitis was more common in patients with SAIE, this trend was not significant when certain criteria were excluded, indicating the need for further research on the new criteria's components.
Background: After basic immunization with 2 mRNA SARS-CoV-2 vaccine doses, only a small proportion of patients who are severely immunocompromised generate a sufficient antibody response. Hence, we assessed the additional benefit of a third SARS-CoV-2 vaccine in patients with different levels of immunosuppression.
Methods: In this observational extension of the COVERALL trial (Corona Vaccine Trial Platform), we recruited patients from the Swiss HIV Cohort Study and the Swiss Transplant Cohort Study (ie, lung and kidney transplant recipients).
Objectives: This study aimed to investigate the association of demographic and clinical characteristics, including HIV-specific parameters with the antibody response to a third dose of a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA vaccine in people with HIV-1 (PWH).
Design: Post hoc analysis of data collected during the observational extension of the COrona VaccinE tRiAL pLatform trial (COVERALL-2) nested into the Swiss HIV Cohort Study (SHCS).
Methods: Serological measurements were conducted on a total of 439 PWH who had received a third dose of either mRNA-1273 (Moderna) or BNT162b2 (Pfizer-BioNTech) SARS-CoV-2 vaccine.
Introduction: Around 25% of patients with left-sided infective endocarditis and operative indication do not undergo surgery. Baseline characteristics and outcomes are underreported. This study describes characteristics and outcomes of surgical candidates with surgical intervention or medical treatment only.
View Article and Find Full Text PDFStaphylococcus aureus carriage is a risk factor for invasive infections. Unique genetic elements favoring the transition from colonizing to invasive phenotype have not yet been identified, and phenotypic adaptation traits are understudied. We therefore assessed phenotypic and genotypic profiles of 11 S.
View Article and Find Full Text PDFBackground: Bone mineral density (BMD) loss may be accelerated in people with HIV (PLWH). It is unknown whether a polygenic risk score (PRS) is associated with low BMD in PLWH.
Methods: Swiss HIV Cohort Study participants of self-reported European descent underwent ≥2 per-protocol dual x-ray absorptiometry (DXA) measurements ≥2 years apart (2011-2020).
Aims Of The Study: The goal of this descriptive study was to assess the performance as well as the extent of the clinical impact of rapid automated antimicrobial susceptibility testing in patients with bacteraemia due to Enterobacterales. We also aimed to analyse how rapid automated antimicrobial susceptibility testing influences clinical decision-making.
Methods: This single-centre study conducted at the University Hospital of Zurich included data from all consecutive patients with Enterobacterales bacteraemia from November 2019 to October 2020.
Article Synopsis
- The 2023 Duke-ISCVID IE Criteria update new diagnostic methods and imaging techniques for infective endocarditis, reflecting advancements in microbiology and epidemiology since the original guidelines were published in 1994 and modified in 2000.* -
- Key changes include new tests for detecting specific bacteria, the introduction of intraoperative inspection as a major criterion, and an expanded list of microorganisms considered typical for IE, especially with certain heart implants.* -
- Additionally, the updated criteria simplify blood culture requirements and emphasize the need for ongoing updates to these guidelines, proposing that they be maintained as a "Living Document" for continued relevance.*
Article Synopsis
- The extended COVERALL trial demonstrated that a third dose of the Moderna mRNA-1273 vaccine produced a similar antibody response to the Pfizer-BioNTech BNT162b2 vaccine in participants with varying levels of immunosuppression.
- The measured effectiveness was 95.3% for Moderna and 98.1% for Pfizer, showing both vaccines are highly effective.
- The statistical analysis indicated that the difference in effectiveness between the two vaccines was minimal, with a -2.8% difference, suggesting noninferiority of the Moderna vaccine.
Article Synopsis
- Heart transplantation (HT) can be a last resort for patients with severe infective endocarditis (IE) and significant heart issues, as shown in a study involving 20 patients across several countries from 1991 to 2021.
- The study found that the average age of these patients was 50, with a mix of native and prosthetic valve infections primarily affecting aortic and mitral valves; patients experienced major complications like heart failure and abscesses.
- Despite a 35% mortality rate, particularly in the first month post-transplant, most patients who survived the hospital stay did well after 35.5 months of follow-up, indicating that HT can be a viable option for select individuals with persistent IE.
Objective: People with HIV (PWH) have a higher risk of type 2 diabetes (T2D) than HIV-negative individuals. In the general population, diabetes risk scores are used to identify persons at risk of developing T2D, but little is known regarding their performance in PWH.
Design: Assessment of the capacity of five diabetes risk scores to predict T2D in PWH.
Aims Of The Study: Numerous studies from different countries have contributed to an improved understanding of blood culture-negative infective endocarditis. However, little is known about its epidemiology and microbiology in Switzerland. We aimed to assess the epidemiology and microbiology of blood culture-negative endocarditis at the University Hospital Zurich, Switzerland.
View Article and Find Full Text PDFBackground: Colonization with Mycobacterium chimaera and other non-tuberculous mycobacteria (NTM) has been reported for heater-cooler devices (HCDs) produced by several manufacturers. Up until now, exclusively LivaNova (London, UK) HCDs have been associated with M. chimaera infections after cardiac surgery.
View Article and Find Full Text PDF