Background And Aim: is a highly contagious zoonotic bacterial micro-organism. This study aimed to estimate the prevalence of in dogs using serological and molecular methods. Furthermore, a sequencing analysis of dog isolates was conducted.
View Article and Find Full Text PDFThe current manuscript presents a mathematical model of dengue fever transmission with an asymptomatic compartment to capture infection dynamics in the presence of uncertainty. The model is fuzzified using triangular fuzzy numbers (TFNs) approach. The obtained fuzzy-fractional dengue model is then solved and analyzed through fuzzy extension of modified residual power series algorithm, which utilizes residual power series along with Laplace transform.
View Article and Find Full Text PDFHydration dynamics and solvent viscosity play critical roles in the structure and function of biomolecules. An overwhelming body of evidence suggests that protein and membrane fluctuations are closely linked to solvent fluctuations. While extensive research exists on the use of vibrational probes to detect local interactions and solvent dynamics, fewer studies have explored how the behavior of these reporters changes in response to bulk viscosity.
View Article and Find Full Text PDFBackground: A versatile ultra-high performance liquid chromatography method with diode array detection was developed to quantify a wide range of antibiotics in human serum. This method addresses the need for rapid and accurate determination of antibiotic levels to ensure effective patient treatment and support the fight against antibiotic resistance.
Methods: This method assesses 31 different compounds covering β-lactams, fluoroquinolones, antifungals, antituberculars, and more.
Introduction: Ectopic pregnancies are a significant clinical concern, with 90 % occurring in the fallopian tubes. However, they can also manifest in other locations, including the cervix, ovary, and abdominal cavity. Abdominal pregnancies, which constitute less than 1 % of ectopic pregnancies, are associated with considerable morbidity and mortality.
View Article and Find Full Text PDFAims: The accuracy of model-informed precision dosing largely depends on selecting the most appropriate population pharmacokinetic (popPK) model from many available options. This study aims to evaluate the concordance of optimal initial simulated doses among various vancomycin popPK models developed in neonates and to explore the role of predictive performance in explaining the variability in probability of target attainment (PTA).
Methods: A virtual neonatal patient population was created and 26 previously externally evaluated vancomycin popPK models were used to simulate 5 different dosing regimens.
Managing floods in interconnected nonurban and urban areas of arid regions prone to flash floods requires a more dynamic and integrated approach than traditional linear methods. In this regard, this study proposes a novel multi-stage decision-making framework which reshapes the traditional cascade approach to flood management by addressing the interdependencies between upstream and downstream regions. The proposed cyclic decision-making process involves five main steps: First, the Hydraulic and Hydrological (H/H) conditions in urban and nonurban areas were modeled using the SWMM.
View Article and Find Full Text PDFIntroduction: Guidelines for vancomycin therapeutic monitoring recommend using a Bayesian approach with a population pharmacokinetic model to estimate the 24 h area under the concentration-time curve over first-order equations. Thus, we performed an external evaluation of population pharmacokinetic models of vancomycin in neonates and compared Bayesian results with those observed in clinical practice via pharmacokinetic equations to improve therapeutic monitoring by proposing optimized initial dosing nomograms and assessing the feasibility of reduced blood sampling strategies using the most predictive models.
Methods: Models were identified from the literature and evaluated via an external neonatal population.
Deforestation exerts profound ramifications on soil quality and biodiversity, thereby exerting substantial economic repercussions. The depletion of organic matter and structural integrity of soil following tree removal for agricultural purposes underscores the severity of this issue. In elucidating the soil pollution stemming from deforestation, this research employs a sophisticated five-compartment SDIFR model integrating fractal dimension and fractional order dynamics.
View Article and Find Full Text PDFSolid-state bonding can form when metallic microparticles impact metallic substrates at supersonic velocities. While the conditions necessary for impact-induced metallic bonding are relatively well understood, the properties emerging at the bonded interfaces remain elusive. Here, we use in situ microparticle impact experiments followed by site-specific micromechanical measurements to study the interfacial strength across bonded interfaces.
View Article and Find Full Text PDFFlash floods represent a significant threat, triggering severe natural disasters and leading to extensive damage to properties and infrastructure, which in turn results in the loss of lives and significant economic damages. In this study, a comprehensive statistical approach was applied to future flood predictions in the coastal basin of North Al-Abatinah, Oman. In this context, the initial step involves analyzing eighteen General Circulation Models (GCMs) to identify the most suitable one.
View Article and Find Full Text PDFFlowers serve as hubs for biotic interactions with pollinators and microbes, which can significantly impact plant reproduction and health. Previous studies have shown that the flower microbiota undergoes dynamic assembly processes during anthesis. However, the influence of foraging pollinators on the assembly and dispersal of the flower microbiota and the transmission of plant pathogens remains poorly understood.
View Article and Find Full Text PDFObjective: The objective of this research is to examine the therapy and outlook of pediatric primary central nervous system Burkitt lymphomas.
Methods: This study involves a retrospective analysis of the clinical data of a child with primary central nervous system Burkitt lymphoma who underwent treatment in our department. In addition, pertinent literature was reviewed to provide a comprehensive understanding of the topic.
In this article, we explore exact solitary wave solutions to the van der Waals equation which is crucial for numerous applications involving a variety of physical occurrences. This system is used to define the behavior of real gases taking into consideration finite size of molecules and also has some applications in industry for granular materials. The model is studied under the effect of fractional derivatives by employing two different definitions: , and M-truncated.
View Article and Find Full Text PDFA four level chiral medium is considered to analyze and investigate theoretically the reflection/transmission coefficients of right circularly polarized (RCP) beam and left circularly polarized (LCP) beam as well as their corresponding GH-shifts under the effect of compton scattering. Density matrix formalism is used for calculation of electric and magnetic probe fields coherence. The polarization and magnetization are calculated from probes coherence terms in the chiral medium.
View Article and Find Full Text PDFThis work examines the (2+1)-dimensional Boiti-Leon-Pempinelli model, which finds its use in hydrodynamics. This model explains how water waves vary over time in hydrodynamics. We provide new explicit solutions to the generalized (2+1)-dimensional Boiti-Leon-Pempinelli equation by applying the Sardar sub-equation technique.
View Article and Find Full Text PDFIn this study, we introduce a novel iterative method combined with the Elzaki transformation to address a system of partial differential equations involving the Caputo derivative. The Elzaki transformation, known for its effectiveness in solving differential equations, is incorporated into the proposed iterative approach to enhance its efficiency. The system of partial differential equations under consideration is characterized by the presence of Caputo derivatives, which capture fractional order dynamics.
View Article and Find Full Text PDFThe COVID-19 pandemic came with many setbacks, be it to a country's economy or the global missions of organizations like WHO, UNICEF or GTFCC. One of the setbacks is the rise in cholera cases in developing countries due to the lack of cholera vaccination. This model suggested a solution by introducing another public intervention, such as adding Chlorine to water bodies and vaccination.
View Article and Find Full Text PDFDiabetic foot ulcers, as one of the chronic wounds, are a serious challenge in the global healthcare system which have shown notable growth in recent years. DFU is associated with impairment in various stages of wound healing, including angiogenesis. Aberrant expression of microRNAs (miRNAs) involved in the disruption of the balance between angiogenic and anti-angiogenic factors, plays a crucial role in angiogenesis dysfunction.
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