Publications by authors named "Hassanain Qambari"
Interpericyte Tunneling Nanotubes Are Nonuniformly Distributed in the Human Macula.
Invest Ophthalmol Vis Sci
November 2024
Purpose: Pericyte-to-pericyte communication via interpericyte tunneling nanotubes (IP-TNTs) is an important mechanism by which spatial and temporal precision in neurovascular coupling is achieved. This study quantifies the distribution and morphologic characteristics of IP-TNTs in the normal human macula.
Methods: Ultra high-resolution, three-dimensional microscopic imaging of 11 perfusion-labeled normal human donor eyes was performed.
Article Synopsis
- * Subclinical alterations in the retinal structure and function precede noticeable symptoms, impacting the neurovascular unit, including blood flow and cellular composition.
- * Identifying these early changes could guide effective treatment strategies and highlights the importance of advanced imaging techniques to detect these variations before they lead to clinical diseases.
Microvascular dysfunction is the underlying pathological process in many systemic diseases. However, investigation into its pathogenesis is impeded by the accessibility and complexity of the microvasculature within different organs, particularly for the central nervous system. The retina as an extension of the cerebrum provides a glimpse into the brain through which the microvasculature can be observed.
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