Synthesis of molecularly imprinted polymer as a nanosorbent for dispersive magnetic micro solid-phase extraction and determination of valsartan in biological samples by UV-Vis Spectrophotometry: Isotherm, kinetics, and thermodynamic studies.

A magnetic molecularly imprinted polymer (MIP) was synthesized by precipitation polymerization utilizing FeO@SiO-MPS as a magnetic core, itaconic acid as a functional monomer, azobisisobutyronitrile as an initiator, and ethylene glycol dimethacrylate as a cross linker. It was then applied as a nanosorbent for dispersive magnetic micro solid phase extraction (DM-µ-SPE) and determination of valsartan in biological fluids. The morphology and structure of magnetic MIP were characterized by Fourier-transform infrared spectroscopy, Field Emission Scanning electron microscopy, Vibrating sample magnetometer, Energy dispersive x-ray analysis, and Thermogravimetric analysis.

Co-delivery of doxorubicin and conferone by novel pH-responsive β-cyclodextrin grafted micelles triggers apoptosis of metastatic human breast cancer cells.

Adjuvant-aided combination chemotherapy is one of the most effective ways of cancer treatment by overcoming the multidrug resistance (MDR) and reducing the side-effects of anticancer drugs. In this study, Conferone (Conf) was used as an adjuvant in combination with Doxorubicin (Dox) for inducing apoptosis to MDA-MB-231 cells. Herein, the novel biodegradable amphiphilic β-cyclodextrin grafted poly maleate-co-PLGA was synthesized by thiol-ene addition and ring-opening process.

Novel pH-sensitive and biodegradable micelles for the combined delivery of doxorubicin and conferone to induce apoptosis in MDA-MB-231 breast cancer cell line.

pH-sensitive micelles are desirable for co-drug delivery in cancer chemotherapy. Herein, a novel, very pH-sensitive and biodegradable citric acid grafted poly maleate--poly lactic--glycolic acid was synthesized and assembled as micelles ultrasonication. The engineered homogeneous nanomicelles were used for the first time for doxorubicin and conferone combination chemotherapy in the MDA-MB-231 breast cancer cell line.

Novel ion imprinted polymer electrochemical sensor for the selective detection of lead(II).

The application of a novel Pb selective sensor based on the ionic imprinted polymer in determining trace levels of lead in natural water and in fruit juice was investigated using differential pulse voltammetry (DPV). The new and selective magnetic ion-imprinted polymer (FeO@SiO@IIP) was synthesized using 2-(2-aminophenyl)-1H-benzimidazole and 4-vinyl pyridine as a ligand and functional monomer, respectively. The new polymer was utilized for modifying a GCE to generate a new electrochemical sensor.

A novel magnetic ion imprinted polymer as a selective magnetic solid phase for separation of trace lead(II) ions from agricultural products, and optimization using a Box-Behnken design.

In this work, a magnetic ion-imprinted polymer (FeO@SiO@IIP) as a novel and selective nanosorbent for selective extraction of Pb(II) ions from various agricultural products is presented. The novel lead magnetic ion-imprinted polymer was synthesized by imidazole as a new ligand and grafted onto the surface of FeO@SiO NPs. A Box-Behnken (BBD) design was used for optimization of the extraction and elution steps.

Stirring-controlled solidified floating solid-liquid drop microextraction as a new solid phase-enhanced liquid-phase microextraction method by exploiting magnetic carbon nanotube-nickel hybrid.

A specific technique is introduced to overcome limitations of classical solidification of floating organic drop microextraction, such as tedious and time-consuming centrifuge step and using disperser solvent, by facile and efficient participation of solid and liquid phases. In this proposed method of stirring-controlled solidified floating solid-liquid drop microextraction (SC-SF-SLDME), magnetic carbon nanotube-nickel hybrid (MNi-CNT) as a solid part of the extractors are dispersed ultrasonically in sample solution, and the procedure followed by dispersion of liquid phase (1-undecanol) through high-rate stirring and easily recollection of MNi-CNT in organic solvent droplets through hydrophobic force. With the reduction in speed of stirring, one solid-liquid drop is formed on top of the solution.

Graphene-silica hybrid in efficient preconcentration of heavy metal ions via novel single-step method of moderate centrifugation-assisted dispersive micro solid phase extraction.

Novel nanoadsorbent of graphene-silica hybrid was synthesized via chemical vapor deposition (CVD) method. Graphene sheets were catalytically grown on a silica-based substrate and after being characterized by X-ray diffraction (XRD) and scanning electron microscopy (SEM), their high efficacy in adsorption of metal ions (lead, cadmium, and chromium) was examined. It was found that the presence of silica within the G-SiO2 structure imparts an amphiphilic property to the hybrid that enables it to interact with both free and bounded metal ions present in the biological samples.

Innovative separation and preconcentration technique of coagulating homogenous dispersive micro solid phase extraction exploiting graphene oxide nanosheets.

A uniquely novel, fast, and facile technique is introduced for the first time in which a scant amount of graphene oxide (GO), without modification, has been utilized in dispersive mode of solid phase extraction (SPE) for an efficient yet simple separation. The proposed method of coagulating homogenous dispersive micro solid phase extraction (CHD-µSPE) is based on coagulation of homogeneous GO solution with the aid of polyetheneimine (PEI). CHD-µSPE use full adsorption capacity of GO because in this method was used GO solution obtained from synthesis process without drying step and stacking nanosheets.

Column preconcentration and faas determination of heavy metal ions using Artemisia Siberi as an adsorbent.

A new column procedure for the determination of trace amounts of cadmium (II), lead (II), nickel (II), zinc (II), and copper (II), which combines flame atomic absorption spectrometry is described. These metals were sorbed on Artemisia siberi herb as an adsorbent at pH 4.0 and eluted with 3 mL of 1.