Publications by authors named "Hassan O Eliwan"
Selective modulation of monocyte and neutrophil responses with activated protein C in preterm infants.
J Matern Fetal Neonatal Med
December 2023
Background: Inflammation is associated with many disorders of preterm infants including periventricular leukomalacia, chronic lung disease, and necrotizing enterocolitis. Activated protein c (APC) has shown positive immunomodulatory effects.
Objectives: We aimed to study neutrophil and monocyte function in response to lipopolysaccharide (LPS) and APC stimulation in preterm infants <32 weeks gestation over the first week of life compared to neonatal and adult controls.
Article Synopsis
- - Sepsis is a critical issue in the Pediatric Intensive Care Unit (PICU), leading to high rates of illness and death, with affected patients often experiencing temporary immune system weakness.
- - Activated Protein C (APC) was initially thought to improve outcomes in sepsis, but recent trials show no benefits for either adults or children, leading researchers to investigate APC's effects on immune responses in PICU patients.
- - The study found that PICU patients had lower immune responses to bacteria and that APC treatment decreased harmful reactive oxygen production, suggesting APC might help improve immune function in severely ill children, particularly with newer formulations that have less risk of bleeding.