Core-shell structured magnetite carboxymethyl cellulose for cervical cancer treatment by maintaining methotrexate serum concentration.

In this work, we attempted to improve the properties of magnetite carboxymethyl cellulose nanoparticles (Mag CMC NPs) through Ugi multicomponent reaction (MCR) to obtain magnetite carboxymethyl cellulose@functionalized carboxamide nanoparticles (Mag CMC@FCA NPs) as a new nano bio-carrier. Typically, at first Mag CMC NPs prepared by the co-precipitation method. Then by performing the Ugi MCR on Mag CMC NPs, the Mag CMC@FCA NPs achieved better properties in swelling ratio, loading efficiency and loading capacity.

Hyaluronic acid functionalized citric acid dendrimer/UiO-66-COOH as a stable and biocompatible platform for daunorubicin delivery.

This work aimed to prepare a new system for daunorubicin (DNR) delivery to improve therapeutic efficiency and decrease unwanted side effects. Typically, at first, a carboxylic acid functional group containing metal-organic framework (UiO-66-COOH) was synthesized in a simple way. Then, a third generation of citric acid dendrimer (CAD G3) was grown on it (UiO-66-COOH-CAD G3).

Efficient adsorptive removal of used drugs during the COVID-19 pandemic from contaminated water by magnetic graphene oxide/MIL-88 metal-organic framework/alginate hydrogel beads.

Currently, the presence of drugs used in the COVID-19 pandemic in water bodies is worrisome due to their high toxicity, which necessitates their critical removal by developing highly efficient adsorbents. Hence, in this study, alginate hydrogel beads of magnetic graphene oxide@MIL-88 metal-organic framework (GO@FeO@MIL-88@Alg) were prepared for the first time and then utilized as a new absorption system for the removal of COVID-19 drugs such as doxycycline (DOX), hydroxychloroquine (HCQ), naproxen (NAP), and dipyrone (DIP) from aqueous solutions by batch adsorption manner. The effects of different experimental factors, such as adsorbent dosage, contact time, pH, drug concentration, temperature, ionic strength, presence of an external magnetic field (EMF), and magnet distance from the adsorption flask were optimized for the removal of COVID-19 drugs.

pH-sensitive biosystem based on laponite RD/chitosan/polyvinyl alcohol hydrogels for controlled delivery of curcumin to breast cancer cells.

In this study, a pH-responsive hydrogels based on laponite rapid dispersion (Lap®)/chitosan (CS)/polyvinyl alcohol (PVA) designed and was used for controlled delivery of the anticancer drug curcumin (CUR). First, it was accomplished by dissolving CUR in Lap® dispersion under the influence of the pH of the environment. Then, in the presence of Lap®CUR cross-linking was incorporated between CS and PVA polymers.

Cyclodextrin Host-Guest Recognition in Glucose-Monitoring Sensors.

Diabetes mellitus is a prevalent chronic health condition that has caused millions of deaths worldwide. Monitoring blood glucose levels is crucial in diabetes management, aiding in clinical decision making and reducing the incidence of hypoglycemic episodes, thereby decreasing morbidity and mortality rates. Despite advancements in glucose monitoring (GM), the development of noninvasive, rapid, accurate, sensitive, selective, and stable systems for continuous monitoring remains a challenge.

pH-sensitive biocompatible chitosan/sepiolite-based cross-linked citric acid magnetic nanocarrier for efficient sunitinib release.

In this study, the magnetite nanoparticles were immobilized on the sepiolite needles via co-precipitation of iron ions. Then, the resulted magnetic sepiolite (mSep) nanoparticles were coated with chitosan biopolymer (Chito) in the presence of citric acid (CA) to prepare mSep@Chito core-shell drug nanocarriers (NCs). TEM images showed magnetic FeO nanoparticles with small sizes (less than 25 nm) on the sepiolite needles.

Development of the new pH-driven carrier from alginate/carboxymethyl starch bio-coated co-drugs@COF-OH for controlled and concomitant colon cancer treatment.

To develop a new more efficient colon cancer treatment bio-vehicle, in frontier research, for the first time, an attempt has been made to design a unique colon-targeted bio-carrier containing polysaccharides along with nanoporous materials. So, at first, an imine-based covalent organic framework (COF-OH) with respectively an average pore diameter and surface area at 8.5058 nm and 208.

Fabrication of a new photoluminescent and pH-responsive nanocomposite based on a hyperbranched polymer prepared from amino acid for targeted drug delivery applications.

In this study, the FeO nanoparticles were encapsulated in the hyperbranched poly -lysine citramid (HBPLC). The FeO-HBPLC nanocomposite modified with -arginine and quantum dots (QDs) to obtain FeO-HBPLC-Arg/QDs as a new photoluminescent and magnetic nanocarrier for the pH-responsive release and targeted delivery of Doxorubicin (DOX). The prepared magnetic nanocarrier was fully characterized using different techniques.

Carboxymethyl cellulose@multi wall carbon nanotubes functionalized with Ugi reaction as a new curcumin carrier.

In recent years, the fabrication of new drug delivery systems (DDSs) based on functionalization by multi-component reactions (MCRs) has received special attention. In this regard, to obtain a new oral administration system for colon-specific cancer treatment, the CMC@MWCNTs@FCA carrier was designed and prepared from the functionalization of the CMC@MWCNTs as a biocompatible raw material with carboxamide group by the Ugi reaction. FT-IR analysis confirmed the successful synthesis of the product through the change in the functional groups of reagents.

Fabrication of biocompatible magnetic maltose/MIL-88 metal-organic frameworks decorated with folic acid-chitosan for targeted and pH-responsive controlled release of doxorubicin.

Recently, metal-organic frameworks (MOFs) have attracted tremendous attention as promising porous drug delivery systems for cancer treatment. In this work, for the first time, a novel magnetic maltose disaccharide molecule modified with MIL-88 metal-organic framework (FeO@C@MIL-88) was prepared, and then this targeted system was used for the delivery of the doxorubicin (DOX) drug. Eventually, FeO@C@MIL-88-DOX were successfully decorated with folic acid conjugated chitosan (FeO@C@MIL-88-DOX-FC) as a new targeted and controlled release drug system for treatment of MCF-7 breast cancer.

In-vitro evaluation of the 5-fluorouracil loaded GQDs@Bio-MOF capped with starch biopolymer for improved colon-specific delivery.

Herein, for the first time, the photoluminescent graphene quantum dots@Bio-metal organic framework (GQDs@Bio-MOF) nanohybrid was prepared. BET analysis obtained the average pore diameter of GQDs@Bio-MOF about 11.97 nm.

D-mannose functionalized MgAl-LDH/Fe-MOF nanocomposite as a new intelligent nanoplatform for MTX and DOX co-drug delivery.

Commonly the directly administered chemotherapy drugs lack targeting in tumor treatment. Thus, trying to improve cancer treatment efficiency led us to design a new intelligent system for cancer treatment. Considering these, in the current work, at first, the 2-aminoterephthalic acid (NH-BDC) intercalated layered double hydroxides (MgAl-(NH-BDC) LDH) were synthesized simply.

Design and fabrication of photoactive imidazole-based poly(ether-imide)s and a polyimide/HBP-modified SiO composite: toward high heat-resistance, antimicrobial activity and removal of heavy metal ions.

This article describes the synthesis and properties of novel imidazole-based aromatic polyimides (PIs) containing bulky groups from direct polycondensation of two diamines with 3,3',4,4'-benzophenone tetracarboxylic dianhydride (BTDA) and (hexafluoroisopropylidene)diphthalic anhydride (6FDA). The structure-property relationship of the prepared samples was fully determined FT-IR, H and C NMR and elemental analysis (CHN) techniques. The inherent viscosity values of the polyimides ranged from 0.

Magnetic alginate/glycodendrimer beads for efficient removal of tetracycline and amoxicillin from aqueous solutions.

The release of antibiotic drugs into aquatic environments is a serious environmental and health problem in recent years. Therefore, the development of potential adsorbents for the effective removal of tetracycline (TC) and amoxicillin (AMX) of aqueous media is of great importance. In this study, new alginate beads were successfully prepared by encapsulation of FeO@maltose-functionalized triazine dendrimer in alginate (Alg/FeO@C@TD) for the first time.

Folic acid-modified photoluminescent dialdehyde carboxymethyl cellulose crosslinked bionanogels for pH-controlled and tumor-targeted co-drug delivery.

This work aimed to fabricate a new photoluminescent bionanogel with both targeted anticancer drug delivery and bioimaging potentials. Briefly, at first photoluminescent carbon dots (CDs) were synthesized from the low-cost and more available black pepper with traditional medicinal properties. The as-synthesized dialdehyde carboxymethyl cellulose (DCMC) was used as a safe crosslinker for gelatin crosslinking in the presence of CDs (CDs/DCMC-Gel).

Carboxymethyl starch encapsulated 5-FU and DOX co-loaded layered double hydroxide for evaluation of its in vitro performance as a drug delivery agent.

Achieving a new oral drug delivery system with controlled drug release behavior is valuable in cancer therapy. Therefore, for the first time, doxorubicin (DOX) and 5-fluorouracil (5-Fu) were simultaneously co-loaded on the as-synthesized layered double hydroxides LDH(MgAl). The resulted system was encapsulated with carboxymethyl starch to improve its efficiency for colon cancer therapy.

Application or function of citric acid in drug delivery platforms.

Nontoxic materials with natural origin are promising materials in the designing and preparation of the new drug delivery systems (DDSs). Today's, citric acid (CA) has attracted a great deal of attention because of its special features; green nature, biocompatibility, low price, biodegradability, and commercially available property. So, CA has been employed in the preparation of the various platforms to induce a suitable property on their structure.

Facile synthesis of Zn-based metal-organic framework in the presence of carboxymethyl cellulose: A safe carrier for ibuprofen.

Fabrication of porous materials with a high surface area affords a great interest to achieve a system with a prolonged drug release manner. In this context, the subject of this work is to describe a novel green one-pot synthesis route for the growth of metal-organic framework (MOF) from zinc metal (Zn) and 1, 4-benzene dicarboxylic acid (BDC) in the vicinity of the carboxymethyl cellulose (CMC), which homogeneously confined in the biopolymeric chains. The synthesized Zn (BDC)@CMC was characterized and confirmed using different analyses.

Chitosan coated FeO@Cd-MOF microspheres as an effective adsorbent for the removal of the amoxicillin from aqueous solution.

In this work, for the first time, a new magnetic cadmium-based MOFs (FeO@Cd-MOF) was successfully synthesized in a green way and then modified with chitosan (CS) in the microsphere form (FeO@Cd-MOF@CS). The obtained materials were fully characterized by several techniques. In the following, the efficiency of FeO@Cd-MOF@CS was explored for the removal of amoxicillin (AMX).

Developments on carboxymethyl starch-based smart systems as promising drug carriers: A review.

Conventional drug administrations are associated with low bioavailability, high cost, more side effects, uncontrolled release profile, and patient noncompliance. Therefore, the development of an alternative to traditional drug delivery systems (DDSs) is of crucial significance. Up to now, various materials have been investigated for these purposes, among them, carboxymethyl starch (CMS) owing to its specific advantages has been studied for extensively drug delivery, particularly for oral administration.

Simple method for fabrication of metal-organic framework within a carboxymethylcellulose/graphene quantum dots matrix as a carrier for anticancer drug.

Biocompatible drug delivery vehicles with sustained drug release property are valuable in cancer therapy and can reduce some of the side effects. Hence, to achieve the biocompatible system with sustained drug release behavior a new drug carrier was fabricated via in situ synthesis of MIL-53 (MIL = Materials of Institute Lavoisier) within the carboxymethylcellulose/graphene quantum dots matrix (CMC/GQDs) as a biological macromolecule based platform (MIL-53@CMC/GQDs). Fourier transform infrared (FT-IR), and X-ray diffraction (XRD) analysis revealed successful synthesis of MIL-53@CMC/GQDs.

Synthesis of photoluminescent glycodendrimer with terminal β-cyclodextrin molecules as a biocompatible pH-sensitive carrier for doxorubicin delivery.

In the present research, we prepared new glycodendrimer containing β-cyclodextrin (β-CD) in three steps. At first, graphene quantum dots (GQDs) synthesized through pyrolysis of the citric acid (CA). Then the polyamidoamine (PAMAM) dendrimer was grown from the surface of the modified GQDs (GQDs-PAMAM).

Facile preparation of pH-sensitive chitosan microspheres for delivery of curcumin; characterization, drug release kinetics and evaluation of anticancer activity.

Curcumin (CUR) is a lowly water-soluble natural polyphenol with chemopreventive and chemotherapeutic activities. Hence, to achieve the system with good CUR loading ability, porous MIL-88 (Fe) was prepared in the presence of the presynthesized graphene quantum dots (GQDs) (GQDs@MIL-88 (Fe)). In the following, CUR loaded in the fabricated GQDs@MIL-88 (Fe) nanohybrid.

Simple preparation of maltose-functionalized dendrimer/graphene quantum dots as a pH-sensitive biocompatible carrier for targeted delivery of doxorubicin.

In the present study, a novel magnetic carbon modified with 3-aminopropyltrimethoxysilane (APTMS) using maltose disaccharide molecule as a green capping agent, and a third-generation triazine dendrimer (FeO@C@TD-G3) was then covalently attached to their surface. Eventually, FeO@C@TD-G3 was reacted with graphene quantum dots (GQDs) for the preparation of final FeO@C@TDGQDs microspheres. The obtained compound was successfully applied as a novel magnetic carrier for the Doxorubicin (DOX) drug delivery.