Novel Silk Fibroin Based Bilayer Scaffolds for Bioabsorbable Internal Biliary Stenting.

Biliary duct reconstruction is one of the most challenging parts of liver transplantation and accounts for 40%-60% of complications. While current stent-based devices on the market show promising results in reducing complications, they are manufactured from permanent synthetic materials and require a second reintervention for their removal. This exposes the patients to other potential complications and increases healthcare costs.

extract mediated, sustainable silver nanoparticle synergetic with heterocyclic antibiotic clarithromycin and their antimicrobial activities.

Microorganisms are becoming resistant to drugs and antimicrobials, making it a significantly critical global issue. Nosocomial infections are resulting in alarmingly increasing rates of morbidity and mortality. Plant derived compounds hold numerous antimicrobial properties, making them a very capable source to counteract resistant microbial strains.

Synergistic effects of allantoin and Achyranthes japonica-biochar profoundly alleviate lead toxicity during barley growth.

Lead (Pb), a toxic metal, causes severe health hazards to both humans and plants due to environmental pollution. Biochar addition has been efficiently utilized to enhance growth of plants as well as yield in the presence of Pb-induced stress. The present research introduces a novel use of biochar obtained from the weed Achyranthes japonica to enhance the growth of plants in Pb-contaminated soil.

Whole-genome evaluation and prophages characterization associated with genome of carbapenem-resistant Acinetobacter baumannii UOL-KIMZ-24-2.

Carbapenem-resistant Acinetobacter baumannii (CRAB) is an emerging threat to healthcare settings in many countries, principally in South Asia. The current study was aimed to identify, evaluate whole-genome and characterize the prophages in genome of CRAB strain, recovered from patients of Lahore General Hospital, Lahore. More than 200 samples were collected and identified by morphological and biochemical tests.

Cross-Point Ferroelectric HfZrO Capacitors for Remanent Polarization-Driven In-Memory Computing.

Ferroelectric HfZrO (HZO) capacitors have been extensively explored for in-memory computing (IMC) applications due to their nonvolatility and back-end-of-line (BEOL) compatible process. Several IMC approaches using resistance and capacitance states in ferroelectric HZO have been proposed for vector-matrix multiplication (VMM), but previous approaches suffer from limited accuracy and reliability. In this work, we propose a promising approach centered on the remanent polarization (P) switching of binary ferroelectric HZO capacitor synapses.

Physalis peruviana calyces extract ameliorate oxidative stress, inflammation, and immune loss in rats-exposed to hexaflumuron.

Background: Hexaflumuron (HFM), a common pesticide, can disrupt the immune system and cause oxidative stress. This study investigated the potential of Physalis peruviana L. calyces extract (PP) to counteract these effects in rats.

Self-medication pattern among medical students in Middle Delta, Egypt.

Background: Self- medication leading to wastage of limited resources in developing countries, prolonged suffering, increase resistance to drugs and may result in significant medical complications such as adverse drug responses and dependence. Self-medication is extensively used by health professionals. Undergraduate medical students as being the future physicians representing a main pillar in health care system thus have special significance.

Oral supplementation of curcumin-encapsulated chitosan nanoconjugates as an innovative strategy for mitigating nickel-mediated hepatorenal toxicity in rats.

Nickel pollution adversely affects human health and causes various disorders, mainly hepatic and renal dysfunction. The present work focused on a comparative evaluation of the pure form of curcumin (CU) with curcumin-encapsulated chitosan nanoconjugates (CS/CU NCs), on mitigation of the delirious effects of Ni on hepatorenal tissue. Forty-two male rats were allocated into 6 groups (n = 7 for each) as follows: (1) control, (2) CU, (3) CS/CU NCs, (4) Ni, (5) Ni + CU, (6) Ni + CS/CU NCs.

Incidence of Communicating Hydrocephalus Following Intraventricular Hemorrhage Among Adult Patients Treated at a Hospital in Jeddah, Saudi Arabia: A Retrospective Study.

Introduction Intraventricular hemorrhage is a severe condition caused by bleeding within the brain ventricles. It is often due to trauma, tumors, vascular malformation, aneurysm, oxygen deprivation, or idiopathic. A common complication associated with intraventricular hemorrhage is hydrocephalus, which is the accumulation of cerebrospinal fluid in the ventricles.

Synthesis and antimicrobial evaluation of a new hybrid bis-cyanoacrylamide-based-piperazine containing sulphamethoxazole moiety against rheumatoid arthritis-associated pathogens.

Piperazine-based compounds have garnered significant attention due to their notable biological and pharmacological activities, making them essential in fine chemical and pharmaceutical applications. In this study, we managed to synthesize a novel hybrid bis-cyanoacrylamide bearing the piperazine core via phenoxymethyl linker and incorporating sulphamethoxazole moiety. The novel compound was fully characterized using different spectral data including 1H-NMR, C-NMR, and FTIR spectroscopy.

Role of toxic and essential elements in sleep duration of patients with cardiovascular diseases.

Sleep disorders are a common aspect of cardiovascular diseases (CVDs) that can negatively impact a patient's quality of life, trigger coronary events, accelerate disease progression, and influence patient survival. This study aimed to investigate the relationship between essential and toxic elements with sleep duration among CVD patients. The study utilized cross-sectional data from 150 patients with CVDs (n = 150) from the Ravansar Non-Communicable Disease (RaNCD) Cohort Study.

Evaluation of multidrug resistance in the Gram-negative microbiome of cancer patients and the adverse effects of their metabolites on albino rats and epithelial or fibroblasts cell lines.

Background: Cancer is a significant global health issue due to its high incidence and mortality rates. In recent years, the relationship between the human microbiota and cancer has garnered attention across various medical fields. This includes research into the microbial communities that influence cancer development, tumor-associated microorganisms, and the interactions between the microbiome and tumor, collectively referred to as the oncobiome.

Optimal sandwich panel's core design for an enhanced impact resistance.

Despite the extensive literature revealing various core structures that can enhance the impact resistance of composite panels, a comparative study illustrating the difference in performance of the various cores under same loading conditions is missing. The aim of this study is to determine the optimal core structure and design in terms of energy absorption under low-velocity impact using both numerical simulations and experimental testing for validation. Response surface analysis was used to design the experiments and analyse the panel's behaviour.

Psychological impact and coping mechanisms among sudanese medical students: a study on anxiety, depression, behavioral, and cognitive changes post COVID-19 lockdown and ongoing conflict.

Introduction: Mental health is crucial for overcoming obstacles, completing tasks, and contributing to society. Mental, social, and cognitive healths are included. In demanding fields like medicine, academic pressure can cause exhaustion, poor performance, and behavioral changes.

Analysis of the genome data of UOL-KIMZ-24, exhibiting multiple drug resistance through efflux pumps.

is a well-known opportunistic pathogen, responsible for various nosocomial infections. UOL-KIMZ-24 was previously isolated from a clinical specimen, collected from Lahore General Hospital, Lahore (LGH), Pakistan, dated 3rd March, 2022. During the initial screening for antimicrobial susceptibility, the UOL-KIMZ-24 was found a multiple drug resistant (MDR) strain.

Dimensional Accuracy of Intraoral Scanners in Recording Digital Impressions of Post and Core Preparations: A Systematic Review.

Background: This study aims to perform a review by selecting, analyzing, and evaluating articles that discuss the accuracy of intraoral scanners (IOSs) in recording post space compared to conventional impression-making techniques.

Methods: The review question framed using the PITR framework (participant, index test, targeted condition, and reference standard) is as follows: What is the dimensional accuracy (T) of impressions made using intraoral scanners (I) for post space (P) compared to impressions made using conventional techniques and digitalized using extraoral scanners (R)? Four electronic databases were searched using pre-set keywords. The guidelines and strategies recommended by PRISMA formed the basis for planning, executing, and documenting this systematic review.

Lethal Phenotype and Expansion of the Clinical Spectrum of Biallelic Loss of Function Variant in SENP7 Gene Unveiled by Whole Exome Sequencing.

SUMOylation involves covalent attachment of small ubiquitin-like modifier (SUMO) proteins to specific lysine residues on target proteins and regulates various aspects of their function. Sentrin-specific proteases (SENPs) are key players in both the conjugation reaction of SUMO proteins to their targets and the subsequent deconjugation of SUMO-conjugated substrates. Here, we provide the first comprehensive prenatal description of a lethal syndrome linked to a novel homozygous stop-gain variant in SENP7 c.

Screening of bioactive components in dried oleo-gum resin and assessment of its protective function against cadmium-induced oxidative damage, genotoxicity, and cytotoxicity in rats.

Cadmium (Cd) is among the most ecologically harmful heavy metals. The purpose of this work was to identify the biologically active components in dried oleo-resin-gum of extract (FAE) and assess their preventive efficacy against oxidative damage caused by Cd in rats. The biologically active components were identified using HPLC and GC-MS.

Proposed Utilization of PlGF-Based Diagnostic Testing for Suspected Preeclampsia in Québec: Insights From an Expert Panel Discussion.

Prompt diagnosis of preeclampsia is key to ensure appropriate management and reduce associated adverse outcomes. Placental growth factor (PlGF)-based biomarkers have been shown to be safe and effective diagnostic tools for preterm preeclampsia, and their use is recommended by most recent Canadian guidelines. The present report summarizes an expert panel discussion that led to the development of a proposed utilization algorithm for PlGF-based diagnostic testing for suspected preeclampsia in Québec.

Draft genome sequence of FH1.

Phytopathogens with multi-drug resistance are emerging frequently, resulting in various disease outbreaks. Hence, exploring new antimicrobials is urgent. Here, we present the draft genome sequence of FH1 strain, with the potential to produce various antimicrobial compounds.

Rational design, synthesis, biological evaluation, molecular docking, and molecular dynamics of substituted uracil derivatives as potent anti-cancer agents.

An efficient synthesis of a series of uracil analogous was performed to obtain new potential anticancer agents. The cytotoxic effect of the synthesized derivatives was assessed in vitro against three cancer cell lines, namely hepatic cancer (HepG-2), colon cancer (HCT-116), and breast cancer (MCF-7). Among the tested compounds, 5, 11 and 15 stood as potent uracil derivatives with pan cytotoxicity against the 3 cell lines out-performing the reference compound 5-FU.

Propolis extract nanoparticles alleviate diabetes-induced reproductive dysfunction in male rats: antidiabetic, antioxidant, and steroidogenesis modulatory role.

Diabetes can affect male fertility via oxidative stress and endocrine system disruption. Nanomedicine based on natural products is employed to address diabetes complications. The current study aims to investigate the potential beneficial effect of propolis extract nanoparticles against diabetes-induced testicular damage in male rats.