ADMISSION FRAILTY SCORE AS A GOOD CLINICAL SUBSTITUTE OF SOFA SCORE TO PROGNOSTICATE POST-PERCUTANEOUS CORONARY INTERVENTION PATIENTS ON ADVANCED LIFE-SUPPORT.

Background: This study aimed to assess and compare the prognostic value of frailty score (FS), Sequential Organ Failure Assessment (SOFA) score, and additive of FS and SOFA score, at the time of admission to the coronary care unit (CCU), for the prediction of short-term poor prognosis in post-myocardial infarction (MI) patients, requiring advanced life-support.

Methods: A cohort of post-MI patients admitted to CCU. The FS and SOFA score were obtained at the time of CCU admission.

Amelioration of fat clay treated with CNS and cohesionless soils.

The present study evaluates the amelioration of fat clay by blending it with cohesive non-swelling soil (CNS) and cohesionless silty sandy soil (Kassu). The fat clay sample with a liquid limit (LL) of 50 and a plasticity index (PI) of 26 was collected from Narowal, while CNS and Kassu samples were procured from Lahore's outskirts. Geotechnical tests on the virgin soil indicated its unsuitability for construction.

Galectin-8N-Selective 4-Halophenylphthalazinone-Galactals Double π-Stack in a Unique Pocket.

Galectin-8 contains two different carbohydrate recognition domains (CRDs). Selective inhibitors for at least one CRD are desirable for galectin-8 biology studies and potentially for pharmacological purposes. Structure-guided design led to the discovery of potent and selective glycomimetic-heterocycle hybrid ligands, with a 4-(-bromophenyl)phthalazinone derivative displaying a 34 μM for galectin-8N (N-terminal CRD), no binding to galectin-8C (C-terminal CRD), -1, -3, -4N, -7, -9C, or -9N, and >40-fold selectivity over galectin-4C.

Environmental impacts and performance assessment of recycled fine aggregate concrete.

Natural disasters and human demolition create vast amounts of construction and demolition waste (CDW), with a substantial portion being concrete waste. Managing this concrete waste is a daunting challenge for developing countries with limited resources, aiming to mitigate its harmful environmental effects. Therefore, the proposed approach involves using recycled fine aggregates (RFA) instead of fresh fine aggregates (FFA) in concrete, which aligns closely with achieving sustainable environmental objectives.

Characteristics and health implications of fine particulate matter near urban road site in Islamabad, Pakistan.

The escalating issue of air pollution has become a significant concern in urban regions, including Islamabad, Pakistan, due to the rise in air pollutant emissions driven by economic and industrial expansion. To gain a deeper understanding of air pollution, a study was conducted during winter 2022-2023, assessing physical, chemical, and biological factors in Islamabad. The findings revealed that the average concentration of fine particulate matter (PM2.

Steroids and myocardial infarction: Investigating safety and short-term mortality in critical post-myocardial infarction patients.

Background: Conventionally, in the pre-percutaneous intervention era, free wall rupture is reported to be a major concern for using steroids in myocardial infarction (MI) patients. Therefore, the aim of this study was to evaluate the safety of the use of steroids in critically ill post-MI patients in terms of hospital course and short-term (up to 180-day) mortality.

Methods: We included patients admitted to CCU diagnosed with MI, undergone revascularization, critically ill, and requiring mechanical ventilator (MV) support.

Societal knowledge, attitude, and practices towards dengue and associated factors in epidemic-hit areas: Geoinformation assisted empirical evidence.

Dengue is one of Pakistan's major health concerns. In this study, we aimed to advance our understanding of the levels of knowledge, attitudes, and practices (KAPs) in Pakistan's Dengue Fever (DF) hotspots. Initially, at-risk communities were systematically identified via a well-known spatial modeling technique, named, Kernel Density Estimation, which was later targeted for a household-based cross-sectional survey of KAPs.

Intramedullary Thoracic Spinal Cord Abscess Mimicking an Intramedullary Tumor: A Case Report.

An intramedullary abscess is an extremely rare form of infection of the spinal cord, with only about 100 cases reported in the literature. It typically presents with back pain, neurological deficits, and, occasionally, fever. The purpose of this article is to report a case of an intramedullary thoracic spinal cord abscess that was initially misdiagnosed as an intramedullary tumor.

Comprehensive insights into advances in ambient bioaerosols sampling, analysis and factors influencing bioaerosols composition.

While the study of bioaerosols has a long history, it has garnered heightened interest in the past few years, focusing on both culture-dependent and independent sampling and analysis approaches. Observations have been made regarding the seasonal fluctuations in microbial communities and their connection to particular ambient atmospheric factors. The study of airborne microbial communities is important in public health and atmospheric processes.

Climatic and topographic controls on glacial changes (1973-2020) in Shigar Basin, Central Karakoram, Northern Pakistan.

The Hindukush, Karakorum, and Himalaya (HKH) mountains are often referred to as the "Third Pole" because of high snow, being a major freshwater resource and early indicator of climate change. Therefore, research on the dynamics of glacier changes and their relationship with climate and topographic variability is essential for sustainable water resource management and adaptation strategies in Pakistan. In this contribution, we delineated 187 glaciers and examined these glacier changes in the Shigar Basin from 1973 to 2020 using Corona, Landsat Operational Land Imager/Enhanced Thematic Mapper Plus/Thematic Mapper/Multispectral Scanner System (OLI/ETM/TM/MSS), Alaska Satellite Facility (ASF), and Shuttle Radar Topography Mission Digital Elevation Model (SRTM DEM) imageries.

Dietary Supplementation of Microbial Dextran and Inulin Exerts Hypocholesterolemic Effects and Modulates Gut Microbiota in BALB/c Mice Models.

Microbial exopolysaccharides (EPSs), having great structural diversity, have gained tremendous interest for their prebiotic effects. In the present study, mice models were used to investigate if microbial dextran and inulin-type EPSs could also play role in the modulation of microbiomics and metabolomics by improving certain biochemical parameters, such as blood cholesterol and glucose levels and weight gain. Feeding the mice for 21 days on EPS-supplemented feed resulted in only 7.

N-BAR and F-BAR proteins-endophilin-A3 and PSTPIP1-control clathrin-independent endocytosis of L1CAM.

Recent advances in the field demonstrate the high diversity and complexity of endocytic pathways. In the current study, we focus on the endocytosis of L1CAM. This glycoprotein plays a major role in the development of the nervous system, and is involved in cancer development and is associated with metastases and poor prognosis.

Galectin-8 Downmodulates TLR4 Activation and Impairs Bacterial Clearance in a Mouse Model of Pseudomonas aeruginosa Keratitis.

Pseudomonas aeruginosa provokes a painful, sight-threatening corneal infection. It progresses rapidly and is difficult to treat. In this study, using a mouse model of P.

Role Of Lung Ultrasound During Weaning In Patient With Mitral Regurgitation Post Angioplasty.

Background: We hypothesize that a change in lung ultrasound score (LUS) can assist in the early diagnosis of weaning-induced respiratory failure (RF). The objective of this study was to determine the utility of LUS in weaning patients with mitral regurgitation (MR) from mechanical ventilation (MV).

Methods: This prospective observational study included patients with acute coronary syndrome (ACS) who required invasive MV after angiography/angioplasty.

Modeling the fecal contamination (fecal coliform bacteria) in transboundary waters using the scenario matrix approach: a case study of Sutlej River, Pakistan.

Surface water quality is among the significant challenges in the Sutlej River basin, passing through Pakistan's most densely populated province. Currently, the overall surface water quality is grossly polluted, mainly due to the direct discharge of wastewater from the urban areas to the Sutlej River directly or through stream networks. Escherichia coli concentrations vary under extreme weather events like floods and droughts and socioeconomic circumstances like urbanization, population growth, and treatment options.

Understanding the role of atmospheric circulations and dispersion of air pollution associated with extreme smog events over South Asian megacity.

The winter fog/haze events in northeastern Pakistan and surrounding regions of India are often mixed with pollutants to form smog, and consequently damage human health and hampers daily life in the form of fatalities through road accidents, road blockages, and flight delays. The persistent anti-cyclonic conditions can further trigger the temperature inversion and prolong the smog event from days to weeks. The present study provides characteristics and lasting mechanisms of two persistent winter fog events (2016-2017) in Lahore, Pakistan, by using the fifth generation of European Center for Medium-Range Weather Forecast (ECMWF) ERA5 reanalysis data and National Oceanic and Atmospheric Administration (NOAA) Hybrid Single-Particle Lagrangian Integrated Trajectory (HYSPLIT) model simulated with Global Data Assimilation System (GDAS) meteorological data.

Structure-Guided Design of d-Galactal Derivatives with High Affinity and Selectivity for the Galectin-8 N-Terminal Domain.

Galectin-8 is a carbohydrate-binding protein that plays a crucial role in tumor progression and metastasis, antibacterial autophagy, modulation of the immune system, and bone remodeling. The design, synthesis, and protein affinity evaluation of a set of C-3 substituted benzimidazole and quinoline d-galactal derivatives identified a d-galactal-benzimidazole hybrid as a selective ligand for the galectin-8 N-terminal domain (galectin-8N), with a of 48 μM and 15-fold selectivity over galectin-3 and even better selectivity over the other mammalian galectins. X-ray structural analysis of galectin-8N in complex with one benzimidazole- and one quinoline-galactal derivative at 1.

Benzimidazole-galactosides bind selectively to the Galectin-8 N-Terminal domain: Structure-based design and optimisation.

We have obtained the X-ray crystal structure of the galectin-8 N-terminal domain (galectin-8N) with a previously reported quinoline-galactoside ligand at a resolution of 1.6 Å. Based on this X-ray structure, a collection of galactosides derivatised at O3 with triazole, benzimidazole, benzothiazole, and benzoxazole moieties were designed and synthesised.

Frequency and Characteristics of Metabolic Syndrome in Patients With Ischemic Stroke Admitted to a Tertiary Care Hospital in Karachi.

Introduction Metabolic syndrome (MetS) is defined as a syndrome of truncal obesity, insulin resistance, hypertension, hypertriglyceridemia, and dyslipidemia. It is well known that MetS increases the risk of cardiovascular disease and adverse events. Each of its components is associated with an increased risk of cardiovascular disease, but data on the association with ischemic stroke are scarce.

Satisfaction Levels of Medical Attendants at a Pakistani Emergency Department.

Introduction Healthcare services all over Pakistan are facing an ever-growing patient flow. Rapid urbanization and a population boom are mainly responsible for this phenomenon. This is most evident in the emergency department.

Evaluation of the environmental epidemiologic data and methodology for the air quality standard in Beijing.

To evaluate the relationship between exposure to air pollutants and respiratory emergency room visits, a generalized additive model (GAM) was used to analyze the exposure-effect relationship between air pollutants and respiratory emergency room visits. The results showed that NO, SO, and PM have positive relationships with respiratory disease. Concentration increases of 10 μg/m in NO, SO, and PM corresponded to 3.

Pharmacy Apps: a new frontier on the digital landscape?

Background: Over the course of recent years smartphone and tablet technology has evolved rapidly. Similarly, the sphere of healthcare is constantly developing and striving to embrace the newest forms of technology in order to optimise function. Many opportunities for mobile applications (i.