Publications by authors named "Hassan Mahmoud"

Background And Aims: Even though patient tolerance is critical to the success of noninvasive ventilation (NIV), research on using sedation to improve tolerance to NIV after traumatic chest injuries is limited. We hypothesized that dexmedetomidine would be superior to ketamine in terms of patient tolerance and lengthening the NIV sessions after blunt chest trauma.

Material And Methods: This randomized, double-blinded, placebo-controlled trial included 45 patients of both genders aged 18-60 who needed NIV after blunt chest trauma.

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Background: There is no significant evidence verifying the efficacy of liberal versus conservative oxygen therapy on hemodynamics in patients with sepsis. We investigated how liberal and conservative oxygen therapy influenced stroke volume, cardiac output, and vasopressor needs in patients with sepsis undergoing mechanical ventilation.

Methods: This randomized clinical trial included 106 patients with an admission diagnosis of infection, a Sequential Organ Failure Assessment (SOFA) score of two points or higher and required invasive mechanical ventilation for at least 72 h.

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Introduction: About 80% of patients receiving chemotherapeutics suffer from side effects related to the gastrointestinal tract. Irinotecan (CPT-11) is a chemotherapeutic agent usually used in treating solid tumors. Quercetin (QRT), a bioflavonoid, is an antioxidant and scavenger reactive oxygen species scavenger.

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Epidermal growth factor (EGF) plays a crucial role in maintaining male reproductive capacity in mammals, however, its protective effects on cryopreserved dromedary camel epididymal spermatozoa have not been thoroughly investigated. This study aims to investigate the potential protective role of EGF on cryopreserved camel epididymal spermatozoa, supported by evidence from a molecular docking study. We assessed sperm motility, kinematics parameters, oxidative stress, ultrastructural changes, apoptosis, and molecular docking markers in camel epididymal spermatozoa following cryopreservation.

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Interfaces play a critical role in modern structures, where integrating multiple materials and components is essential to achieve specific functions. Enhancing the mechanical performance of these interfaces, particularly their resistance to delamination, is essential to enable extremely lightweight designs and improve energy efficiency. Improving toughness (or increasing energy dissipation during delamination) has traditionally involved modifying materials to navigate the well-known strength-toughness trade-off.

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Background/aim: A key aspect of hand function is dexterity, which is described as fine voluntary movements used to manipulate small objects during a specific task. The contralateral hand in children with unilateral cerebral palsy (U-CP); is commonly referred to as a "good" and "unimpaired" hand, while others have noted that it has subtle limitations. Therefore, this study aimed to assess and compare between the strength and dexterity of less-affected hand of children with U-CP and the dominant hand of normal peers.

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Contextual interference (CI) enhances learning by practicing motor tasks in a random order rather than a blocked order. One hypothesis suggests that the benefits arise from enhanced early perceptual/attentional processes, while another posits that better learning is due to highly activated mnemonic processes. We used high-density electroencephalography in a multi-scale analysis approach, including topographic analyses, source estimations, and functional connectivity, to examine the intertwined dynamics of attentional and mnemonic processes within short time windows.

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  • Pregnant women are at higher risk for negative effects from COVID-19, especially depending on the trimester in which they contract the virus.
  • A significant portion (71.4%) of the study's participants required hospitalization due to COVID-19, with severity linked to symptoms like shortness of breath.
  • Adverse outcomes for mothers and babies were worst in the third trimester, with increased hospitalization, maternal deaths, and post-COVID symptoms like loss of smell and myalgia being more common in this group.
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  • This study addresses the taxonomic complexity of the Tourn. ex L. genus in Egypt, aiming to identify species and analyze their fatty acid profiles as a means of classification when reproductive cones are absent.
  • Researchers collected 120 specimens from 20 different habitats, examining 30 vegetative traits and 72 reproductive traits; they identified five species in the Egyptian flora, with South Sinai being the main diversity hotspot.
  • The study found significant variations in fatty acid content among species, demonstrating that both morphological traits and lipid profiles can serve as effective tools for species identification in the absence of reproductive cones.
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  • The study aimed to evaluate the significance of visualizing the pterygomandibular raphae (PMR) while attaching the palatopharyngeous muscle (PPM) during surgeries for obstructive sleep apnea (OSA).
  • Conducted as a randomized controlled trial, the research compared two groups of OSA patients: one where the PMR was visualized during surgical procedures and another where it was not, finding no significant difference in surgical outcomes between the two groups.
  • While fixation of PPM to the PMR under direct vision didn't significantly improve results, it may enhance surgical efficiency and lower the risk of complications, acknowledging that some patients may not have a visible PMR
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Nanomaterials offer several promising prospects in the field of farm animal reproduction, encompassing a broad range of applications such as transgenesis and the precise delivery of substances to sperm cells, antimicrobial, antioxidants properties as well as their potent role in improving cryopreservation methods. The aim of the present study is to explore the effect of supplementing the semen extender with 10 µg/mL nano gold (Au-NPs10), 10 µg/mL nano silver (Ag-NPs10), 1 µg/mL nano selenium (Se-NPs1), and 100 µg/mL nano zinc oxide (ZnO-NPs100) on sperm characteristics and kinematics parameters, acrosome integrity, oxidative biomarkers, morphological and apoptosis-like changes of frozen-thawed buffalo bull sperm, and, ultimately, their fertilizing capacity. The results revealed that all aforementioned nano materials significantly improved viability, progressive motility, membrane integrity, acrosome integrity, and kinematic parameters as well as apoptosis-like changes of post-thawed buffalo bull sperm compared to the control (p < 0.

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  • Cadmium (Cd) is a harmful metal that can negatively impact the health of humans and animals, prompting this study to investigate its effects on rats' submandibular glands.
  • The study involved 32 rats divided into four groups, assessing the impact of Spirulina platensis (SP), a nutrient-rich algae, on Cd-induced damage over a 24-day period.
  • Results showed that while Cd caused oxidative stress and inflammation in the submandibular glands, the addition of SP significantly mitigated these damages, suggesting its potential as a protective supplement against Cd toxicity.
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  • Tick-borne diseases are on the rise globally, but there's limited research on their impact on dogs in southern Egypt.
  • A study detected Anaplasma marginale and Babesia canis vogeli in dog blood, finding a 4% infection rate, with a higher occurrence in male dogs (75%) compared to females (25%).
  • This research is the first to report the presence of A. marginale in dogs in southern Egypt, using genetic analysis to compare it with isolates from other animals in the region.
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  • - The study investigates how resting-state brain networks are linked to creativity using high-density electroencephalography (HD-EEG) in 90 healthy participants who completed a creative behavior inventory.
  • - Researchers employed machine learning techniques to analyze brain connectivity patterns, finding significant differences in functional connectivity in the gamma frequency band related to high and low creativity levels.
  • - Their predictive model demonstrated good accuracy in forecasting individual creativity scores and was validated with a separate dataset, suggesting potential biomarkers for creativity based on brain networks.
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Background: Patient safety learning systems play a critical role in supporting safety culture in healthcare organisations. A lack of explicit standards leads to inconsistent implementation across organisations, causing uncertainty about their roles and impact. Organisations can address inconsistent implementation by using a self-assessment tool based on agreed-on best practices.

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Background: Tick-borne diseases cause economically significant losses to animal production globally, and anaplasmosis and theileriosis are associated with the greatest losses. However, the spread of the relevant pathogens in flocks of domesticated animals in southern Egypt is little understood. Accordingly, in this study, we aimed to determine the prevalences of Anaplasma ovis, Theileria ovis, and Theileria lestoquardi in southern Egyptian sheep and goats through blood tests, and to make a molecular characterization of the A.

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Sperm cryopreservation can lead to subfertility due to potential damage to sperm DNA, membranes, and overall motility caused by the freeze-thaw process. Interleukin-6 (IL-6) is a versatile cytokine with various roles in reproductive processes. However, the impacts of IL-6 supplementation on cryopreserved ram sperm have not been thoroughly investigated.

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In Egypt, tick-borne diseases pose a significant threat to human and animal health, and the threat to dromedaries (Camelus dromedarius), the country's dominant camelid species, is of particular concern. These animals are frequently infested with ticks, and may thus develop tick-borne diseases or become reservoirs of tick-borne pathogens. However, there is a paucity of data on tick infestation in Egyptian camels, especially in the south of the country.

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  • The study focused on the genetic analysis of the bovine leukocyte antigen (BoLA), essential for immune response, in Egyptian cattle populations, which hadn't been previously researched.
  • Researchers identified 54 known and 8 new BoLA-DRB3 alleles using the PCR-SBT method, revealing significant genetic diversity among local cattle breeds.
  • The allele frequencies indicated that native and mixed Egyptian cattle share closer genetic ties with African breeds, while Holstein cattle were more distinct and aligned with Holstein populations from other countries.
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The fifth Industrial revolution (I5.0) prioritizes resilience and sustainability, integrating cognitive cyber-physical systems and advanced technologies to enhance machining processes. Numerous research studies have been conducted to optimize machining operations by identifying and reducing sources of uncertainty and estimating the optimal cutting parameters.

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