Apatite induced renal epithelial injury: insight into the pathogenesis of kidney stones.

Purpose: Kidney stone formation is associated with the deposition of hydroxyapatite as subepithelial plaques or tubular deposits in the renal papillae. We investigated the effect of renal epithelial exposure to hydroxyapatite crystals in vitro to develop an insight into the pathogenesis of kidney stones.

Materials And Methods: NRK52E cells (No.