Publications by authors named "Hassan K Salamatullah"

Objectives: Spontaneous intracerebral hemorrhage (ICH) poses high mortality and morbidity rates with limited evidence-based therapeutic approaches. We aimed to evaluate the current evidence for the role of minimally invasive surgery (MIS) in the management of ICH.

Methods: This systematic review and meta-analysis followed recommended guidelines and protocols.

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Article Synopsis
  • Endovascular thrombectomy (EVT) combined with medical treatment (MT) significantly improves disability and functional outcomes in patients with large-vessel occlusions compared to MT alone, based on a systematic review of 15 randomized clinical trials involving 3897 patients.
  • The study found higher rates of functional independence, excellent outcomes, and recanalization with the EVT plus MT approach, while safety outcomes were generally comparable, except for a higher risk of certain types of hemorrhage with EVT.
  • The findings suggest that EVT plus MT should be considered the standard care for acute ischemic stroke patients with large-vessel occlusions, although careful patient selection is crucial due to safety concerns.
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Background: Exercise in patients with multiple sclerosis (pwMS) found to improve symptom management and regain function. Whether exercise lowers neurofilament light chain (NfL), neuroaxonal injury biomarker, in MS remains unknown with conflicting findings. In this study, we aimed to assess the interaction between exercise and NfL levels in pwMS.

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Background: Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune disorder characterized by relapses of inflammation and demyelination primarily affecting the optic nerve and the spinal cord. C5 complement inhibition is an effective therapeutic approach in the treatment of NMOSD. In this systematic review and meta-analysis, we aimed to determine the role of C5 inhibitors in the treatment of patients with seropositive anti-aquaporin-4 antibody (AQP4+IgG) NMOSD.

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Background: Minor ischemic stroke, defined as National Institute of Health Stroke Scale score of 0-5 on admission, represents half of all acute ischemic strokes. The role of intravenous alteplase (IVA) among patients with minor stroke is inconclusive; therefore, we evaluated clinical outcomes of these patients treated with or without IVA.

Materials And Methods: We searched Medline, Embase, Scopus, and the Cochrane library until August 1, 2023.

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Background: Stroke is a significant global cause of mortality and long-term disability, potentially influenced by infections that heighten systemic inflammation and thrombotic events. The full impact of influenza vaccination on stroke remains uncertain. This systematic review and meta-analysis aimed to investigate the association between influenza immunization and stroke incidence.

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Background: Alteplase is the standard medical therapy for acute ischemic stroke (AIS) patients who present within 4.5 h of symptom onset. Tenecteplase is a modified alteplase variant with pharmacological and practical advantages over alteplase.

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Objectives This study aimed to evaluate the recurrence symptoms rate after anterior cervical discectomy and fusion (ACDF) for one year and seek the common cervical vertebral disk affected in a tertiary center in Saudi Arabia over the past five years. Methods This is a single-center, cross-sectional study conducted on patients followed in our center from January 2016 to December 2022. All patients who were older than 18 and underwent ACDF were included.

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Introduction: The World Health Organization defined electronic health as "the unified usage of information technology and electronic communications in the health sector." In the Kingdom of Saudi Arabia, outpatient encounters were largely shifted to virtual clinics due to the crisis caused by COVID-19. This study aimed to evaluate the neurology consultants', specialists', and residents' experience and perception of utilizing virtual services for neurological assessment in Saudi Arabia.

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Background: Diabetes mellitus is one of the most common diseases worldwide with significant morbidity and mortality. HbA1c remains one of the most important methods for diagnosis and monitoring of the disease. Since HbA1c is a reflection of the glucose attached to red blood cells, factors affecting hemoglobin and red blood cells' half-life can influence HbA1c measurements.

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Background: Obesity and its complications are associated with several adverse effects that may cause a serious impact on health. Antipsychotics-induced weight gain (AIWG) is one of the major, yet often neglected side effects of first and second generations antipsychotics. Importantly, several researches have shown metformin to be effective in managing weight gain especially, with AIWG.

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