Publications by authors named "Hassan Ghaffar"
Background: Hepatitis C virus (HCV) is a worldwide' health problem as Egypt has a very high prevalence (14.7%) that may affect the B-Lymphocytes, and in some cases leading to an expansion of monoclonal B-cell detected by immunoglobulin heavy chain (IgH) gene rearrangement. Therefore, we aimed to assess the occurrence of IgH gene rearrangement in Egyptian chronic HCV patients and studying the effect of oral direct-acting antiviral (DAAs) therapy on regression of the clonality markers.
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- Most current larynx cancer treatments tend to overlook cancer stem cells (CSCs), which are key drivers of tumor growth and resistance to therapies.
- Two herbal compounds, Epigallocatechin-3-gallate (EGCG) from green tea and Honokiol (HNK), were studied for their potential anti-tumor effects on laryngeal CSCs and regular cancer cells in the HEp-2 cell line.
- EGCG showed strong ability to induce apoptosis specifically in CSCs, while HNK was more effective in killing regular cancer cells and affected different signaling pathways involved in cell survival and death.
Background: Genetic mutations have been proven to be one of the major criteria in the diagnosis and distinction of different myeloproliferative neoplasm (MPN) subtypes. Therefore, the aim of this study was to determine the molecular profile of Egyptian patients with MPN subtypes and correlate with clinicopathological status.
Methods: A series of 200 patients with MPNs (92 polycythemia vera, 68 essential thrombocythemia, and 40 primary myelofibrosis) were included in this study.
Article Synopsis
- Immunotactoid glomerulopathy (ITG) is a rare kidney condition linked to blood disorders, where treatment of underlying malignancies can reverse kidney issues.
- A 55-year-old woman with diabetes and ITG initially showed no signs of lymphoma, but two years later she was diagnosed with diffuse large B-cell lymphoma.
- After chemotherapy and radiation, she achieved complete remission of both lymphoma and ITG, highlighting the importance of monitoring patients with ITG for potential blood cancers.
Article Synopsis
- The study investigates the effects of different sources of mesenchymal stem cells (MSCs) on kidney regeneration after acute kidney injury (AKI) induced by cisplatin in rats.
- 120 Sprague-Dawley rats were injected with cisplatin and then treated with rat bone marrow stem cells (rBMSCs), human adipose tissue-derived stem cells (hADSCs), or human amniotic fluid-derived stem cells (hAFSCs) to evaluate their renal recovery effects.
- Results indicated that MSCs from all sources helped improve renal function and tissue damage, with rBMSCs showing the best outcomes in terms of serum creatinine levels and early renal tissue proliferation, while hAFSCs
Background And Objectives: Cisplatin is a nephrotoxic chemotherapeutic agent. So, preventive measures worth to be evaluated. Human amniotic fluid stem cells (hAFSCs) in prevention or amelioration of cisplatin-induced acute kidney injury (AKI) in Sprague-Dawley rates have been tested.
View Article and Find Full Text PDFBackground/aims: Long-term evaluation of cisplatin induced nephrotoxicity and the probable renal protective activities of stem cells are lacking up until now. We evaluated the early and long-term role of human adipose derived mesenchymal stem cells (ADMSCs) in prevention or amelioration of cisplatin induced acute kidney injury (AKI) in Sprague-Dawley rats. For this, we determined the kidney tissue level of oxidative stress markers in conjugation with a renal histopathological scoring system of both acute and chronic renal changes.
View Article and Find Full Text PDFAcute kidney injury (AKI) is a complex clinical condition associated with significant morbidity and mortality and lacking effective management. Ischemia-reperfusion injury (IRI) remains one of the leading causes of AKI in native and transplanted kidneys. The aim of this study was to evaluate the efficacy of adipose-derived mesenchymal stem cells (ADSCs) in the prevention of renal IRI in rats.
View Article and Find Full Text PDFBackground: Tuberculosis is a growing international health concern. It is the biggest killer among the infectious diseases in the world today. Early detection of drug resistance allows starting of an appropriate treatment.
View Article and Find Full Text PDFPurpose: About one-third of sporadic lung adenocarcinomas demonstrates biallelic inactivation of the LKB1 gene, but the timing of this event is not known.
Design: We performed LKB1 immunohistochemistry on 35 primary lung adenocarcinomas and 96 atypical adenomatous hyperplasias (AAH), a form of early glandular neoplasia from which some lung adenocarcinomas arise.
Results: In all cases, strong cytoplasmic staining was noted in the non-neoplastic epithelium lining the airways from the bronchi to the terminal bronchioles.