Optic neuritis: A South African hospital-based prospective study protocol.

Background: Optic neuritis is a relatively common disease with an estimated lifetime risk of 0.6 per 1000; the estimated prevalence is 1-5 per 100 000/year. It occurs because of inflammation of the optic nerve from a variety of causes.

Response to botulinum neurotoxin injections in large-angle infantile esotropia: a post hoc analysis.

Purpose: To determine the anticipated reduction of baseline angle of esotropia and identify predictors of change following botulinum neurotoxin (BNT) injections in large-angle infantile esotropia.

Methods: This was a prospective, longitudinal study of children <10 years of age diagnosed with infantile esotropia of >30 and given either 1, 2, or 3 BNT injections. Post-injection change from baseline deviation was recorded, and predictors of reduction were analyzed.

Prevalence of complications in eyes with nanophthalmos or microphthalmos: protocol for a systematic review and meta-analysis.

Introduction: Microphthalmos and nanophthalmos are uncommon ocular conditions, whereby affected eyes have smaller dimensions compared to the normal population. Microphthalmos and nanophthalmos present several challenges to ophthalmologists; they have spontaneous and post-operative sequelae such as high hyperopia, angle-closure glaucoma, uveal effusion syndrome, and retinal detachment. This systematic review and meta-analysis intends to assess the prevalence of both the spontaneous complications associated with nanophthalmos and microphthalmos, as well as the post-surgical complications associated with nanophthalmos or microphthalmos.

Treatment Outcome of Tubercular Uveitis in a High TB and HIV Setting: A Prospective Cohort Study.

Purpose: To determine the time to resolution of inflammation in tubercular uveitis (TBU) cases on standard anti-tubercular treatment. Sub-analysis of time to resolution according to HIV status was also performed.

Patients And Methods: A prospective cohort study of presumed idiopathic uveitis cases >18 years underwent the tuberculin skin test, QuantiFERON-TB Gold test, and ocular tuberculosis (TB) polymerase chain reaction test.

Cost comparison between botulinum neurotoxin and surgery in the treatment of infantile esotropia in a tertiary public hospital.

Objective: To compare the cost implications of botulinum neurotoxin (BNT) injection to surgery in infantile esotropia (IE) in a public/government funded hospital.

Methods And Analysis: A simple costing comparison was undertaken for a randomised clinical trial in IE. Patients were randomised to receive either BNT or standard surgery.

Retinal nerve fibre layer thickness in a normal black South African population.

Background: The measurement of retinal nerve fibre layer (RNFL) thickness on spectral domain OCT (SD-OCT) are compared with built-in age- and gender-matched European normative databases and this difference is used to assist with glaucoma diagnosis. However, there are differences in RNFL thickness between population groups. Therefore, using the built in European normative database as a comparison across all population groups could lead to erroneous results, due to the basic assumption that the normative values for non-European populations are the same as their European counterparts.