Publications by authors named "Hassan Abd-ElGhaffar"
The power of tumorigenesis, chemo-resistance and metastasis in malignant ovarian tumors resides in a tiny population of cancer cells known as ovarian cancer stem cells (OCSCs). Developing nano-therapeutic targeting of OCSCs is considered a great challenge. The potential use of poly(lactic-co-glycolic acid) nanoparticles (PLGA NPs) was investigated as a drug delivery system for paclitaxel (PTX) against OCSCs in vitro and in vivo.
View Article and Find Full Text PDFBackground: Tuberculosis is a growing international health concern. It is the biggest killer among the infectious diseases in the world today. Early detection of drug resistance allows starting of an appropriate treatment.
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- There is ongoing debate about the effectiveness of clonal diagnosis methods for lymphoproliferative disorders, leading researchers to investigate gene scanning as a potential solution.
- In a study involving various patient groups (including ALL, NHL, and CLL), gene scanning successfully identified monoclonality in a significant percentage of cases, demonstrating its potential as an effective diagnostic tool.
- The findings indicated that gene scanning has a high sensitivity and positive predictive value, making it a promising method for detecting malignant clones in lymphoproliferative disorders.