Publications by authors named "Hasni Kannangara"
Article Synopsis
- The sympathetic nervous system (SNS) plays a significant role in regulating bone metabolism, with abundant SNS innervation found in the periosteum and bone marrow, consisting of specific nerve fibers.
- Using a viral tracing method, researchers have identified 87 specific brain nuclei that send SNS signals to bone, revealing the complexity of this neural connection.
- Certain brain areas, like the raphe magnus and periaqueductal gray, show higher levels of SNS activity, emphasizing the importance of these sites in understanding bone metabolism and pain regulation.
Article Synopsis
- The sympathetic nervous system (SNS) plays a significant role in bone metabolism, with nerves found in the periosteum and bone marrow showing evidence of noradrenergic fibers.
- Recent research using pseudorabies (PRV) tracing has identified 87 brain nuclei that send efferent SNS signals to bone, highlighting the complexity of this communication.
- Specific regions, like the raphe magnus and periaqueductal gray, exhibit varying levels of SNS activity, leading to new insights into how these neural pathways could be linked to bone health and pain management.
Mol Psychiatry
August 2023
Article Synopsis
- Clinical studies suggest that luteinizing hormone (LH), typically known for its role in fertility, may also influence cognitive decline and mood disorders in aging, particularly in post-menopausal women.
- The study utilized various behavioral tests on 12-month-old mice lacking LH signaling to explore its impact on cognitive and emotional behaviors, revealing that these mice did not show the anxiety seen in wild type mice.
- The findings indicate that loss of LH signaling can reverse certain age-related emotional issues, potentially paving the way for future treatments targeting LH activity.
Ann N Y Acad Sci
July 2023
Article Synopsis
- Seasonal changes in food intake and body fat in animals are influenced by changes in light duration, regulated by melatonin from the pineal gland.
- The mediobasal hypothalamus plays a key role in integrating these seasonal variations through the detection of the thyroid-stimulating hormone (TSH).
- Tanycytes in the hypothalamus are involved in regulating energy balance and modulating the blood-hypothalamus barrier, with TSH having potential effects beyond traditional single-target actions.
Article Synopsis
- Recent research highlights follicle-stimulating hormone (FSH) as a target for treating diseases like osteoporosis, obesity, and Alzheimer's, with findings showing that blocking FSH can prevent various health issues in mice.
- The development of a humanized FSH-blocking antibody called MS-Hu6 has shown promise in preventing osteoporosis in mice and has safe initial testing in monkeys, demonstrating effective localization to bone and bone marrow.
- MS-Hu6 has been optimized for stability and safety, showing no immunogenic responses in human cell cultures, making it ready for potential future human clinical trials.
Article Synopsis
- There’s growing evidence that anterior pituitary hormones affect various body tissues beyond their usual single-target roles, influencing bone, fat, liver, and even brain functions.
- The study created a detailed neuroanatomical atlas showcasing the expression of three receptors (TSHR, LHCGR, FSHR) across numerous brain regions using advanced RNA detection technologies.
- This research reveals high expression of these receptors in key brain areas, potentially linking hormone receptor activity to somatic functions and opening pathways for understanding human diseases, including Alzheimer’s.
