Publications by authors named "Hashini Ekanayake Mudiyanselage"
J Am Chem Soc
November 2024
Article Synopsis
- In sperm cells, protamine replaces histones to compact DNA significantly more than in other cells, resulting in extreme DNA condensing.
- Using confocal microscopy and optical tweezers, researchers found that increasing protamine levels led to greater compaction of λ-DNA, forming resistant tangles and reducing its length by up to 40%.
- The study suggests that protamine interacts with DNA bases through hydrogen bonds, impacting both local and overall chromatin organization, which may contribute to transcriptional silencing in sperm.
