Publications by authors named "Hashimoto Tatsuya"

Background: () gene mutations are a type of driver mutation discovered in the 1980s, but for a long time no molecular targeted drugs were available for them. Recently, sotorasib was developed as a molecular targeted drug for mutations. It is therefore necessary to identify the characteristics of patients with mutations.

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Background: Chemotherapy-induced peripheral neuropathy (CIPN) has a significant impact on the therapeutic efficacy of chemotherapy and patients' quality of life. The aim of this study was to assess the preventive effect of lafutidine on CIPN.

Methods: Patients were randomly assigned (1:1) to carboplatin and paclitaxel chemotherapy with lafutidine 10 mg twice daily (lafutidine group) or without lafutidine (control group).

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Purpose: Remifentanil is one of the most commonly used opioids intraoperatively. Previous reports indicate that long-term use of opioids may lead to cross-tolerance to remifentanil, which poses a challenge in the control of acute pain intraoperatively. However, there is limited information regarding cross-tolerance to remifentanil, especially in visceral pain.

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The opioid analgesic hydromorphone has a low renal excretion ratio; however, exposure after oral administration is several times higher in those with moderate or severe renal impairment. We evaluated the impact of renal impairment on the steady-state pharmacokinetics of intravenously administered hydromorphone in patients with cancer being treated for pain. This was an open-label, prospective, parallel-comparison, interventional clinical pharmacology study.

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Purpose: As the cancer survivors increase, patients using long-term and high-dose opioids are also increasing. Therefore, the promotion of appropriate use is important. This study investigated the actual status of opioid prescriptions in Japan and identified factors associated with long-term, high-dose prescription.

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Introduction: Reduced port laparoscopic surgery using an umbilical zigzag incision is comparable to conventional multiport laparoscopic surgery. This method is associated with improved cosmesis and decreased wound pain.

Presentation Of Case: A 67-year-old man visited our hospital.

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Introduction: Liver metastasis has not been sufficiently evaluated in lung cancer so far. We retrospectively analyzed the distant metastasis of Non-squamous non-small cell lung cancer (NSQ-NSCLC), including liver metastasis, and association between prognosis and therapeutic effect of bevacizumab treatment.

Patients And Methods: Clinical data were collected from 1954 patients with lung cancer admitted in our hospital between 1st April 2011 and 31 March 2019.

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Background: Vertebral artery dissection (VAD) sometimes has no specific symptoms and is difficult to differentiate from other forms of headache.

Case Presentation: A woman in her thirties had a severe, throbbing left-sided headache. A migraine without aura was suspected and zolmitriptan was administered, which alleviated the symptoms.

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Background: Chronic abdominal pain is a common clinical problem. However, diagnosing chronic abdominal pain often requires detailed diagnostic evaluations in addition to sufficient history taking and physical examination, owing to its uncertain etiology.

Case Presentation: We report a case of a 36-year-old man with chronic abdominal pain originating from postoperative adhesions.

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We numerically study the spatiotemporal dynamics and early detection of thermoacoustic combustion instability in a model rocket combustor using the theories of complex networks and synchronization. The turbulence network, which consists of nodes and vertexes in weighted networks between vortices, can characterize the complex spatiotemporal structure of a flow field during thermoacoustic combustion instability. The transfer entropy allows us to identify the driving region of thermoacoustic combustion instability.

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Purpose: The Geriatric Nutritional Risk Index (GNRI) is a new index recently introduced to predict the risk of nutrition-related complications and mortality. Our aim is to examine the association between the GNRI and long-term prognosis in patients with esophageal squamous cell carcinoma (ESCC) who underwent esophagectomy.

Methods: The present study enrolled consecutive 216 patients with ESCC who underwent esophagectomy.

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Background: Sympathetic block in the upper limb has diagnostic, therapeutic and prognostic utility for disorders in the upper extremity that are associated with sympathetic disturbances. Increased skin temperature and decreased sweating are used to identify the adequacy of sympathetic block in the upper limb after stellate ganglion block (SGB). Baroreflexes elicited by postural change induce a reduction in peripheral blood flow by causing sympathetic vasoconstriction.

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Background/aims: Anastomotic leakage (AL) after esophagectomy is associated with high rates of postoperative morbidity and mortality. In cases with leakage, a refractory fistula (RF) is sometimes recognized after esophagectomy. The aim of this study was to evaluate the risk factors for RF after esophagectomy with gastric tube reconstruction.

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Article Synopsis
  • A 67-year-old man with a history of salivary duct carcinoma developed symptoms suggesting gastric cancer one year after surgery for his initial diagnosis.
  • Diagnostic imaging revealed abnormal areas in multiple lymph nodes and the stomach, leading to a gastroduodenoscopy that showed a large, bleeding ulcer mimicking primary gastric cancer.
  • Despite efforts to diagnose and treat, histological examination ultimately confirmed that the gastric lesion was a metastasis of the original salivary duct carcinoma, indicating the challenges in distinguishing between primary and metastatic cancer.
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  • An 82-year-old Japanese man was admitted to the hospital for constipation and abdominal pain, where imaging showed both a large fecal buildup and free air in his abdomen.
  • The patient underwent emergency surgery for suspected gastrointestinal perforation, but no actual perforation or damage was found in the digestive tract.
  • The case suggests that the free air was likely caused by a mucosal injury due to pressure from the accumulated feces, and the patient recovered well post-surgery, being discharged after 13 days.
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  • - The study aimed to see if an intensive preoperative respiratory rehabilitation (PR) program could prevent pulmonary complications after esophagectomy in esophageal cancer patients.
  • - It involved 60 patients, with one group undergoing rehabilitation for over a week and the other group not receiving any prior rehab.
  • - Results showed significantly lower complications in the PR group, indicating that preoperative rehabilitation can effectively reduce risk factors for postoperative issues.
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  • * He underwent thoracoscopic enucleation of the tumor, initially suspected to be an esophageal leiomyoma, and the diagnosis was confirmed post-surgery.
  • * The patient recovered well without complications and was discharged on the 12th day, suggesting that the prone position may be a better positioning option for this type of surgery than the left lateral position.
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Opioids are not generally deemed to have an analgesic ceiling effect on cancer pain. However, there have been occasional reports of tolerance to opioid development induced by multiple doses of fentanyl. The authors report a case of suspected tolerance to the analgesic effect of opioid, in which an increasing dose of fentanyl failed to relieve the patient's cancer pain symptoms, but opioid switching to oxycodone injections enabled a dose reduction to below the equivalent dose conversion ratio.

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Article Synopsis
  • The Geriatric Nutritional Risk Index (GNRI) is a new tool designed to evaluate the nutritional status and predict complications in elderly patients, but its efficacy in gastrointestinal cancer patients has not been well-studied.
  • In a study of 122 esophageal cancer patients who underwent surgery, researchers compared outcomes based on GNRI scores, categorizing patients into high (≥90) and low (<90) risk groups.
  • Findings revealed that the low GNRI group faced significantly higher rates of respiratory complications, establishing GNRI as a valuable marker for predicting postoperative risks in this patient population.*
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  • * She received neoadjuvant chemotherapy (TS-1 combined with CDDP) which helped reduce the tumor size and improve her serum protein levels ahead of surgery.
  • * Following chemotherapy, she successfully underwent a total gastrectomy and additional procedures, highlighting the potential effectiveness of neoadjuvant treatment for such patients.
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  • Gastric stump carcinoma, first identified in 1922, has been extensively studied, focusing on its epidemiology, causes, and characteristics, particularly in relation to infections such as H. pylori and Epstein-Barr virus.* -
  • Research indicates that there is no significant difference in prognosis between gastric stump carcinoma and primary gastric cancer located in the upper third of the stomach.* -
  • Recent advances, such as endoscopic submucosal dissection, are being used for early-stage treatment of gastric stump carcinoma, although many aspects, especially regarding molecular biology and H. pylori's role in its development, still need further investigation.*
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  • The study aimed to evaluate the effectiveness of the high-sensitivity Glasgow prognostic score (HS-GPS) after surgery in gastric cancer patients and to identify factors influencing score improvement.
  • In a retrospective analysis of 236 gastric cancer patients, researchers found that changes in HS-GPS from before to after surgery correlated with patient outcomes and prognostic factors.
  • The results indicated that HS-GPS after surgery is a significant independent predictor of prognosis, suggesting that patients with no score improvement may need additional treatments like adjuvant chemotherapy.
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Human epidermal growth factor receptor 2 (HER2) status has been evaluated at the primary site of gastric cancer when planning trastuzumab therapy against recurrent or metastatic lesions, since tissue sampling is uncommon in recurrent or metastatic lesions. This study retrospectively investigated the concordance of HER2 expression between primary and metastatic/recurrent lesions in order to confirm sensitivity to trastuzumab. The subjects comprised 37 patients with gastric adenocarcinoma who underwent tissue biopsy or surgical resection of the primary sites and 49 paired synchronous or metachronous metastatic sites (excluding lymph nodes) at the Fukuoka University Hospital between January, 1998 and September, 2012.

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Article Synopsis
  • The study aimed to assess how effective the high-sensitivity modified Glasgow prognostic score (HS-mGPS) is at predicting outcomes for gastric cancer patients before they undergo surgery.
  • Involving 552 patients, the study found that both the HS-mGPS and the traditional mGPS were strong predictors of prognosis, with HS-mGPS showing a particular advantage in identifying risk for patients with stage I and IV gastric cancer.
  • The findings suggest that using HS-mGPS provides better prognostic information compared to the standard mGPS in surgical candidates with gastric cancer.
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